Clinical trials: Error, Refractive
Refractive Error
Comparative Study of Two Marketed Spherical Soft Contact Lenses
The purpose of this study is to obtain objective and subjective clinical data to compare the performance of two soft contact lenses.
- Trial name
- NCT01582789
- Testing
- enfilcon A, senofilcon A
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Refractive Errors
Air Optix Daily Wear Contact Lenses
The purpose of this Post-Market Clinical Follow-Up (PMCF) study is to assess long term performance and safety of Air Optix Aqua, Air Optix plus HydraGlyde Sphere, and Air Optix plus HydraGlyde Toric soft contact lenses in a…
- Trial name
- NCT05827224
- Testing
- Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive
- Where
- 5 sites in United States
- Volunteers
- 312 people
- Sponsor
- Alcon Research
Myopia, Myopia, Progressive
Myopia Progression With a Novel Extended Depth of Focus Contact Lens
Myopia has been increasing in prevalence and severity throughout the world over the last 30 years. Increasing levels of myopia are associated with increased frequencies and severity of various ocular pathologies, including…
- Trial name
- NCT03358862
- Testing
- NaturalVue Multifocal Contact Lens
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aller, Thomas A., OD
Astigmatism
Neural Mechanisms Underlying Astigmatism
This study is to compare the contrast sensitivity function and neural response to gratings before and after the orientation discrimination task in the astigmatism or amblyopia patients.
- Trial name
- NCT03735602
- Testing
- perceptual training
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia, Astigmatism
Early Changes Among FLEx, LASIK and FS-LASIK
To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx), laser in situ keratomileusis (LASIK) and femtosecond laser-assisted laser in situ keratomileusis…
- Trial name
- NCT02551796
- Testing
- lenticule extraction, laser in situ keratomileusis, FS assisted laser in situ keratomileusis
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Progressive Myopia, Pediatric Myopia
Efficacy of Different Interventions for Progressive Myopia After Orthokeratology Lens Wear
Myopia has emerged as a significant concern impacting the visual health of children and adolescents on a global scale. According to research conducted by Holden BA et al., it is projected that by the year 2050, the worldwide…
- Conditions
- Progressive Myopia, Pediatric Myopia, Orthokeratology-related Myopia Progression
- Trial name
- NCT07494799
- Testing
- OK Lens Continuation Group, OK Lens + 0.01% Atropine Group, OK Lens with Reduced Optical Zone Group
- Volunteers
- 3,890 people
- Sponsor
- Tianjin Medical University Eye Hospital
Corneal Wavefront Aberration
Higher Order Aberration and Relationship With Soft Contact Lens Modulus
Higher order aberrations are imperfects in the eye that affect the quality of image projected onto the retina. Soft contact lenses are made of different materials with different stiffness.
- Trial name
- NCT06425432
- Testing
- OVITZ xwave aberrometer
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Southern College of Optometry
Myopia
Effectiveness of Orthokeratology in Myopia Control
The high prevalence of myopia - especially in Asian countries - is well documented, as are the sight-threatening complications of high or degenerative myopia.
- Trial name
- NCT03465748
- Testing
- OrthoK
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Illinois College of Optometry
Myopia
Comparison of Myopic Small Incision Lenticule Extraction (SMILE) With VISUMAX 500 Versus VISUMAX 800 Platforms
Small incision lenticule extraction (SMILE) procedure is a well-known procedure for the correction of myopia. The purpose of this research study is to compare the two SMILE procedures with different laser platforms (VISUMAX 500…
- Trial name
- NCT07505264
- Testing
- SMILE surgery with Visumax 500, SMILE surgery with Visumax 800
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Singapore Eye Research Institute
Presbyopia
Evaluation of Safety and Efficacy of Intrastromal Implantation of CorVision® Bioengineered Corneal Inlay for Correction of Presbyopia.
This clinical investigation is a prospective, multicentre, non-comparative case series to assess safety and efficacy of CorVision® bioengineered corneal inlay for improving uncorrected near vision in presbyopic subjects.
- Trial name
- CorVision (NCT04465409)
- Testing
- Intrastromal implantation of CorVision bioengineered corneal inlay for correction of presbyopia.
