Clinical trials: Erythropoietin
Red-Cell Aplasia, Pure
A Study to Observe the Number of Patients Who Develop Pure Red Cell Aplasia (PRCA, a Rare Form of Anemia) While Receiving Epoetin Alfa or Other Recombinant Erythropoietins
The purpose of this study is to record the number of participants with chronic renal disease who are receiving treatment with epoetin alfa or other recombinant erythropoietins who develop pure red cell aplasia (PRCA, a rare form…
- Trial name
- NCT00211029
- Volunteers
- 4,670 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetes, Chronic Kidney Insufficiency
Prevention of Contrast Induced Nephropathy by Erythropoietin
This ia a prospective, randomized, double blind, placebo controlled trial. patients schedule for primary PCI or elective PCI will randomly allocated to receive either a single dose of EPO (Recormon, Roche, Epoetin beta) or saline…
- Trial name
- NCT01364402
- Testing
- Epoetin beta, Saline 0.9%
- Where
- Israel
- Volunteers
- 142 people
- Sponsor
- Western Galilee Hospital-Nahariya
Stroke
REGENESIS (US): A Phase IIb Prospective, Randomized, Double-blind, Placebo Controlled Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
To assess the safety and tolerability of NTx™-265 when given to acute ischemic stroke patients. To assess the neurological outcome in acute ischemic stroke patients treated with NTx™-265, when compared with patients given a…
- Trial name
- REGENESIS (NCT00715364)
- Testing
- NTx™-265: rhCG, then rEPO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Stem Cell Therapeutics Corp.
Chronic Renal Failure, Chronic Kidney Disease
Safety & Efficacy of Peginesatide for Maintenance Treatment of Anemia in Participants With Chronic Kidney Disease on Hemodialysis
The purpose of this study was to evaluate the safety and efficacy of peginesatide in the maintenance treatment of anemia in participants on dialysis.
- Conditions
- Chronic Renal Failure, Chronic Kidney Disease, Anemia
- Trial name
- EMERALD 2 (NCT00597584)
- Testing
- peginesatide, Epoetin alfa or Epoetin beta
- Where
- 84 sites in United States, Bulgaria and 7 more
- Volunteers
- 823 people
- Sponsor
- Affymax
Acute Mountain Sickness
Erythropoietin in the Prevention of Acute Mountain Sickness
Acute mountain sickness (AMS) is a syndrome of nonspecific symptoms and is therefore subjective. The Lake Louise Consensus Group defined acute mountain sickness as the presence of headache in an unacclimatized person who has…
- Trial name
- EPO-AMS (NCT01665781)
- Testing
- Erythropoietin
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Ulsan
Anemia
Erythropoietin Alfa in Elderly Subjects With Unexplained Anemia
The primary objective of this study is to assess the ability of epoetin alfa to raise hemoglobin (Hb) levels in elderly outpatients with unexplained anemia.
- Trial name
- NCT00954486
- Testing
- Epoetin alfa
- Where
- 3 sites in United States
- Sponsor
- Stanford University
Anemia, Chronic Kidney Disease (CKD)
Study to Compare Safety and Efficacy of HX575 Epoetin Alfa and US-licensed Epoetin Alfa
The purpose of this study is to show biosimilarity of HX575 epoetin alfa with the US licensed reference product Epogen®/Procrit® when applied subcutaneously.
- Trial name
- ACCESS (NCT01693029)
- Testing
- HX575 epoetin alfa, US-licensed epoetin alfa
- Where
- 52 sites in United States
- Volunteers
- 435 people
- Sponsor
- Sandoz
Parkinson Disease
Safety Study of Erythropoietin (EPO) in Parkinson's Disease
The purpose of this study is to determine whether recombinant human Erythropoietin (EPOrh) is safe in the treatment of patients with Parkinson's Disease.
- Trial name
- NCT01010802
- Testing
- Erythropoietin human recombinant (EPOrh)
- Where
- Cuba
- Volunteers
- 10 people
- Sponsor
- International Center for Neurological Restoration, Cuba
Cancer
Procrit Versus Placebo to Determine Efficacy in Pre-Operative Major Surgical Oncology Operations
The purpose of this study is to evaluate the effectiveness of a two-dose regimen of Procrit prior to a major surgical oncology operation.
