Clinical trials: Esophagectomy
Clinical or Oncologic Benefits of Robot-assisted IVOR-LEWIS in Esophageal Cancer
Robot-assisted IVOR-LEWIS Esophagectomy
Minimally invasive esophagectomy (MIE) have become increasingly popular in esophageal cancer. It is generally accepted that comparing to open resections, MIE results in decreased postoperative pain, faster recovery times, and…
- Trial name
- RAILE (NCT03140189)
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Ruijin Hospital
Esophageal Cancer
The Efficacy of Postoperative Application of HFNC at Acute Phase for Minimally Invasive Esophagectomy Surgery Patients
This is a prospective study that uses the treatment guideline of our chest surgery ICU. Investigators recruited 90 patients who underwent MIE in the National Taiwan University Hospital.
- Trial name
- NCT03816748
- Testing
- High flow nasal cannula, HFNC
- Where
- Taiwan
- Volunteers
- 69 people
- Sponsor
- National Taiwan University Hospital
Esophageal Cancer, Perioperative Analgesia
Perioperative Analgesia Modes in Minimally Invasive Esophagectomy
This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.
- Conditions
- Esophageal Cancer, Perioperative Analgesia, NSAIDs, Opioid
- Trial name
- NCT05504265
- Testing
- Preemptive flurbiprofen axetil, Postoperative flurbiprofen axetil, Patient-controlled analgesia pump
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Esophageal Cancer, Esophageal Carcinoma
Robot-assisted Thoracic Approach Versus Open Transthoracic Esophagectomy .
This is a randomized controlled trial designed to compare robot-assisted thoracic approach with open transthoracic esophagectomy (Ivor Lewis technique) as a surgical treatment for resectable esophageal cancer.
- Conditions
- Esophageal Cancer, Esophageal Carcinoma, Postoperative Complications
- Trial name
- CIR·ROB (NCT04652180)
- Testing
- Esophagectomy
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Hospital Universitari de Bellvitge
Esophageal Cancer
Routine Post-Operative Supplemental Nutrition
Patients undergoing an esophagectomy will be randomized to receive either (1) routine post-operative tube feeding for 1 month post-operative or (2) usual practice, which is tube feeding to continue in the hospital until the…
- Trial name
- NCT02297607
- Testing
- Tube Feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Esophageal Neoplasms
A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer
The purpose of this study is to test 2 different methods of surgery to remove cancer in the esophagus. This research is being done to see whether removing more tissue and lymph nodes surrounding the tumor in the esophagus (known…
- Trial name
- NCT00760604
- Testing
- Esophagectomy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Weill Medical College of Cornell University
Esophagectomy, Postoperative Complications
Infectious Complications After Esophagectomy
Infectious complications represent the most common postoperative adverse events following esophagectomy for cancer, such as pneumonia (15% of cases).
- Conditions
- Esophagectomy, Postoperative Complications, Infections, Pneumonia
- Trial name
- CIFO (NCT06911658)
- Where
- 2 sites in France
- Volunteers
- 1,029 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Esophageal Squamous Cell Carcinoma
Chemoradiation With or Without Nimotuzumab in Treating Esophageal Cancer Patients Who Suffer With Recurrence in Regional Lymph Nodes After Esophagectomy
A randomized phase II tials to study whether it's benefit of adding Nimotuzumab to chemoradiation for patients with esophageal squamous cell carcinoma after radical esophagectomy who suffer with locoregional lymph nodes…
- Trial name
- Nimotuzumab (NCT01402180)
- Testing
- Nimotuzumab, Radiation therapy, chemotherapy
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Fudan University
Esophageal Cancer
Esophagectomy in Middle and Lower Thoracic Esophageal Cancer Patients Through Left Versus Right Transthoracic Approach
Esophageal carcinoma is an aggressive malignant disease with poor prognosis. Surgical resection remains the most effective method for this malignancy.
- Trial name
- NCT02448979
- Testing
- Left thoracotomy, Right thoracotomy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer, Esophageal Carcinoma
Robot-assisted Esophagectomy Versus Conventional Thoracoscopic Esophagectomy
This is the first randomized controlled study to compare the robot-assisted esophagectomy (RAE) to minimally invasive conventional thoracoscopic esophagectomy (CTE).
