Clinical trials: Esophageal Disease
Clinical or Oncologic Benefits of Robot-assisted IVOR-LEWIS in Esophageal Cancer
Robot-assisted IVOR-LEWIS Esophagectomy
Minimally invasive esophagectomy (MIE) have become increasingly popular in esophageal cancer. It is generally accepted that comparing to open resections, MIE results in decreased postoperative pain, faster recovery times, and…
- Trial name
- RAILE (NCT03140189)
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Ruijin Hospital
GERD in Children, GERD
The Study of Nutrition of Children and Adolescents With GERD
This trial is to study the aspects of nutrition in children and adolescents with GERD compared to the sex and age-matched control group
- Trial name
- NCT04202276
- Testing
- diet assessment
- Where
- Russia
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Esophageal Neoplasms
A Trial of CMNa Combined With Preoperatie Concurrent Chemoradiotherapy for Locally Advanced ESCC
This is a perspective, multicenter,single arm, open label study to evaluate the efficacy and safety of treatment with CMNa combined with preoperatie concurrent chemoradiotherapy in patients with locally advanced squamous cell…
- Trial name
- NCT02721550
- Testing
- Sodium Glycididazole
- Where
- 9 sites in China
- Volunteers
- 2 people
- Sponsor
- Shandong Cancer Hospital and Institute
Esophagus Cancer
The Effect of Parenteral Nutrition Supplement on Esophagectomy Patients
Malnutrition is common in esophagus cancer patients, especially after surgery therapy. Whether parenteral supplement with enteral nutrtion is benificial for patients after esophagectomy is controversial, when compared with…
- Trial name
- NCT01669356
- Testing
- Parenteral supplement with enteral nutrition for patients after esophagectomy, Enteral Nutrition alone for patients after esophagectomy
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Shanghai Zhongshan Hospital
Candidiasis, Oral
Trial of Two Dosing Regimens of Micafungin Versus Caspofungin for the Treatment of Esophageal Candidiasis
To determine the efficacy and safety of daily doses of IV micafungin versus IV caspofungin for the treatment of esophageal candidiasis
- Trial name
- NCT00665639
- Testing
- micafungin, caspofungin
- Where
- 31 sites in Argentina, Brazil and 2 more
- Volunteers
- 454 people
- Sponsor
- Astellas Pharma Inc
Oesophagus Cancer
Effects of a Training Intervention After Thoracoabdominal Oesophagus Surgery
This study evaluates the effect of a training intervention after thoracoabdominal resection of the oesophagus. Half of the patients scheduled for thoracoabdominal oesophagus surgery were randomized to an intervention group while…
- Trial name
- NCT02335970
- Testing
- Training group
- Volunteers
- 64 people
- Sponsor
- Göteborg University
Esophageal Achalasia
Study on the Relationship Between Pathological Features of Achalasia and Prognosis of Per-oral Endoscopic Myotomy
Achalasia is the most common motility disorder of esophagus, characterized by disorders of the lower esophageal sphincter (LES).
- Trial name
- NCT05113173
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fandong Meng
Dysphagia
Effect of Acupuncture Therapy on Dysphagic Parkinson's Patients
We are currently conducting a randomized controlled study in China, specifically in three hospitals' rehabilitation medicine departments, focusing on dysphagic participants with Parkinson's disease.
- Trial name
- NCT06255756
- Testing
- Routine rehabilitation training, Swallowing rehabilitation training, Acupuncture therapy
- Where
- China
- Sponsor
- Zeng Changhao
Gastro Esophageal Reflux
Effect of Magnesium Alginate in Infants With Gastroesophageal Reflux.
Recurrent regurgitation stress the infants and their parents and often results in an inappropirate use of PPI prescription in infancy.
- Trial name
- NCT03881722
- Testing
- Mg alginate
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Esophageal Neoplasms
A Study of Second-line Treatment of Postoperative Recurrence and Metastasis of Esophageal Cancer Treated With Apatinib
A study of second-line treatment of postoperative recurrence and metastasis of esophageal squamous cell carcinoma after chemotherapy with apatinib mesylate
- Trial name
- NCT03787251
- Testing
- Apatinib, The chemotherapeutic drug chosen by the investigator.