- Trial name
- NCT00624312
- Testing
- Procrit
- Where
- United States
- Sponsor
- University of Louisville
Anemia, Dialysis-Dependent Chronic Kidney Disease
Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents
This is a Phase 2, randomized, open-label study to evaluate vadadustat versus epoetin alfa for the treatment of anemia in subjects with Dialysis-dependent Chronic Kidney Disease (DD-CKD) who are hyporesponsive to erythropoiesis…
- Trial name
- NCT03140722
- Testing
- vadadustat, epoetin alfa
- Where
- 18 sites in United States
- Volunteers
- 2 people
- Sponsor
- Akebia Therapeutics
Healthy
Can Erythropoietin Protect the Cerebral Blood Flow and Oxygenation During Simulated Dive?
During facial cooling and especially during breath hold, can mammals - and also humans - elicit a so called dive reflex, causing bradycardia, peripheral vasoconstriction and centralization of blood flow to brain, lungs and heart…
- Trial name
- NCT00265486
- Testing
- Recombinant human Erythropoietin
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Thrombosis, Hypertension
Erythropoietin and Platelet Activation Markers
We hypothesized that the effect of erythropoietin may be reflected by changes in thromboxane B2 (TXB2) and endothelial cell function.
- Trial name
- NCT01392612
- Testing
- erythropoietin
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Anemia Renal
Pentoxifylline Administration in Hemodialysis Patients
The aim of the study is to assess the impact of pentoxifylline administration on the modulation of hyporesponsiveness to erythropoietin stimulating agents in hemodialysis patients
- Trial name
- NCT03800433
- Testing
- Trental 400 MG Extended Release Oral Tablet
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Traumatic Brain Injury
Safety Study of Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Traumatic Brain Injury: Dosing Tier 1
Prospective, Open Label, Cohort Study in Traumatic Brain Injury Patients. The goal of this study is to assess the safety of NTx®-265.
- Trial name
- NCT01239706
- Testing
- NTx 265
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Pharmacokinetics, Erythropoietin
Intraocular Pharmacokinetics of Erythropoietin After Single Intravitreal Injection in Human
The investigators investigate intraocular concentrations and pharmacokinetics of erythropoietin after a single intravitreal injection in humans.
- Trial name
- NCT01131533
- Testing
- Vitrectomy
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Hallym University Medical Center
Anemia, Dialysis-Dependent Chronic Kidney Disease
Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)
A multicenter, randomized, open-label, active-controlled Phase 3 study for the correction or maintenance treatment of anemia in participants with incident dialysis-dependent chronic kidney disease (DD-CKD).
- Trial name
- NCT02865850
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 118 sites in United States, Argentina and 9 more
- Volunteers
- 369 people
- Sponsor
- Akebia Therapeutics
Anemia - Cancer Related
An Observational Study to Predict the Response of Erythropoietin Treatment in Participants With Cancer Related Anemia Receiving Chemotherapy
The purpose of this observational study is to evaluate the predictors of response to erythropoietin (hormone secreted by kidney that helps in formation of red blood cells in bone marrow) treatment in participants with cancer…
- Trial name
- NCT01736215
- Testing
- Erythropoietin: Observational study
- Where
- 3 sites in Thailand
- Volunteers
- 33 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Healthy Subjects
Study on Single Administration and Dose Increment of Recombinant Human Serum Albumin/Erythrocyte Fusion Protein for Injection
The purpose of the study was to evaluate the safety of rHSA/EPO to healthy subjects and to investigate the pharmacokinetic characteristics of rHSA/EPO in healthy subjects, and to obtain preliminary pharmacokinetic parameters.
- Trial name
- NCT03786289
- Testing
- Recombinant human serum albumin/erythropoietin fusion protein, Recombinant erythropoietin injection (CHO cells)
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Tianjin SinoBiotech Ltd.
Periodontal Disease, Chronic Kidney Disease
The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients
Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998).
- Trial name
- PAROHEM (NCT01785355)
- Testing
- Dental treatment
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Anemia Working Group Romania
Anemia, Sepsis
Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a Randomized Controlled Trial
Background Up to 66% of have anemia at the admission to the intensive care unit. This number increases to 95% after 72 hours of hospitalization in the intensive care unit due to illness and iatrogenic blood loss.
- Conditions
- Anemia, Sepsis, Septic Shock
- Trial name
- EpoAid (NCT06670963)
- Testing
- Iron, EPO, 0.9 % NaCl
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Piotr Czempik