Clinical trials: Erythropoietin
Ischemia-Reperfusion Injury, Myocardial Infarction
Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model
Rationale: The investigators hypothesize that EPO protects against apoptosis after acute ischemia in man and that it is detectable using the annexin-A5 model.
- Trial name
- IPIIR (NCT00691613)
- Testing
- Epoetin alpha, NaCl
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Insulin Sensitivity
Insulin Resistance and Substrate Metabolism After Acute Erythropoietin (EPO) Administration
Recently EPO receptors have been found in human muscle tissue, but what is still not known is the physiological role of these receptors.
- Trial name
- NCT00793767
- Testing
- erythropoietin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Healthy Men and Non- Pregnant Women
Influence of Erythropoietin on Bone Marrow Microenvironment
This will be a prospective observational study. The investigators will compare Erythropoietin (Epo) levels, erythropoiesis, and regulators of erythropoiesis, bone imaging and bone metabolism in healthy volunteers living at…
- Trial name
- NCT02097888
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baselland Bruderholz
Healthy
To Investigate the Pharmacokinetics of EPORON® and EPREX® After Subcutaneous Administration in Healthy Male Volunteers
This Phase I study is to compare pharmacokinetics, safety and pharmacodynamics of EPORON and EPREX after single subcutaneous administration.
- Trial name
- NCT02580006
- Testing
- EPORON, EPREX
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Healthy
PK and PD Study After Single Dose, Intravenous Administration of Two Epoetin Alfa, Eritromax and Eprex, in Healthy Subjects
The hypothesis of this trial is that the test drug (Eritromax ®) pharmacokinetics and pharmacodynamics parameters are similar to the comparator drug (Eprex ®) in healthy subjects following administration of single intravenous…
- Trial name
- NCT01664195
- Testing
- Epoetin Alfa
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Azidus Brasil
Ketosis
Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More
This study aims to address two key aspects. First, the suitability of selecting a specific sampling site for BHB measurement in patients and research, as well as potential differences between capillary and venous blood…
- Trial name
- NCT06053138
- Testing
- Ketone monoester
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Pharmacokinetics and Pharmacodynamics in Healthy Volunteers
Pharmacokinetics, Pharmacodynamics, and Safety of NANOKINE Compared With Eprex 4000 U in Healthy Volunteers
This clinical trial aims to compare the pharmacokinetic (PK), pharmacodynamic (PD) parameters, and safety between Nanokine of Nanogen Pharmaceutical Joint Stock Company and Eprex® of Janssen Cilag Ltd on healthy male volunteers.
- Trial name
- NCT06919861
- Testing
- Erythropoietin alfa
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Nanogen Pharmaceutical Biotechnology Joint Stock Company
Iron Metabolism Disorders
Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis.
- Trial name
- HEPEPO (NCT00687518)
- Testing
- Erythropoietin
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Erythropoietin, Recession
Erythropoietin Gel as an Adjunct to Split-Thickness Apically Positioned Flap in Augmentation of Attached Gingiva
This study will be carried out to evaluate the effect of topical application of erythropoietin gel as an adjunct to split-thickness apically positioned flap regarding Wound Healing and the Effect on post-surgical symptoms […
- Trial name
- NCT05683782
- Testing
- Split thickness Apically positioned flap with Chitosan based Erythropoietin Gel application, Split thickness Apically positioned flap without Erythropoietin application
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Conjunctival and Scleral Avascular Lesions
The Effect of Erythropoietin in the Treatment of Scleral Necrosis
Patients with acute avascular lesions of the conjunctiva and sclera will be included in the study. Patients will undergo a complete eye examination including a slit lamp, intraocular pressure measurement, and fundoscopy with…
- Trial name
- NCT05476042
- Testing
- Erythropoietin prescription
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Healthy
Non-erythroid Effects of Erythropoietin on Cognitive Function and Exercise Capacity in Humans
The blood hormone Erythropoietin (Epo) is not only produced by the kidneys but also by the brain, especially under hypoxic conditions. It has been shown in animal studies and human studies that Epo has neuroprotective properties.
- Trial name
- NCT01889056
- Testing
- Erythropoietin (Epoetin beta)
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Kidney Disease Requiring Hemodialysis, Chronic Kidney Disease
Serum circ_DLGAP4, lncRNA KCNQ1OT1, and Their Targets by Erythropoietin Resistance in Chronic Kidney Disease
Non-coding RNAs have evolved as biomarkers and as phased and specific therapeutic targets for chronic kidney disease (CKD). However, their clinical significance in CKD patients is largely unexplored.
- Trial name
- NCT07037953
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Alveolar Bone Loss
Evaluation of Erythropoietin on Alveolar Ridge Preservation
regenerative materials would help in decreasing post-extraction resorption in sites indicated for placement of a conventional bridge or prosthetically driven implant.
- Trial name
- NCT06513039
- Testing
- Erythropoietin carried on chitosan carrier, chitosan carrier
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Newborn Infant, Child Under One Year of Age
Study of Erythropoietin in Newborns and Children
Erythropoietin (EPO) is a glycoprotein hormone with a molecular weight of 30.4 kDa, responsible for regulating erythropoiesis in adults, newborns and fetuses.
- Trial name
- EPO (NCT03957863)
- Testing
- Plasma collection for EPO assay
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Exercise-Induced Anemia, Physical Performance
Impact of Erythropoietin on Hematological Adaptations and Physical Performance
Negative hematological adaptations due to prolonged periods of strenuous physical activity may, in part, contribute to declines in physical performance during military operations.
- Trial name
- NCT05078138
- Testing
- Epoetin Alfa
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Refractory Diabetic Macular Edema
The Effect of Intravitreal Erythropoietin Injection for Refractive Diabetic Macular Edema
after advent of RD photoreceptor degeneration Occurred. This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .
- Trial name
- NCT03821168
- Testing
- injection of bevacizumab and erythropoietin, injection of bevacizumab
- Where
- Iran
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Healthy Volunteers
Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548
The primary purpose of this study is to assess the single-dose bioavailability of AKB-6548 with ferrous sulfate relative to AKB-6548 in healthy volunteers.
- Trial name
- NCT02327546
- Testing
- AKB-6548, Ferrous Sulfate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Kidney Failure, Acute
Effect of Erythropoietin (EPO) in Kidney After Cardiac Surgery
The purpose of this study is to determine whether erythropoietin is effective in preventing acute kidney dysfunction after coronary artery bypass grafting surgery.
- Trial name
- EPO-CABG (NCT00654992)
- Testing
- Erythropoietin-Beta, Normal Saline
- Where
- South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Healthy Subjects
Effects of Recombinant Human Erythropoietin on Platelet Function in Healthy Subjects
The purpose of this study is to see if a naturally-occurring hormone called erythropoietin changes the action of platelets in the blood.
- Trial name
- NCT00368238
- Testing
- Recombinant human erythropoietin alfa (drug), Aspirin (drug), Clopidogrel (drug)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Identifying Biological Markers for Altitude Exposure and Use of Recombinant Human Erythropoietin (rHuEPO)
The project represents a well powered study of the human response to altitude exposure combined with rHuEPO treatment. A total of 20 male and 20 female non-competing athletes will participate.
- Trial name
- NCT04227665
- Testing
- Sea level, Altitude
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen