Clinical trials: Epiretinal Membranes
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cataract Senile, Macula Hole
Ocular Coherence Tomography During Cataract Assessment
Many patients will have underlying maculopathy present when undergoing cataract surgery, which are not visible on fundoscopy alone.
- Conditions
- Cataract Senile, Macula Hole, Epiretinal Membrane, Age Related Macular Degeneration
- Trial name
- NCT05287269
- Testing
- Ocular Coherence Tomography
- Where
- United Kingdom
- Volunteers
- 626 people, healthy volunteers welcome
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Epiretinal Membrane
Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal
The purpose of this study is to evaluate the changes in visual acuity, metamorphopsia, and thickness of retinal layers after epiretinal membrane removal and to investigate factors associated with visual function.
- Trial name
- NCT01474655
- Testing
- Pars plana vitrectomy and removal of epiretinal membrane
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Macular Holes, Intraocular Lens Opacification
Oral Sedation in Vitreoretinal Surgery
The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.
- Conditions
- Macular Holes, Intraocular Lens Opacification, Vitrectomy, Vitreous Hemorrhage
- Trial name
- NCT04346095
- Testing
- Oral Sedatives with or Without Analgesia, Intravenous Sedatives with or Without Analgesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rocky Vista University, LLC
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.
Ophthalmopathy
Single Superior ILM/ERM Flap for the FTMH.
In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.
- Trial name
- NCT05494242
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Omer Othman Abdullah
Macular Edema, Epiretinal Membrane
Intravitreal Dexamethasone Implant for Persistent Macular Thickening and Edema After Vitrectomy for Epiretinal Membrane
This study seeks to evaluate the effect of the intravitreal 0.7mg dexamethasone implant on central macular thickness and visual acuity in those patients with persistent macular edema after pars plana vitrectomy for epiretinal…
- Conditions
- Macular Edema, Epiretinal Membrane, Vitrectomy
- Trial name
- DEMO (NCT02995746)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Macular Pucker
Compare ELP in Patients With Elective Phaco-VTX Surgery in One Eye and a Single Lens Phaco Surgery on the Other Eye
The aim of the study is to gain more insight into the potential impact of a vitrectomy (removal of the vitreous) on postoperative effective position of the intraocular lens (IOL).
- Trial name
- ELP (NCT04397068)
- Testing
- phaco-vitrectomy
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epiretinal Membrane, Dry Age Related Macular Degeneration
(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000
This study will measure how well PathFinder 1.0 detects retinal abnormalities on macular cube OCT B-scans by assessing its sensitivity and specificity.
- Conditions
- Epiretinal Membrane, Dry Age Related Macular Degeneration, Macular Abnormalities, Retina Disease
- Trial name
- NCT07680244
- Testing
- PathFinder 1.0 on CIRRUS HD-OCT
- Where
- 6 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec-Dublin CoCe
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diabetic Maculopathy, Age Related Macular Degeneration
Reading Analysis in Ophthalmologic Patients
Investigation of the reading parameters and fixation behavior in patients with different ocular diseases (age-related macular degeneration, glaucoma, diabetic maculopathy, epiretinal membrane) and healthy subjects.
- Conditions
- Diabetic Maculopathy, Age Related Macular Degeneration, Glaucoma, Epiretinal Membrane
- Trial name
- NCT03750149
- Testing
- EyeTracker
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Epiretinal Membrane, Vitreomacular Traction
Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel
Epiretinal membranes (ERM) are cellular membranes on the surface of the retina that result in distortion of the vision (metamorphopsia), and decreased best-corrected visual acuity.
- Trial name
- NCT00892619
- Testing
- using ILM forceps alone, Breaking and peeling with end-grasping forceps
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Retinal Detachment, Macular Pucker
Zeiss RESIGHT Disposable Lenses Evaluation Study
To evaluate the intra-operative efficacy of a new intra-operative viewing device.
- Conditions
- Retinal Detachment, Macular Pucker, Macular Holes, Vitreomacular Traction
- Trial name
- RESIGHT (NCT05860985)
- Testing
- ZEISS disposable
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epiretinal Membrane
Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Epiretinal Membrane
Purpose: To evaluate macular sensitivity and its correlation with visual acuity and Spectral Domain Optical Coherence Tomography (SD-OCT) in eyes with idiopathic epiretinal membrane (ERM).
- Trial name
- NCT01481987
- Testing
- Epiretinal Membrane Surgical treatment
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Epiretinal Membrane, Macular Holes
Comparative Study of Sharkskin Versus Grieshaber Forceps During ILM Peeling
The purpose of this study is to compare the performance and anatomic outcomes of the Sharkskin internal limiting membrane (ILM) forceps and the Grieshaber ILM forceps in macular surgery.
- Trial name
- NCT04459949
- Testing
- Sharkskin, Grieshaber
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Glaucoma, Macular Pucker
Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) Study
Since the introduction of vitrectomy in 1971, this procedure has become the third most frequently performed ophthalmic surgery. Approximately 225,000 vitrectomies are performed annually in the United States and indications…
- Conditions
- Glaucoma, Macular Pucker, Macula Hole, Vitreomacular Traction
- Trial name
- PROVE (NCT01162356)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Epiretinal Membrane, Retinal Hemorrhage
Robotic Retinal Dissection Device Trial
The purpose of the study is to determine whether use of a robotic system improves the precision and therefore safety of high precision steps in retinal surgery.
- Trial name
- R2D2 (NCT03052881)
- Testing
- Robot assisted surgery
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Ocular Inflammation
PGE2 Levels in Patient Treated With NSAIDs
The aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (NSAIDs) and prostaglandinE2 (PGE2) in eyes scheduled for vitrectomy. All patients received the study drugs for 3 days before surgery.
- Trial name
- NCT03597867
- Testing
- Dicloftil, Nevanac, Indom
- Where
- Italy
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Epiretinal Membrane, Macular Edema
A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes
To determine if an intravitreal sustained release dexamethasone implant (Ozurdex®) injected at the conclusion of surgery in patients undergoing vitrectomy and membrane peeling for idiopathic epiretinal membranes is safe and…
- Trial name
- NCT01701518
- Testing
- Ozurdex
- Where
- 2 sites in Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre