Clinical trials: Erythema Nodosum Leprosum
Erythema Nodosum Leprosum, Leprosy
Montelukast in ENL Reaction
Objective of the trial is to assess the safety and efficacy of Montelukast in treatment of Erythema Nodosum leprosum (ENL) reaction in multibacillary leprosy patients either in combination with prednisolone or alone.
- Trial name
- NCT00406861
- Testing
- montelukast in treatment of ENL reaction
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- The Leprosy Mission Bangladesh
Leprosy
Prednisolone Monotherapy Versus Prednisolone Plus Methotrexate in ENL
Erythema nodosum leprosum (ENL) is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of…
- Trial name
- NCT07806357
- Testing
- Efficacy and Safety of Prednisolone Monotherapy Versus Prednisolone Plus Methotrexate in Erythema Nodosum Leprosum (Type 2 Lepra Reaction)
- Where
- Bangladesh
- Volunteers
- 19 people
- Sponsor
- Chittagong Medical College
Erythema Nodosum Leprosum, Leprosy
CC-11050 Trial in Nepalese Patients With Erythema Nodosum Leprosum
This study will be a single center, Phase 2, open-label trial to evaluate the safety and efficacy of 200mg CC-11050 administered twice daily taken with food for patients with moderate to severe ENL.
- Trial name
- NCT03807362
- Testing
- CC-11050
- Where
- 2 sites in Nepal
- Volunteers
- 50 people
- Sponsor
- The Leprosy Mission Nepal
Leprosy
Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum
Study 2B: Ciclosporin in the management of chronic or recurrent Erythema Nodosum Leprosum Aim: To assess the safety, tolerability and efficacy of Ciclosporin in the treatment of patients whose ENL is not controlled with standard…
- Trial name
- NCT00919776
- Testing
- prednisolone, ciclosporin
- Where
- Ethiopia
- Volunteers
- 20 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Erythema Nodosum Leprosum
A Study to Evaluate the Efficacy and Safety of Apremilast in Patients of Chronic and Recurrent Erythema Nodosum Leprosum
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The disease manifests with a varied spectrum, ranging from localized tuberculoid leprosy (TT) to generalized lepromatous leprosy (LL) types.
- Trial name
- NCT04822909
- Testing
- Apremilast;Apremilast;Apremilast 10 MG; 20 MG; 30 MG Oral Tablet
- Where
- 3 sites in India
- Volunteers
- 10 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Borderline Lepromatous Leprosy, Lepromatous Leprosy
Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy
This study is a double-blind, randomized controlled trial examining the effect on ENL reactions of giving an additional year of clofazimine after completion of MDT in leprosy.
- Trial name
- NCT01290744
- Testing
- Clofazimine
- Where
- Philippines
- Volunteers
- 100 people
- Sponsor
- Paul Saunderson
Leprosy
Ciclosporin in the Management of New Erythema Nodosum Leprosum
Study 2A: Ciclosporin in the management of new Erythema Nodosum Leprosum Objective: A pilot (double blind controlled) study randomizing patients to treatment either with Ciclosporin or Prednisolone to assess the safety…
- Trial name
- NCT00919542
- Testing
- Ciclosporin, prednisolone
- Where
- Ethiopia
- Volunteers
- 12 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Erythema Nodosum Leprosum
Efficacy and Safety Study of Dovramilast in People With Leprosy Type 2 Reaction
Dovramilast has not been approved for leprosy type 2 reaction (erythema nodosum leprosum, ENL) or any other disease anywhere in the world.
- Trial name
- NCT07172659
- Testing
- Dovramilast, Prednisolone, Thalidomide
- Where
- 6 sites in United States, Benin and 4 more
- Volunteers
- 45 people
- Sponsor
- Medicines Development for Global Health
Erythema Nodosum Leprosum
Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum
Erythema Nodosum Leprosum (ENL) is a painful, debilitating complication of leprosy. Patients often require high doses of corticosteroids for prolonged periods. Thalidomide is expensive and not available in most countries.
- Trial name
- MaPs (NCT03775460)
- Testing
- Methotrexate, Prednisolone
- Where
- 7 sites in Bangladesh, Brazil and 4 more
- Volunteers
- 550 people
- Sponsor
- London School of Hygiene and Tropical Medicine