Clinical trials: Esophagectomy
Esophageal Cancer, Postoperative Complications
Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches
Worldwide, esophageal cancer is the 6th most common cause of cancer-related death. Currently curative resection remains the cornerstone of the therapy.
- Conditions
- Esophageal Cancer, Postoperative Complications, Diaphragm, Pulmonary Function
- Trial name
- NCT01053182
- Testing
- Ivor-Lewis Esophagectomy, Sweet Esophagectomy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Sichuan University
Leaks, Anastomotic
Stent Therapy Versus Endoscopic Vacuum Therapy for Anastomotic Leaks After Esophagectomy
Exploratory study of the efficiency of endoscopic stenting versus endoscopic vacuum therapy in patients with intrathoracic esophago-gastric anastomotic leakage after oncological resection of the esophagus.
- Trial name
- EsoLeak (NCT03962244)
- Testing
- EsoSponge, Self-Expanding Metal Stent
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital of Cologne
Esophageal Neoplasm, Laryngeal Neoplasms
Feasibility Study CORPPS
The incidence of cancer in France has increased by +135% to reach nearly 400,000 new cases in 2018. The ten-year cancer control strategy 2021-2030 and the health innovation plan have defined strategic axes.
- Trial name
- FAISA-CORPPS (NCT05406024)
- Testing
- Digital platform
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Esophageal Cancer, Weight Gain
Resection of the Esophagus and Subsequent Weight Loss
The investigators aim to ascertain how food reward signals and eating behaviour relates to the gut-brain pathway in weight-losing patients after curative surgery for oesophageal cancer, and how this pathway responds to clinical…
- Conditions
- Esophageal Cancer, Weight Gain, Eating Behavior, Food Reward
- Trial name
- REWARD (NCT03377660)
- Testing
- Clinical treatment
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Esophagectomy, Pancreaticoduodenectomy
Preoperative Nutritional Support in Esophagectomy or Pancreaticoduodenectomy
We are proposing to evaluate the benefit of preoperative nutritional support with Impact Advanced Recovery in the most vulnerable group of elective gastrointestinal surgery patients who may experience a complication, esophagus…
- Trial name
- NCT00585624
- Testing
- Impact Advanced Recovery, No supplement
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- University of Wisconsin, Madison
Esophageal Cancer, Esophagectomy
Shanghai Clinical Cohort - Esophageal Cancer
A prospective cohort of patients who received esophagectomy for esophageal cancer in participating centers.
- Trial name
- NCT07312526
- Testing
- esophagectomy
- Where
- China
- Volunteers
- 2,116 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Cancer, Recurrent Laryngeal Nerve
The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy
The goal of this clinical trial is to learn whether the application of indocyanine green near-infrared imaging system can accurately locate the recurrent laryngeal nerve (RLN) during lymph node dissection in esophageal cancer…
- Conditions
- Esophageal Cancer, Recurrent Laryngeal Nerve, ICG (Indocyanine Green), Lymph Node Dissection
- Trial name
- NCT07406815
- Testing
- ICG (Indocyanine Green)
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Stricture, Duodenal Stricture
Cryoablation for Benign Gastrointestinal Anastomotic Strictures
Anastomotic stricture is a common complication following foregut surgery. The standard of care for these benign foregut anastomotic strictures is balloon dilatation.
- Conditions
- Esophageal Stricture, Duodenal Stricture, Jejunal Stricture, Anastomotic Stricture of Small Intestine
- Trial name
- NCT04372784
- Testing
- Cryotherapy, Esophagogastroduodenoscopy with Balloon Dilatation
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Southern California
Esophagus Cancer, Carcinoma Esophagus
Supercharged TRAM Evaluation in Cervical Esophagogastroplasty After Esophagectomy
Esophagectomy has high rates of morbidity and mortality, in many cases due to esophagus reconstruction. Anastomotic leakage and fistula are the main esophagectomy complications.
- Trial name
- Supercharged (NCT05954702)
- Testing
- Supercharged TRAM esophagectomy, Conventional Esophagectomy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Esophagectomy, Postoperative Complications
The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy
Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy. Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence.
