Clinical trials: Epistaxis
Epistaxis
A Prospective Randomised Controlled Trial of Management of Recurrent Nosebleeds in Children
To determine whether the selective application of a combined treatment regimen of silver nitrate cautery and 4 weeks of Naseptin cream is superior to naseptin treatment alone in the management of recurrent paediatric epistaxis.
- Trial name
- NCT00390663
- Testing
- Nasal Cautery
- Where
- United Kingdom
- Volunteers
- 216 people
- Sponsor
- NHS Greater Glasgow Yorkhill Division
Hereditary Hemorrhagic Telangiectasia
Anti-Estrogen Therapy for Hereditary Hemorrhagic Telangiectasia A Double-Blind Placebo-Controlled Clinical Trial
Hereditary hemorrhagic telangiectasia (HHT) is associated with recurrent epistaxis in 90% of cases. Good response to hormone treatment has been documented, although its use remains controversial.
- Trial name
- NCT00375622
- Testing
- Tamoxifen
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations
Comprehensive HHT Outcomes Registry of the United States (CHORUS)
The Comprehensive HHT Outcomes Registry of the United States (CHORUS) is an observational registry of patients diagnosed with Hereditary Hemorrhagic Telangiectasia (HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations, Telangiectasia, Epistaxis
- Trial name
- CHORUS (NCT06259292)
- Where
- 16 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Cure HHT
Epistaxis
Hot Water Irrigation in Posterior Epistaxis
This study was aimed to assess the efficacy and factors affecting the success of hot water irrigation in management of posterior epistaxis.
- Trial name
- NCT04151888
- Testing
- Foley catheter
- Volunteers
- 20 people
- Sponsor
- Assiut University
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Treatment of Nasal Staphylococcus Aureus Colonization in Patients With HHT
Compare the frequency of epistaxis and quality of life related to nasal bleeding in patients with HHT colonized with sataphylococo before and after being treated with mupirocin ointment.
- Trial name
- NCT02963129
- Testing
- Mupirocin
- Where
- 2 sites in Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Epistaxis
Management of Persistent Epistaxis Using Floseal Hemostatic Matrix
Nosebleeds that persist even after adequate traditional nasal packing may require aggressive treatment strategies to stop bleeding.
- Trial name
- NCT02488135
- Testing
- Floseal Hemostatic Matrix, Traditional Nasal Packing
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Alberta
Oral Surgery
Epinephrine Nasal Drops for Epistaxis During Nasal Intubation
Epistaxis is the most common complication of nasotracheal intubation. Incidence of epistaxis during nasotracheal intubation ranges from 22% to 80%.
- Trial name
- NCT06789549
- Testing
- epinephrine nasal drops, oxymetazoline nasal drops
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Padjadjaran
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Pazopanib for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia
Investigators will test the value of very low dose Pazopanib administered to patients with hereditary hemorrhagic telangiectasia for the reduction in the severity of nose bleeds in those with frequent and long duration bleeding…
- Trial name
- NCT03850730
- Testing
- Pazopanib
- Volunteers
- 30 people
- Sponsor
- Cure HHT
Telangiectasia, Hereditary Hemorrhagic, Epistaxis
North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
The purpose of the NOSE Study is to carefully examine the efficacy and safety of 3 nasal sprays (bevacizumab, estriol, and tranexamic acid), compared to placebo, for the treatment of HHT related nosebleeds.
- Trial name
- NOSE (NCT01408030)
- Testing
- Sterile saline, Bevacizumab, Estriol
- Where
- 6 sites in United States
- Volunteers
- 123 people
- Sponsor
- James Gossage
Epistaxis, Analgesia
The Effect of Local Anesthesia With Lidocaine During Insertion and Removal of Nasal Packing
This study aims to investigate the effect of local nasal anesthesia with lidocaine spray on the insertion of nasal tampons during active nasal bleeding.