- Trial name
- RAE vs CTE (NCT03094351)
- Testing
- esophagectomy
- Where
- 6 sites in China
- Volunteers
- 360 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Cancer
Perioperative Management and Outcomes of Minimally Invasive Esophagectomy
The investigators retrospectively reviewed the data of all patients who had undergone esophagectomy and reconstruction in 2015. Patient characteristics, the surgery performed, method of anesthesia, postoperative hospitalization…
- Trial name
- NCT03378869
- Testing
- esophagectomy
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Esophageal Cancer Surgery, Esophagectomy
Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy
The goal of this pragmatic, registry-based, randomized clinical trial is to find out if using botulinum toxin (Botox) to help drain the stomach during an esophagectomy works as well as a pyloromyotomy in patients undergoing…
- Conditions
- Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure, Esophageal Diseases
- Trial name
- EMPTY (NCT06721520)
- Testing
- Botulinum Toxin A (Botox ), Pyloromyotomy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- The Cleveland Clinic
One Lung Ventilation
Comparison of Three Methods of PEEP Titration During One Lung Ventilation in Prone Position
One-lung ventilation and prone positioning during thoracoscopic esophagectomy is associated with pulmonary complications so lung protection is strongly recommended.
- Trial name
- NCT05851612
- Testing
- constant PEEP, Driving pressure guided PEEP, oxygenation method guided PEEP
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Esophageal Squamous Cell Carcinoma
PPIO-005 The Relationship Between Different Nutritional Pathways and Tumor Outcomes After Minimally Invasive Esophagectomy
As there is no consensus to date on the optimal postoperative nutritional support route for patients undergoing minimally invasive esophagectomy, the purpose of this study is to assess whether there is a potential advantage to…
- Trial name
- NCT06192212
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Esophageal Neoplasms, Lymph Node Metastases
Distribution of Lymph Node Metastases in Esophageal Carcinoma
Background: Lymph node status is an important prognostic parameter in esophageal carcinoma and an independent predictor of survival.
- Trial name
- TIGER (NCT03222895)
- Where
- 19 sites in United States, Brazil and 12 more
- Volunteers
- 5,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Esophagectomy, No Signs of Cancer Recurrence
Pylorus Dysfunction After Esophagectomy and Gastric Tube Reconstruction. Effect of Pneumatic Pylorus Dilatation During Hospital Stay, Surgical Complications During in Hospital Stay
Delayed emptying of the gastric tube after esophagectomy is a frequent and durable problem. No treatment is currently available.
- Conditions
- Esophagectomy, No Signs of Cancer Recurrence, Delayed Gastric Emptying
- Trial name
- NCT02086461
- Testing
- Pneumatic pyloric dilatation, 15 mm pyloric balloon dilatation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Esophagectomy, HALP Score
Perioperative HALP and Surgical Outcomes
Esophagectomy is associated with substantial postoperative morbidity despite advances in perioperative care. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score has been proposed as a composite biomarker reflecting…
- Conditions
- Esophagectomy, HALP Score, Perioperative Biomarkers, Postoperative Complications
- Trial name
- NCT07761975
- Testing
- Perioperative HALP Score Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Istanbul Saglik Bilimleri University
Lung Neoplasms, Esophageal Neoplasms
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.
- Conditions
- Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism
- Trial name
- NCT01267305
- Testing
- Fondaparinux, Nadroparin Calcium
- Where
- China
- Volunteers
- 362 people
- Sponsor
- Shanghai Zhongshan Hospital
Acquired Hyperinsulinemic Hypoglycemia
Avexitide Safety and Efficacy to Treat Acquired Hyperinsulinemic Hypoglycemia
The primary goal of this study is to evaluate the safety and efficacy of two different dosing regimens of an investigational drug called Avexitide in treating low blood sugar in patients with Acquired Hyperinsulinemic…
- Trial name
- NCT04652479
- Testing
- Avexitide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Dr. Tracey McLaughlin, MD
Esophageal Cancer
Drainless Robot-assisted Minimally Invasive Esophagectomy
The aim of this study is the evaluation of two different chest drain management strategies in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE) for esophageal cancer with regard to perioperative…
- Trial name
- RESPECT (NCT05553795)
- Testing
- Early removal of chest drain, Chest drain
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Technische Universität Dresden