Clinical trials: Esophageal Dysmotility
Constipation, Diarrhea
Efficacy of a Dietary Supplementation With Lactobacillus Reuteri for Digestive Health in an Elderly Population
The purpose of this study is to investigate the effect of a daily supplement consisting of the probiotic bacteria, Lactobacillus reuteri, on the digestive health among persons 65 years and older.
- Conditions
- Constipation, Diarrhea, Indigestion, Reflux
- Trial name
- NCT01837940
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- Sweden
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Achalasia, Achalasia Cardia
Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy
Peroral endoscopic esophagel myotomy (POEM) is a third space endoscopy technique that depends on creating a submucosal tunnel to expose the esophageal muscle and eventually perform an esophageal myotomy.
- Trial name
- NCT06189859
- Testing
- endoscopic submucosal dissection using SPRAY COAG mode, endoscopic submucosal dissection using Precisect mode
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Gastroesophageal Reflux Disease (GERD), Non-erosive Reflux Disease (NERD)
Assessment of Esophageal Epithelium Integrity With Mucosal Impedance
Gastroesophageal reflux disease (GERD) is a common condition affecting more than 100 million adults in the U.S., and it significantly impacts patients' quality of life while imposing billions of dollars of direct and indirect…
- Trial name
- NCT02318862
- Testing
- Standard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testing
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Gastroesophageal Reflux Disease
Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease
This superiority phase III study to compare the combination of Pantoprazole and Domperidone with Pantoprazole isolated to the treatment of gastroesophageal reflux disease.
- Trial name
- PANDA (NCT01710462)
- Testing
- Pantoprazole + Domperidone, Pantozol®
- Where
- 8 sites in Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
GERD
Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux
Investigation evaluating the effect of coffee on gastro-esophageal reflux disease.
- Trial name
- NCT00584259
- Testing
- Coffee
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, Davis
Gastroesophageal Reflux
Pharmacogenetic Testing in Children With Persistent Gastroesophageal Reflux Disease
This study will use a 22 gene pharmacogenomics panel on 30 children with persistent Gastroesophageal Reflux Disease (GERD) who have not responded to therapy.
- Trial name
- NCT03005080
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
GERD (Gastroesophageal Reflux Disease), NERD
New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)
The goal of this randomized, double-blind, single-center clinical trial RELEIF is to learn if medical devices work to decrease symptoms of gastroesophageal reflux disease (GERD) in adults' patients.
- Conditions
- GERD (Gastroesophageal Reflux Disease), NERD, Heartburn, Regurgitation, Gastric
- Trial name
- RELIEF (NCT07624383)
- Testing
- Esophageal barrier medical device
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Achalasia
redoPOEM : Failure of a First POEM
observational study, measurement of efficacy in the cohort.
- Trial name
- redoPOEM (NCT06044155)
- Where
- 14 sites in France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Bordeaux
Esophageal Motility Disorders, Gastro-esophageal Reflux
Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study
Pressure and flow (PF) analysis allow a detailed report on the bolus passing for each segment of the esophagus. This approach has evidence in oropharyngeal dysphagia, post reflux surgery dysphagia, gastroesophageal reflux in…
- Trial name
- pFlow (NCT03904004)
- Testing
- Peroral endoscopic myotomy, Neumatic dilatation, Botulinum toxin injection
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Miguel Servet
Anesthesia
Risk of Gastric Reflux During Tulip vs GMA(Glottis Mask Airway) Airway
Glottis mask airway (GMA) is supraglottic airway device and is frequently used in patients undergoing general anesthesia. However, gastroesophageal reflux remains a risk during ventilation through supraglottic airway devices.
- Trial name
- TUGGER (NCT06527352)
- Testing
- glottis mask airway, tulip shaped, classical shaped
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Air Force Military Medical University, China
Reflux Disease, Gastro-Esophageal, Vomiting, Postoperative
Antireflux Suture In One Anastomsis Gastric Bypass
To prevent refulx symptoms in a type of bariatric surgery, a suture is taken.there is no enough evidence in support of or against the suture.
- Trial name
- NCT07148492
- Testing
- Antireflux suture, No Antireflux suture
- Where
- Pakistan
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Khyber Teaching Hospital
Dyspepsia
The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.
"Functional dyspepsia" has been defined loosely as "pain or discomfort centered in the upper abdomen." The symptoms can also include fullness, early satiety, bloating, belching, nausea, retching and vomiting.
- Trial name
- NCT00303264
- Testing
- dexloxiglumide, Nexium (esomeprazole)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Forest Laboratories
Esophageal Disease
Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux.
This is a single-center, randomized, open-label clinical study to assess the treatment response of high-dose rabeprazole compared with standard-dose rabeprazole in patients with extra-esophageal manifestations of gastroesophageal…
- Trial name
- NCT04001400
- Testing
- Rabeprazole 20mg bid, Rabeprazole 20mg qd
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Hospital
Eosinophilic Esophagitis
Efficacy and Safety Study of Reslizumab to Treat Eosinophilic Esophagitis in Subjects Aged 5 to 18 Years
This trial will study three doses of reslizumab versus placebo in children with eosinophilic esophagitis (EE). The objectives of the trial will be to study the effectiveness of reslizumab in improving the clinical signs and…
- Trial name
- NCT00538434
- Testing
- Reslizumab, Saline
- Where
- 37 sites in United States, Canada
- Volunteers
- 227 people
- Sponsor
- Ception Therapeutics
GERD
to Assess the Efficacy and Safety of the Probiotic E. Coli Strain M17 on Patients With GERD
The study is an Open Label, Prospective, Non Comparative, Pilot, clinical trial design. Patients with inadequate relief in GI symptoms associated with GERD despite PPI treatment will be screened and those who meet the inclusion…
- Trial name
- NCT00324532
- Testing
- ProBactrix
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- BioBalance Corporation
Achalasia, Gastroesophageal Reflux
ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia
The peroral endoscopic myotomy for the treatment of achalasia is associated with a higher incidence of gastroesophageal reflux disease compared with Heller's myotomy.
- Trial name
- ARAT (NCT04065516)
- Testing
- ARAT technique
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Gastroesophageal Reflux Disease (GERD)
Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Mild to Moderate Erosive Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to investigate the efficacy and safety of Rabeprazole (RAB) Extended-Release (ER) 50 mg versus Esomeprazole (ESO) 40 mg in subjects with erosive gastroesophageal reflux disease (eGERD).
- Trial name
- NCT00658632
- Testing
- Rabeprazole sodium, Esomeprazole
- Where
- 85 sites in United States
- Volunteers
- 1,397 people
- Sponsor
- Eisai Inc.
Gastroesophageal Reflux
Jejunal Feeding Via Gastrojejunal Tube in Refractory Gastroesophageal Reflux
Gastroesophageal reflux disease (GERD) in children can be severe and lead to multiple complications, dizziness, esophagitis, respiratory failure or ENT infections.
- Trial name
- ReJej (NCT05278689)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastroesophageal Reflux Disease
True Short Esophagus in Gastroesophageal Reflux Disease
True short esophagus is controversial in surgery for gastroesophageal reflux disease and hiatus hernia. Recently, it was published that extensive esophageal mobilization achieved an esophageal length adequate to perform around…
- Trial name
- NCT03848494
- Testing
- Surgery
- Volunteers
- 311 people
- Sponsor
- University of Bologna
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