Clinical trials: Erosive Hand Osteoarthritis
Erosive Hand Osteoarthritis
Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis
Hand osteoarthritis is a common phenotype of osteoarthritis which affects about 70 % of the elderly population. Usually considered as a minor illness, it nevertheless leads to an important functional impairment.
- Trial name
- PASEO (NCT02370771)
- Testing
- Biological sampling, Radiographic evaluation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Rouen
Hand Osteoarthritis, Erosive Osteoarthritis
A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.
In response to the high prevalence of synovitis in hand osteoarthritis (OA) and its association with pain, there\'s a compelling rationale for investigating the efficacy of MTX in managing inflammatory erosive hand OA.
- Trial name
- MERINO:2 (NCT06281184)
- Testing
- Methotrexate, Treatment as usual
- Where
- Norway
- Volunteers
- 108 people
- Sponsor
- Diakonhjemmet Hospital
Polyarthritis
Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo
Interest of methotrexate in inflammatory rheumatisms was demonstrated since several years. At present time,there is no effective treatment against digital arthritis.
- Trial name
- ADEM (NCT01068405)
- Testing
- Methotrexate
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Erosive Hand Osteoarthritis
Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual Treatments
Randomized study comparing the structural efficacy of methotrexate versus placebo in digital osteoarthritis
- Trial name
- ADEM2 (NCT07501507)
- Testing
- Methotrexate Injectable Solution
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis
Open-label Safety Extension Study of Gevokizumab in Erosive Osteoarthritis of the Hand
The purpose of this study is to evaluate the long-term safety of gevokizumab in the treatment of active inflammatory, erosive osteoarthritis of the hand.
- Trial name
- NCT02293564
- Testing
- gevokizumab
- Where
- 28 sites in United States
- Volunteers
- 312 people
- Sponsor
- XOMA (US) LLC
Osteoarthritis
Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand
The purpose of this proof-of-concept study is to determine whether gevokizumab is effective in the treatment of inflammatory erosive osteoarthritis of the hand.
- Trial name
- NCT01882491
- Testing
- gevokizumab
- Where
- 23 sites in United States
- Volunteers
- 91 people
- Sponsor
- XOMA (US) LLC
Hand Osteoarthritis, Erosive Osteoarthritis
Methotrexate in Erosive Inflammatory Hand Osteoarthritis
A placebo-controlled randomized controlled trial exploring the effect of methotrexate on pain, function and structural outcomes in erosive inflammatory hand osteoarthritis.
- Trial name
- MERINO (NCT04579848)
- Testing
- Methotrexate Tablets, Folic Acid 1 MG
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- Diakonhjemmet Hospital
Erosive Osteoarthritis of the Hand
Efficacy Study of Apremilast (CC-10004) in Subjects With Erosive Hand Osteoarthritis
STUDY DESIGN: This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group, efficacy and safety study in 30 patients with erosive osteoarthritis of interphalangeal joints.
- Trial name
- NCT01200472
- Testing
- Apremilast
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hand Osteoarthritis
RANKL-blockade for the Treatment of Erosive Osteoarthritis (OA) of Interphalangeal Finger Joints
This is a randomized, double blind placebo controlled one-site proof-of-concept study in subjects with erosive osteoarthritis (OA) of interphalangeal (IP) finger joints.
- Trial name
- NCT02771860
- Testing
- denosumab, Calcium/Vit D supplementation
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Erosive Osteoarthritis of the Hand
Prescription-grade Crystalline Glucosamine Sulfate Therapy in Erosive Hand Osteoarthritis
The objective of this study is to evaluate the efficacy of prescription-grade Crystalline Glucosamine Sulfate (pCGS), as an add-on treatment to conventional therapy, compared to usual therapy alone, in patients with erosive…
- Trial name
- NCT05237596
- Testing
- Glucosamine Sulfate
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- University of Siena
Arthrosis of Hand
DIGItal Cohort Osteoarthritis Design
Introduction Osteoarthritis is a chronic disease characterized by a progressive degradation of articular cartilage. Hand OA involves symptomatically more than 1 million of subjects in France (i.e., painful or with functional…
- Trial name
- DIGICOD (NCT01831570)
- Testing
- GENETIC and radiographs
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Erosive Hand Osteoarthritis
A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis
This is a multicenter, randomized, double-blind, placebo-controlled study to compare the safety and efficacy of ABT-981 to placebo in subjects with erosive hand osteoarthritis.
- Trial name
- NCT02384538
- Testing
- ABT-981
- Volunteers
- 132 people
- Sponsor
- AbbVie
Erosive Osteo-Arthritis, Hand Osteoarthritis
Treatment of Erosive Digital Osteoarthritis by Transcutaneous Auricular Nerve Stimulation
Erosive hand osteoarthritis (EHOA) is a subtype of had osteoarthritis characterized by inflammation and pain, with subsequent burden.
- Trial name
- ADEPT (NCT03919279)
- Testing
- active tVNS
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Erosive Osteoarthritis, Psoriatic Arthritis
microRNA in Erosive Hand Osteoarthritis and Psoriatic Arthritis
Erosive osteoarthritis of the hand (EHOA) is a rare subset of HOA that affects mainly postmenopausal middle-aged women, featured by prominent signs of inflammation, severe progression, and typical radiographic changes of the…
- Trial name
- NCT05683769
- Testing
- miRNA
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Siena
Musculoskeletal Disease, Musculoskeletal Pain
Efficacy of Magnetotherapy in Hand Erosive Osteoarthritis.
Erosive arthritis (EA) is an unusual pathology. There is no definitive treatment and the conventional one has little efficacy. Despite using magnetotherapy (MGT) as a treatment, there is no evidence supporting its use.
- Conditions
- Musculoskeletal Disease, Musculoskeletal Pain, Physical Therapy
- Trial name
- NCT03805113
- Testing
- Magnetotherapy device
- Volunteers
- 19 people
- Sponsor
- Hospital Mutua de Terrassa
Osteoarthritis
Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand
The purpose of this proof-of-concept study is to determine whether gevokizumab is effective in the treatment of active inflammatory, erosive osteoarthritis of the hand.
- Trial name
- NCT01683396
- Testing
- gevokizumab
- Where
- 27 sites in United States
- Volunteers
- 87 people
- Sponsor
- XOMA (US) LLC
Osteoarthritis, Musculoskeletal Pain
Auricular Vagus Nerve Stimulation in Painful and Inflammatory Erosive Hand Osteoarthritis
Erosive hand osteoarthritis (EHOA) is a difficult-to-treat subtype of HOA characterized by local and systemic low-grade inflammation as well as by high level of pain and of disability.
- Conditions
- Osteoarthritis, Musculoskeletal Pain, Erosive Osteoarthritis
- Trial name
- ESTIVAL (NCT04520516)
- Testing
- Active VAGUSTIM device
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris