Clinical trials: Esophageal Achalasia
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Achalasia, Achalasia Cardia
Nasogastric Tube After Laparoscopic Heller-Dor Myotomy
The goal of this prospective observational study is to evaluate the role of nasogastric tube (NGT) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Trial name
- NCT05729971
- Testing
- nasogastric tube
- Where
- Italy
- Volunteers
- 79 people
- Sponsor
- Federico II University
Esophageal Achalasia
Short Versus Long Submucosal Tunneling in Per-oral Endoscopic Myotomy (POEM) for Type II Achalasia.
this study is prospective , randomized and interventional ,will be performed on 50 patients to compare the clinical utility , safety profile and postoperative recovery metrics between short and long per-oral endoscopic myotomy …
- Trial name
- NCT07686471
- Testing
- per-oral endoscopic myotomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features
PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions.
- Conditions
- Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features, Jackhammer Esophagus, Distal Esophageal Spasm
- Trial name
- PREMEDIA (NCT07293689)
- Where
- 16 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Achalasia
Peroral Endoscopic Myotomy for the Treatment of Achalasia
There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 \& a prospective chart review will be performed for patients who will undergo endoscopic procedures and…
- Trial name
- NCT04640753
- Testing
- Endoscopic procedure for achalasia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Methodist Health System
Esophageal Motility Disorders
Endolumenal Partial Myotomy for Esophageal Motility Disorders
Achalasia and esophageal spasm are primary esophageal motility disorders where the lower esophageal sphincter fails to relax in response to swallowing with no well understood underlying cause.
- Trial name
- NCT01302301
- Testing
- Per oral endolumenal myotomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Oregon Clinic
Achalasia
Peroral Endoscopic Myotomy (POEM) for Esophageal Motility
The investigators wish to monitor the adoption of a new, incisionless approach to performing a Heller myotomy for the surgical treatment of achalasia.
- Trial name
- POEM (NCT02314741)
- Testing
- POEM Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Weight Gain, Nutritional Imbalance
COMPREHENSIVE ANALYSIS OF NUTRITIONAL PARAMETERS IN PATIENTS WITH IDIOPATHIC ACHALASIA: A PROSPECTIVE STUDY.
A total of 100 patients aged 18-60 years with confirmed diagnosis of achalasia cardia will be recruited prospectively. In this study, patients diagnosed with achalasia cardia (prior to per oral endoscopic myotomy treatment) will…
- Trial name
- POEM (NCT05161923)
- Testing
- Per oral endoscopy myotomy
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia
Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia
This is a study of the safety and efficacy of a new surgical procedure using endoscopic instruments and a tunneling technique to reach the LES for dissection.
- Trial name
- POEM (NCT01399476)
- Testing
- Endoscopic Myotomy, Endoscopic Myotomy for treatment of achalasia
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The Oregon Clinic
Cricopharyngeal Achalasia, Dysphagia
Effect of Botulinum Toxin Injection Guided by Ultrasound Combined With Balloon Localization on Cricopharyngeal Achalasia
cricopharyngeal achalasia refers to incomplete or non-open functional opening of the cricopharyngeal muscle, and after repeated swallowing of food, it still cannot pass through the cricopharyngeal muscle, remaining in the…
- Trial name
- NCT06213662
- Testing
- Botulinum toxin type A for injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Achalasia
Efficacy of Dark Chocolate in Achalasia Patients
Flavanols, present in dark chocolate, were shown to induce Nitric Oxide synthesis. Since Nitric Oxide facilitates smooth muscle relaxation, it might ease the relaxation of the LES (lower esophageal sphincter)as well.
- Trial name
- NCT00790465
- Testing
- dark chocolate
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Achalasia
redoPOEM : Failure of a First POEM
observational study, measurement of efficacy in the cohort.
- Trial name
- redoPOEM (NCT06044155)
- Where
- 14 sites in France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Bordeaux
Esophageal Motility Disorders
The Clinical Manifestation and Prognosis of Pediatric Esophageal Motility Disorders
Background: Abnormal esophageal peristalsis mostly occurs in adults, but some patients have onset in childhood. Most of the symptoms of esophageal motility disorders in children are not as clear as those described by adult…
- Trial name
- NCT06629025
- Testing
- High-resolution impedance manometry
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Esophageal Achalasia
Assessment of the Neuro-glio-epithelial Unit (NGEU) in Biopsies Taken During Peroral Endoscopic Myotomy (POEM) for Achalasia: a Feasibility and Safety Study.
Achalasia is a primary esophageal motility disorder characterized on high-resolution manometry (HRM) studies by 100% failed peristalsis and elevated integrated relaxation pressure of the lower esophageal sphincter.
- Trial name
- Achalaglie (NCT04112693)
- Testing
- Esophageal biopsies during Peroral Endoscopic Myotomy (POEM)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Nantes University Hospital
Achalasia
Risk of Microbial Translocation in Patients Undergoing Per-Oral Endoscopic Myotomy (POEM) for Achalasia: Antibiotic Prophylaxis or Short-therapy
Background: Achalasia is a primary rare esophageal motor disorder of the esophagus (annual incidence of 1:100,000 persons). Recently, a new endoscopic technique, Per-Oral Endoscopic Myotomy (POEM), has been introduced with…
- Trial name
- POEM-MT01 (NCT03587337)
- Testing
- POEM
- Where
- Italy
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Achalasia, Esophageal
Metabolic Changes Associated With Weight Gain After Treatment of Achalasia
This goal of the study is to assess the effect of weight gain in patients with achalasia after they are treated. The main question to be answered is if weight gain after achalasia treatment is associated with worsening metabolic…
- Trial name
- NCT07334639
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center