- Where
- Czechia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- LinkoCare Life Sciences AB
Myopia
Efficacy of a Novel Myopia Defocus Spectacle Lens in School-Aged Children
This study aims to evaluate the short-term efficacy and safety of a novel, proprietary spectacle lens. Forty myopic participants, aged 6 to 15 years, will be prescribed with the study spectacles for a period of six months.
- Trial name
- BLMC (NCT07511387)
- Testing
- BCMC lens
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Refractive Error
Proof of Concept Study for First-Sight Refractive Error Correction: Direct Comparison to Manifest Refraction and Autorefraction Results
Proof of concept study is to compare the best corrected visual acuity obtained via First-Sight lenses with the clinical "gold standard" of manifest refraction and autorefraction.
- Trial name
- NCT01342393
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Myopia
Clinical Evaluation on Using Personal Face Masks With Spectacles Versus Contact Lenses
The aim of this study was to explore satisfaction with vision correction and ease of use of PFM (Personal Face Masks) in a group of spectacle wearers who were randomised to continue wearing spectacles or be fitted with daily…
- Trial name
- NCT04658797
- Testing
- somofilcon A Daily Disposable Contact Lens, Single Vision Spectacle for Vision Correction, Personal Facemask
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Presbyopia
PROductivity Study of Presbyopia Elimination in Rural-dwellers III
The investigators will conduct an embedded mixed methods study in which the primary approach is a randomized controlled trial (RCT), and the secondary or embedded approach is a descriptive qualitative study.
- Trial name
- PROSPERIII (NCT04654013)
- Testing
- Spectacles
- Where
- India
- Volunteers
- 1,291 people
- Sponsor
- Queen's University, Belfast
Presbyopia
The VEPRO Trial: A Cross-Over Randomised Controlled Trial Comparing 2 Corrective Lenses for Patients With Presbyopia
The VEPRO trial is a cross-over randomised controlled trial comparing 2 corrective lenses for patients with presbyopia. The aim of the study is to compare the effectiveness of two corrective lenses: an old generation (Varilux…
- Trial name
- VEPRO (NCT00635115)
- Testing
- a new generation of corrective lens for presbyopia (i.e., Varilux Panamic Orma Crizal), an old generation of corrective lens for presbyopia (i.e., Varilux Comfort Orma Crizal)
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Santéclair
Astigmatism, Myopia
Comparative Clinical Evaluation of Soft Toric Lens Designs
This study is evaluating the initial fit of toric contact lenses.
- Trial name
- NCT01552876
- Testing
- etafilcon A, nelfilcon A, Filcon II 3
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Ametropia
Three-month Clinical Evaluation of Silicone Hydrogel Definitive 65 Contact Lenses
Comparison of different contact lens materials.
- Trial name
- NCT02249689
- Testing
- Definitive 65, Definitive 74
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Contamac Ltd
Refractive Error
Wavefront-guided LASIK for Monovision Treatment of Myopic Subjects With Presbyopia
This study will be a 12-month, prospective, multicenter, open-label, non-comparative, non-randomized clinical investigation conducted at 8 to 14 sites.
- Trial name
- NCT04075591
- Testing
- iDesign Refractive Studio with STAR S4 IR® Excimer laser System
- Where
- 10 sites in United States
- Volunteers
- 219 people
- Sponsor
- AMO Development, LLC
Refractive Error, Cataract
Improving Vision and Quality of Life in the Nursing Home
The primary purpose of this study is to evaluate whether interventions to improve vision in nursing home residents have an impact on residents' health-related quality of life.
- Trial name
- NCT00347620
- Testing
- spectacles, Cataract Surgery
- Where
- 17 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
High Myopia
Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds
To evaluate and compare the effect of the prophylactic use of two different exposure times of mitomycin C (MMC) 0.02% to inhibit haze formation after photorefractive keratectomy (PRK) for high myopia (> -7.0 D).
- Trial name
- BQ-01-07-ARVO (NCT00564213)
- Testing
- PRK and a single intraoperative topical application of mitomycin C 0.02% for 15 seconds
- Volunteers
- 36 people
- Sponsor
- Instituto de Olhos de Goiania
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