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Esophageal Cancer
Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer
The purpose of this study is to investigate the effect of concurrent chemoradiation therapy on respiratory muscle performance, lung function and functional capacity in patients with local esophagus cancer.
- Trial name
- NCT03120572
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Mackay Memorial Hospital
Gastric Cancer, Gastroesophageal Junction Cancer
A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancer
The purpose of this study is to find out whether it is better to receive a new drug, BBI608, in addition to paclitaxel chemotherapy or better to receive paclitaxel chemotherapy alone as second line treatment for gastric and…
- Trial name
- BRIGHTER (NCT02178956)
- Testing
- BBI608, Paclitaxel
- Where
- 263 sites in United States, Australia and 20 more
- Volunteers
- 714 people
- Sponsor
- Sumitomo Pharma America, Inc.
Patients With Typical Symptoms of GERD (GERD Q >= 8)
Proton Pump Inhibitor Empirical Treatment in Management of Outpatients With Gastroesophageal Reflux Disease.
China Survey of Proton Pump Inhibitor Empirical Treatment in Management of Outpatients with Gastroesophageal Reflux Disease
- Trial name
- NCT02606851
- Where
- 10 sites in China
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Esophageal Squamous Cell Carcinoma
Comparing 61.2 Gy Radiotherapy Dose Versus 50.4 Gy Radiotherapy Dose for Locally Advanced Esophageal Carcinoma
The purpose of this study is to determined the best definitive radiotherapy dosage for patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT03790553
- Testing
- Radiotherapy
- Where
- 3 sites in China
- Volunteers
- 646 people
- Sponsor
- Fudan University
Esophageal Neoplasms
Efficacy Study on the Transfer of Adenovirus With the CD40 Ligand Gene (AdcuCD40L) to Patients With Esophageal Carcinoma
This study is a randomized, double-blinded assessment of biologic efficacy of AdcuCD40L. The individuals enrolled in this study will be individuals with biopsy proven resectable esophageal carcinoma.
- Trial name
- cd40 (NCT00504322)
- Testing
- AdcuCD40L
- Sponsor
- Weill Medical College of Cornell University
Gastroesophageal Reflux Disease
Study to Compare Different Formulations of AZD3355
The purpose of the study is to compare different formulations of AZD3355 in regard to possible adverse events such as sensations of numbness, tinglings and heat in the skin.
- Trial name
- NCT00688402
- Testing
- AZD3355
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cancer Survivor, Dysphagia
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors
This trial studies how well manual therapy works in treating fibrosis-related late effect dysphagia in head and neck cancer survivors.
- Conditions
- Cancer Survivor, Dysphagia, Fibrosis, Head and Neck Carcinoma
- Trial name
- MANTLE (NCT03612531)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Oropharyngeal Dysphagia
Investigation of a Free Water Protocol
Hypothesis: Use of a Free Water Protocol (FWP) will improve patient satisfaction scores (Dysphagia Handicap Index), will not increase the risk of aspiration pneumonia/pneumonitis, and will result in improved oral hygiene (as…
- Trial name
- NCT06309602
- Testing
- Free Water Protocol, Control / Standard Care
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Poudre Valley Health System
Oesophageal Cancer
Gastrointestinal Functional Outcome Ivor Lewis
This study focuses on the prevalence of functional complications and their impact on QOL in patients who underwent an Ivor Lewis Oesophagectomy.
- Trial name
- NCT03658837
- Testing
- Ivor Lewis Oesophagectomy
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University Hospitals, Leicester
Head and Neck Cancer, Dysphagia
Training Swallowing Initiation During Expiration
Head and neck cancers have escalated to epidemic levels in the United States, and survivors are suffering from life-long, devastating swallowing disorders with limited therapeutic options.
- Conditions
- Head and Neck Cancer, Dysphagia, Oropharyngeal Dysphagia, Oropharynx Squamous Cell Carcinoma
- Trial name
- NCT05278039
- Testing
- Respiratory-Swallow Phase Training, Swallow Practice
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Northwestern University
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