Clinical trials: Esophageal Atresia
Esophageal Atresia
Individualized Management for Long Gap Esophageal Atresia
The treatment of long gap esophageal atresia (LGEA) in neonates is one of the most challenging congenital malformations in neonatal surgery.
- Trial name
- NCT03023865
- Testing
- Staged stress function
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Esophageal Atresia, Anastomotic Stenosis
Oral Viscous Budesonide in Anastomotic Stricture After Esophageal Atresia Repair (OVB in EA)
The aim of this study is to perform a multicentre, prospective, randomized, placebo controlled, double-blinded study to demonstrate the potential and beneficial effects of OVB in the prevention of recurrence of anastomotic…
- Trial name
- OVB in EA (NCT03999008)
- Testing
- Budesonide Oral
- Volunteers
- 60 people
- Sponsor
- St. Justine's Hospital
Esophageal Atresia
High-resolution Esophageal Manometry
EA is one of the most frequent birth defects, with an incidence of 1 in 3000 live births1. Until the 1950s, these patients had 100% mortality; nowadays, the survival rate is greater than 90%, and only those with associated severe…
- Trial name
- NCT03415893
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Hospital El Cruce
Esophageal Atresia
Molecular Signatures of Esophageal Atresia
Although several studies have revealed signaling pathways as well as genes potentially involved in the development of esophageal atresia (EA), our understanding of the pathophysiology of EA lags behind improvements in the…
- Trial name
- NCT06073158
- Testing
- Esophageal biopsy collection during anastomosis
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Esophageal Atresia
Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence
Oesophageal atresia (OAEA), a malformation of the oesophagus present from birth, is characterized by the interruption of the continuity of the oesophagus, which then ends in a cul-de-sac.
- Trial name
- TransEAsome (NCT05995171)
- Testing
- Questionnaire
- Where
- 33 sites in France, Martinique and 1 more
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Esophageal Atresia
Brazilian Multicenter Study on Esophageal Atresia
Esophageal atresia is a congenital malformation where the esophagus does not form properly, often associated with a tracheoesophageal fistula. This condition requires complex surgical treatment and intensive neonatal care.
- Trial name
- NEOBRA-EA (NCT07210736)
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- University of Sao Paulo General Hospital
Tracheo-Esophageal Fistula with Atresia of Esophagus
Use of Indocyanine Green During Primary Repair of Oesophageal Atresia and Distal Tracheo-oesophageal Fistula
This study aims to look at babies having a primary or delayed primary oesophageal repair for OA with dTOF to evaluate if using Indocyanine green (ICG) and near infrared fluorescence (NIRF) can decrease the rates of anastomotic…
- Trial name
- iTOF (NCT05735964)
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London