- Trial name
- NCT00373919
- Testing
- intravenous (IV) administration of erythromycin
- Sponsor
- Kaplan Medical Center
Esophageal Cancer
Comparison of Esophagectomy and Chemoradiation for Patients With cN0-pT1b Stage Esophageal Squamous Cell Carcinoma
The ad-ESD trial is phase III randomized trial to compare adjuvant esophagectomy and chemoradiation for patients with clinical stage N0 and pathological stage T1b squamous cell carcinoma (after endoscopic submucosal dissection).
- Trial name
- NCT04135664
- Testing
- esophagectomy, chemoradiation, active surveillance
- Where
- 6 sites in China
- Volunteers
- 176 people
- Sponsor
- Shanghai Chest Hospital
Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled, Persistent Post Surgical Pain
The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain.
- Trial name
- NCT03095157
- Testing
- fractionated marine lipid concentrate derived from anchovy and sardine oil
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Esophagus Cancer
Rhomboid Intercostal and Subserratum Plane Block for Minimally Invasive Esophagectomy
The objective is to investigate the safety and effectiveness of rhomboid intercostal and subserratum plane (RISS) block for postoperative analgesia after minimally invasive McKeown esophagectomy (MIE-McKeown).
- Trial name
- NCT06092944
- Testing
- Catheterization, Single nerve block, Continuous nerve block
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Luo Fuchao
Esophageal Cancer, Esophageal Neoplasms
TreatmENT of AnastomotiC Leakage After Esophagectomy
Rationale: Anastomotic leakage (0% - 30%) is a severe complication after esophagectomy with mortality rates approximately ranging from 2% - 12%. In addition, it is associated with a prolonged ICU treatment and hospital stay.
- Trial name
- TENTACLE (NCT03829098)
- Testing
- Intervantions for anastomotic leakage after esophagectomy
- Where
- Netherlands
- Volunteers
- 1,509 people
- Sponsor
- Radboud University Medical Center
Esophageal Malignant Neoplasm Primary, Anastomotic Leak
Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak
The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an…
- Trial name
- NCT07449208
- Testing
- Esophagectomy
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Esophageal Neoplasms
Home Jejunostomy Feeding Following Esophagectomy/Gastrectomy
After surgery for oesophageal (gullet) or gastric (stomach) cancer, patients are routinely fed by means of a small feeding tube into the intestine (jejunostomy, JEJ) while they are in hospital.
- Trial name
- NCT01870817
- Testing
- Home jejunostomy feeding
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University Hospitals, Leicester
Esophageal Adenocarcinoma (UICC TNM7), Adenocarcinoma of the Esophagogastric Junction
Perioperative Chemotherapy Compared To Neoadjuvant Chemoradiation in Patients With Adenocarcinoma of the Esophagus
The trial is designed to investigate differences in outcome of patients with esophageal adenocarcinoma and junctional adenocarcinoma treated with perioperative (neoadjuvant + adjuvant) chemotherapy (FLOT) plus surgical resection…
- Trial name
- ESOPEC (NCT02509286)
- Testing
- 5-Fluorouracil, Leucovorin, Oxaliplatin
- Where
- 30 sites in Germany
- Volunteers
- 438 people
- Sponsor
- University Hospital Schleswig-Holstein
Barrett's Esophagus, Esophageal Cancer
Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium
The purpose of this study is to evaluate a cryoablation technique used to ablate human esophageal mucosa.
- Trial name
- NCT01293448
- Testing
- Cryoballoon Ablation
- Where
- 4 sites in United States, Netherlands
- Volunteers
- 21 people
- Sponsor
- Pentax Medical
Anastomotic Leak, Esophageal Cancer
Assessment of Graft Perfusion and Oxygenation for Improved Outcome in Esophageal Cancer Surgery
After the esophagectomy, the stomach is most commonly used to restore continuity of the upper gastro-intestinal tract. The esophagogastric anastomosis is prone to serious complications such as anastomotic leakage (AL) The…
- Trial name
- EDOBS (NCT03587532)
- Testing
- Indocyanine green angiography, Hemodynamic evaluation, Biological and pathological markers of ischemia
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Esophageal Cancer
Does Perioperative Goal Directed Therapy Using Flotrac Improve Outcomes in Esophagectomy Patients
The objective of this prospective, randomized controlled study is to ascertain whether the perioperative use of the FloTrac device to guide fluid and vasopressor management during esophagectomy improves patient outcomes.
- Trial name
- NCT02864355
- Testing
- Goal Directed Therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Medical University of South Carolina