Clinical trials: Esophageal Atresia
Oesophageal Atresia, Dumping Syndrome
Dumping Syndrome and Esophageal Atresia
Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood.
- Trial name
- DUMTORING (NCT04522193)
- Testing
- Glycemic Holter, gastric emptying scintigraphy, Holter ECG
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Tracheoesophageal Fistula, Esophageal Atresia With Tracheo-esophageal Fistula
Camera-based Endoscopy Allows Spontaneous Breathing Diagnostic Management in Neonates With Tracheoesophageal Fistula
The investigators aim to compare rigid tracheoscopy versus flexible tracheo-video-endoscopy in neonates requiring diagnostic assessment before undergoing a congenital tracheoesophageal fistula repair.
- Trial name
- CBESB (NCT07687628)
- Testing
- tracheoscopy performed with rigid optical tracheoscopy, flexible video endoscopy of trachea
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Papa Giovanni XXIII Hospital
Esophageal Atresia
Prospective Evaluation of the Results of Multidisciplinary Follow-up After a Transitional Consultation for Esophageal Atresia
A transition consultation for adult patients with esophageal atresia, involving medical and paramedical stakeholders, was set up at Hôpital Saint-Louis in 2020. The aim of this initiative is to: 1.
- Trial name
- TAO (NCT06860919)
- Testing
- Follow-up of the patients during 3 years
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Esophageal Atresia, Oesophageal Atresia
Evaluation of the Respiratory Impact After Conventional or Minimally Invasive Esophageal Atresia Surgery
Right thoracotomy, conventional approach to esophageal atresia repair, leads to up to 60% radiological chest wall sequelae anomalies. The impact of these anomalies on the patient's respiratory function remains unknown.
- Conditions
- Esophageal Atresia, Oesophageal Atresia, Restrictive Lung Disease, Chest Wall Anomaly
- Trial name
- RestriMIS (NCT04136795)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Antenatal Management of the Fetal Gastrointestinal Atresia
Prenatal Diagnosis of the Fetal Esophageal or Intestinal Atresia
Aim- to investigate how prenatal diagnosis of fetal esophageal or intestinal atresia impacts obstetric and neonatal outcomes. Methods- This was a retrospective cohort study at a single center.
- Trial name
- DANATRESIA (NCT05362604)
- Testing
- scheduled delivery at a tertiary center
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Esophageal Atresia
Cardiorespiratory Performance and Pulmonary Microbiome in Patients After Repair of Esophageal Atresia
The majority of the clinical research on esophageal atresia focuses on the upper gastrointestinal tract. However, the trachea and the lung are also affected in many of these children, so that a lifelong pulmonary impairment may…
- Trial name
- NCT03767673
- Testing
- Initial Spirometry, Final Spirometry, Pulmonary microbiome (16S rDNA profiling)
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Esophageal Atresia
Individualized Management for Long Gap Esophageal Atresia
The treatment of long gap esophageal atresia (LGEA) in neonates is one of the most challenging congenital malformations in neonatal surgery.
- Trial name
- NCT03023865
- Testing
- Staged stress function
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus
Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair
Azygos vein preservation revisited: impact on early outcomes after repair of Esophageal atresia/ Tracheo-Esophageal Fistula in newborns. A randomized controlled study.
- Conditions
- Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus, Leak, Anastomotic, Stricture Esophagus
- Trial name
- EArAzygousvp (NCT05957562)
- Testing
- EA/TOF primary repair with Azygos vein preservation, EA/TOF primary repair with Azygos vein sacrifice (disconnection)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Esophageal Atresia, Healthy Children
Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers
Esophageal atresia is the most common congenital anomaly of the esophagus and is caused by abnormal development of the esophagus during intrauterine life.
- Trial name
- NCT06975982
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Esophageal Varices
Wired Magnetically Assisted Capsule Endoscopy and Esophageal Varices
The goal of this clinical trial is to compare the safeness and effectiveness of traditional esophagogastroduodenoscope (EGD) and wired magnetically assisted capsule endoscopy (MACE) in the diagnosis of esophageal varices in…
- Trial name
- NCT06017102
- Testing
- wired magnetic assisted capsule endoscopy, esophagogastroduodenoscopy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Esophageal Atresia
Brazilian Multicenter Study on Esophageal Atresia
Esophageal atresia is a congenital malformation where the esophagus does not form properly, often associated with a tracheoesophageal fistula. This condition requires complex surgical treatment and intensive neonatal care.
- Trial name
- NEOBRA-EA (NCT07210736)
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- University of Sao Paulo General Hospital
Gastroschisis, Congenital Diaphragmatic Hernia
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels
The SuNDiAL study will measure levels of two naturally occurring amino acids: Arginine and Asymmetric Dimethylarginine (ADMA) in neonates undergoing abdominal surgery in the first 5 days of life due to congenital abdominal…
- Conditions
- Gastroschisis, Congenital Diaphragmatic Hernia, Duodenal Atresia, Oesophageal Atresia With Tracheo-Oesophageal Fistula
- Trial name
- SuNDiAL (NCT06731855)
- Testing
- Abdominal Surgery for congenital gut malformation in the first 5 days of life.
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Liverpool Women's NHS Foundation Trust
Esophageal Atresia, Digestive System Abnormalities
Flourish™ Pediatric Esophageal Atresia
This study is continued evaluation of the safety and probable benefit of the Flourish Pediatric Esophageal Atresia device through the Humanitarian Device Exemption (HDE) pathway.
- Conditions
- Esophageal Atresia, Digestive System Abnormalities, Esophageal Disorders Congenital
- Trial name
- NCT03615495
- Testing
- Flourish Pediatric Esphogeal Atresia device
- Where
- 12 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- Cook Research Incorporated
Esophageal Atresia
Respiratory Complications of Operated Esophageal Atresia in Children
The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal…
- Trial name
- ATRESIA (NCT05527873)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Strasbourg, France
Esophageal Atresia, Esophagitis
Management of Esophagitis Following Repair of Esophageal Atresia
The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia.
- Trial name
- NCT03619408
- Testing
- Antacids
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Esophageal Atresia
Esophageal Atresia: a Natural Experiment of the Effects of Oral Inoculation on the Gut Microbiome
The purpose of this study is to understand changes of the gut microbiome due to esophageal atresia. The intervention will be to give a patient his or her own saliva through their gastrostomy tube (directly into the stomach) to…
- Trial name
- NCT04901546
- Testing
- Patient's own saliva
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Stanford University
One Lung Ventilation OLV, Esophageal Atresia
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.
The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be…
- Conditions
- One Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, Pneumonectomy
- Trial name
- RCT (NCT04932746)
- Testing
- Dexmedetomidine
- Where
- Syria
- Volunteers
- 110 people
- Sponsor
- Damascus University
Gastroesophageal Reflux, Esophageal Atresia
Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
The purpose of this study is to compare the efficacy of oral and rectal omeprazole treatment in infants with gastroesophageal reflux due to esophageal atresia or congenital diaphragmatic hernia.
- Conditions
- Gastroesophageal Reflux, Esophageal Atresia, Hernia, Diaphragmatic
- Trial name
- NCT00226044
- Testing
- Omeprazole rectally 1mg/kg
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Rijnstate Hospital
Esophageal Atresia
High-resolution Esophageal Manometry
EA is one of the most frequent birth defects, with an incidence of 1 in 3000 live births1. Until the 1950s, these patients had 100% mortality; nowadays, the survival rate is greater than 90%, and only those with associated severe…
- Trial name
- NCT03415893
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Hospital El Cruce