- Trial name
- NCT04519463
- Testing
- Xylocaine Mucosal Product
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muhamed Masalha
Epistaxis
Epistaxis in Patients Receiving Oral Anticoagulants and Antiplatelet: Prevalence Risk Factors at a Tertiary Care Hospital in Nepal
This study aims to determine the prevalence of epistaxis and identify the associated risk factors among patients receiving oral anticoagulants and antiplatelet at a tertiary care hospital in Nepal.
- Trial name
- Epistaxis (NCT06906861)
- Where
- Nepal
- Volunteers
- 284 people
- Sponsor
- Institute of medicine, Maharagjung medical campus
Epistaxis
Risk Factors of Epistaxis Recurrence in Adults
We study all patients admitted to the Emergency Department in the Institution between 01/2022 and 07/2023. The information about the recurrence of nose bleeding was searched on their medical file and by calling the patient to…
- Trial name
- FREA (NCT06657053)
- Where
- France
- Volunteers
- 145 people
- Sponsor
- University Hospital, Grenoble
HHT, Morbus Osler
Intranasal Submucosal Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
In a case series intranasal submucosal bevacizumab has been shown to reduce epistaxis in patients suffering from Hereditary Haemorrhagic Telangiectasia together with KTP Laser therapy.
- Conditions
- HHT, Morbus Osler, Epistaxis
- Trial name
- NCT01314274
- Testing
- Bevacizumab, NaCl
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University of Vienna
Epistaxis
Intranasal TXA for Anterior Epistaxis in the Emergency Department
The objective of this study is to evaluate the efficacy of and patient satisfaction with the use of intranasal tranexamic acid (TXA) for anterior nosebleeds in the emergency department (ED).
- Trial name
- NCT04054687
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Mercy Health Ohio
Epistaxis, Anterior Ethmoid Artery
Cauterization of the Anterior Ethmoidal Artery by Transconjunctival Approach
The incidence of epistaxis varies from 7 to 14% in the general population and represents 30 per 100,000 emergency room admissions in adults. Most nasal bleeding is self-limiting without the need for specific medical treatment.
- Trial name
- AEA (NCT05663099)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Telangiectasia, Hereditary Hemorrhagic, Osler Rendu Disease
Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO)
Timolol is a nonselective β-blocker commonly used in the treatment of glaucoma. Recently it has been used topically for the treatment of superficial hemangiomas.
- Trial name
- TEMPO (NCT02484716)
- Testing
- Timolol nasal spray
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Hospices Civils de Lyon
Nasopharyngeal Carcinoma Patients Treated With Curative Radiotherapy
Massive Nasal Bleeding in Patients With NPC Received Curative RT
To investigate the incidence, predictive markers, and survival impact of massive nasal bleeding in nasopharyngeal carcinoma (NPC) patients who received curative radiotherapy (RT) with/without chemotherapy.
- Trial name
- NCT06348485
- Testing
- Patients without massive nasal bleeding, Patients with massive nasal bleeding
- Where
- Taiwan
- Volunteers
- 1,327 people
- Sponsor
- Taichung Veterans General Hospital
Telangiectasia, Hereditary Hemorrhagic
Pomalidomide for the Treatment of Bleeding in HHT
This is a Phase II placebo-controlled double-blind study of pomalidomide in patients with hereditary hemorrhagic telangiectasia (HHT) with moderate to severe epistaxis who have anemia and/or require parenteral iron infusions or…
- Trial name
- PATH-HHT (NCT03910244)
- Testing
- Pomalidomide Oral Product
- Where
- 14 sites in United States
- Volunteers
- 145 people
- Sponsor
- The Cleveland Clinic
Epistaxis Nosebleed
Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management
In this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (Ankaferd®) on cessation of bleeding in epistaxis patients.
- Trial name
- NCT06490653
- Testing
- Blood Stopper (Ankaferd)
- Volunteers
- 186 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children
Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate
Von Willebrand disease (VWD) is the most common inherited bleeding disorder in children. It occurs due to a deficiency or dysfunction of von Willebrand factor, a protein that plays an essential role in blood clotting.
- Conditions
- Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children, Pediatric Hemostatic Disorders
- Trial name
- VWD-ASSIUT (NCT07410130)
- Testing
- Tranexamic Acid, Von Willebrand Factor-Containing Concentrates
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University