Clinical trials: Esophageal Achalasia
Achalasia, Hypertensive LES
Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Esophageal Motility Disorders
Spastic esophageal motility disorders induced significant symptoms including dysphagia, retrosternal pain and regurgitation. Per oral endoscopic myotomy (P.O.E.M.) is a novel approach to perform myotomy through the esophagus with…
- Trial name
- POEM (NCT01525732)
- Testing
- Per Oral Endoscopic Myotomy
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Achalasia
Evaluation of a Novel Endoscopic Treatment for Achalasia
This study is to evaluate outcomes of a less invasive surgical procedure for the treatment of achalasia.
- Trial name
- POEM (NCT01770249)
- Testing
- Per-oral Endoscopic Esophagomyotomy (POEM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Achalasia, Esophageal
Metabolic Changes Associated With Weight Gain After Treatment of Achalasia
This goal of the study is to assess the effect of weight gain in patients with achalasia after they are treated. The main question to be answered is if weight gain after achalasia treatment is associated with worsening metabolic…
- Trial name
- NCT07334639
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Esophagus Disorder
Risk Factors for Sub Mucosal Fibrosis During Achalasia Cardia: A Prospective Study
Classification for Stasis Esophagitis: Grade I Grade II Grade III Vascular pattern Obscured Obscured Obscured Mucosal thickening No Yes Yes Ulceration No Yes Yes Nodularity No No Yes
- Trial name
- NCT06815341
- Where
- 2 sites in India
- Volunteers
- 339 people
- Sponsor
- Asian Institute of Gastroenterology, India
Esophageal Diseases
Standard Versus Oesophago-gastric Junction Complex Myotomy for Treatment naïve Type 2 Achalasia Patients
Consecutive eligible patients will be randomized in a 1:1 ratio to esophagogastric complex only myotomy or standard myotomy groups. Randomization is done according to the computer-generated algorithm.
- Trial name
- NCT06870630
- Testing
- Per oral endoscopy myotomy
- Where
- India
- Volunteers
- 158 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction
The Impact of Anesthetics on FLIP
To understand the impact of commonly used anesthetics on esophageal motility during FLIP topography.
- Conditions
- Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction, Spastic Esophageal Disorders
- Trial name
- NCT07458555
- Testing
- FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Achalasia
VZV in the Enteric Nervous System: Pathogenesis and Consequences
Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles").
- Trial name
- NCT05550194
- Testing
- ValACYclovir 1000 MG, Shingrix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Achalasia
Comprehensive Esophageal Diagnostics Study
The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry)…
- Trial name
- NCT04641702
- Testing
- Atropine challenge, Esophageal muscle biopsy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Achalasia
Sensorimotor Dysfunction in Achalasia
This study is being done to assess the esophageal muscle (swallowing tube) in patients with and without achalasia to further understand and help direct the treatment for patients with achalasia.
- Trial name
- NCT02434991
- Testing
- Barostat
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
Esophageal Motility Disorders
Monopolar and Bipolar Current RFA Knife in POEM
Per Oral Endoscopic Myotomy (POEM) is performed for various esophageal muscular disorders, including achalasia and other spastic esophageal conditions.
- Trial name
- NCT05272046
- Testing
- Per-oral Endoscopic Myotomy, Speedboat (Bipolar electrocautery knife)
- Where
- 3 sites in United States, India and 1 more
- Volunteers
- 104 people
- Sponsor
- Baylor College of Medicine
Achalasia, EGJ Outflow Obstruction
Safety and Efficacy of a Novel SpydrBlade Flexible Bipolar in POEM
Achalasia is an idiopathic motility disorder, primarily identified by the absence of esophageal peristalsis and the inability of the lower esophageal sphincter (LES) to relax properly.
- Trial name
- NCT07406945
- Testing
- SpydrBlade Flex
- Where
- 2 sites in Ecuador, Hong Kong
- Volunteers
- 73 people
- Sponsor
- Chinese University of Hong Kong
Achalasia
Peroral Endoscopic Myotomy (POEM) for Esophageal Motility
The investigators wish to monitor the adoption of a new, incisionless approach to performing a Heller myotomy for the surgical treatment of achalasia.
- Trial name
- POEM (NCT02314741)
- Testing
- POEM Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Achalasia, Achalasia Cardia
Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy
Peroral endoscopic esophagel myotomy (POEM) is a third space endoscopy technique that depends on creating a submucosal tunnel to expose the esophageal muscle and eventually perform an esophageal myotomy.
- Trial name
- NCT06189859
- Testing
- endoscopic submucosal dissection using SPRAY COAG mode, endoscopic submucosal dissection using Precisect mode
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Achalasia
Short Vs Standard Length Myotomy in Achalasia
The objective of this randomized controlled trial (non-inferiority study) is to evaluate the outcomes of 4 cm short myotomy compared to the 8 cm standard length myotomy in Per-Oral Endoscopic Myotomy (POEM) for patients with…
- Trial name
- NCT04798547
- Testing
- Short Myotomy, Standard Length Myotomy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Achalasia Cardia, GERD (Gastroesophageal Reflux Disease)
Biological Optimization Versus Standard Care in Post-POEM Achalasia Patients (BIO-POEM)
This study aims to evaluate whether a structured biological optimization program can improve reflux symptoms and overall recovery in patients with achalasia cardia who previously underwent Peroral Endoscopic Myotomy (POEM).
- Trial name
- BIO-POEM 1 (NCT07620899)
- Testing
- Structured Biological Optimization
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia, Achalasia Cardia
Nasogastric Tube After Laparoscopic Heller-Dor Myotomy
The goal of this prospective observational study is to evaluate the role of nasogastric tube (NGT) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Trial name
- NCT05729971
- Testing
- nasogastric tube
- Where
- Italy
- Volunteers
- 79 people
- Sponsor
- Federico II University
Primary Achalasia
Peroral Endoscopic Myotomy for Primary Esophageal Achalasia
Recommended therapies for esophageal achalasia are endoscopic pneumatic dilation and Heller-Dor surgical myotomy. Endoscopic myotomy has been recently proposed in human patient in expert centers in Japan, US and Germany.
- Trial name
- TAMEO (NCT01560559)
- Testing
- Peroral endoscopic myotomy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Hospices Civils de Lyon
Esophageal Cancer Surgery, Esophagectomy
Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy
The goal of this pragmatic, registry-based, randomized clinical trial is to find out if using botulinum toxin (Botox) to help drain the stomach during an esophagectomy works as well as a pyloromyotomy in patients undergoing…
- Conditions
- Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure, Esophageal Diseases
- Trial name
- EMPTY (NCT06721520)
- Testing
- Botulinum Toxin A (Botox ), Pyloromyotomy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- The Cleveland Clinic