Clinical trials: Esophagitis
Eosinophilic Esophagitis
Somatization, Anxiety, and Disordered Sleep in Pediatric Eosinophilic Esophagitis
Eosinophilic esophagitis
- Trial name
- NCT04309786
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Diego
Refractory Reflux Esophagitis
Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole
The research aims to investigate whether trimebutine maleate combined with rabeprazole can improve the clinical efficacy in patients With refractory Los Angeles grade A or B reflux esophagitis .
- Trial name
- rRE (NCT02986685)
- Testing
- Trimebutine Maleate, rabeprazole
- Where
- China
- Sponsor
- Xijing Hospital of Digestive Diseases
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Esophagitis
Off Label Use of Infliximab in Adult Patients With Severe Eosinophilic Esophagitis
Eosinophilic Esophagitis (EE) is a chronic inflammatory disorder of the esophagus with a constantly increasing prevalence. It has been demonstrated that the expression of the cytokine TNF-α is up regulated in EE and that this…
- Trial name
- IEE (NCT00523354)
- Testing
- Infliximab
- Where
- Switzerland
- Sponsor
- Swiss EE Study Group
Radiation Esophagitis
Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation
The purpose of the study is to explore options for preventing and reducing symptoms of radiation esophagitis (RE). The researchers will also look what symptoms participants experience, and whether there are differences in weight…
- Trial name
- NCT05659576
- Testing
- Sucralfate, Usual Care, One consent
- Where
- 7 sites in United States
- Volunteers
- 142 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Eosinophilic Esophagitis
Confocal Laser Endomicroscopy in Patients With Eosinophilic Esophagitis
Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution.
- Trial name
- NCT01234376
- Testing
- Confocal laser endomicroscopy
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
GERD
Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM
Peroral Endoscopic Myotomy (POEM) is a well-established treatment for achalasia; however, it is frequently associated with gastroesophageal reflux disease (GERD), with many patients developing LA grade B or higher esophagitis.
- Trial name
- NCT06955520
- Testing
- Vonoprazan, Esomeprazole 40mg
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Asian Institute of Gastroenterology, India
Eosinophilic Esophagitis
Eosinophilic Esophagitis Clinical Therapy Comparison Trial
Eosinophilic Esophagitis (EoE) is a disorder in which a type of white blood cell (eosinophil) involved in allergic reactions, enter and cover the walls of the esophagus (food pipe).
- Trial name
- NCT01821898
- Testing
- Oral Budesonide, Elimination diet
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Baylor College of Medicine
Candidiasis, Esophageal, HIV Infections
A Study of the Side Effects of L-743,872 in Men With Candidal Esophagitis
The purpose of this study is to see if it is safe to give L-743,872 to men with candidal esophagitis, an AIDS-related yeast infection in the esophagus.
- Trial name
- NCT00005921
- Testing
- L-743,872
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Merck Sharp & Dohme LLC
Eosinophilic Esophagitis
San Raffaele EoE Biobank
Eosinophilic Esophagitis (EoE) is a immuno-mediated disease, characterised by a Th-2 food-antigen driven chronic inflammatory response of the esophagus.
- Trial name
- EoEBiobank (NCT05896891)
- Testing
- esophagogastroduodenoscopy (EGD), buccal swab, blood withdrawal
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis
Proof of Concept Study of OC000459 in Eosinophilic Esophagitis
This will be a randomised, double blind, placebo controlled, parallel group evaluation of the effect of OC000459 given orally for eight weeks on active eosinophilic esophagitis.
- Trial name
- NCT01056783
- Testing
- OC000459
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Oxagen Ltd
Gastroesophageal Reflux Disease, Eosinophilic Esophagitis
Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis
The investigators will determine the prevalence of gastroesophageal reflux disease (GERD) in Eosinophilic Esophagitis (EoE) and importantly determine the predictors of response to Proton Pump Inhibitor (PPI) therapy in EoE.
- Conditions
- Gastroesophageal Reflux Disease, Eosinophilic Esophagitis, Dysphagia
- Trial name
- NCT01479231
- Testing
- dexlansoprazole
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis, Diagnoses Disease
Pilot Study of Esocheck in Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a prevalent chronic inflammatory condition of the esophagus characterized by esophageal eosinophilia that can lead to inflammation and stricture formation.
- Trial name
- EoE (NCT04311970)
- Testing
- EsoCheck
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pennsylvania
Esophagitis, Gastro Oesophageal Reflux Disease
Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum
This investigation is designed to evaluate the acid neutralisation action of a new test product versus unmatched placebo.
- Trial name
- NCT05129670
- Testing
- Calcite chewing gum
- Where
- Ireland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Food Allergy, Asthma
Assessing Risk of Food Insecurity Within Households of Children With Food Allergy
Our central hypothesis is that dietary limitations introduced by food allergy will contribute to increased food insecurity in households with food allergic children when compared to food insecure households without food allergic…
- Conditions
- Food Allergy, Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- NCT01897506
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Celiac Disease, Eosinophilic Esophagitis
Improved Diagnostics of Celiac Disease in Children
The main purpose of this study is to improve the diagnostics of celiac disease and reduce the need for invasive endoscopic studies in children.
- Trial name
- NCT02072590
- Where
- 2 sites in Finland, Romania
- Volunteers
- 300 people
- Sponsor
- Tampere University Hospital
Eosinophilic Esophagitis
A Randomized Double Blind Placebo Controlled Study of the Effect of Swallowed Beclomethasone Dipropionate on Inflammatory Markers in Adult Patients With Eosinophilic Esophagitis
The investigators hypothesize that swallowed beclomethasone leads not only to improvement of symptoms and decreased number of eosinophils in esophageal mucosa, but also to a decrease in other markers of tissue inflammation like…
- Trial name
- NCT01016223
- Testing
- Beclomethasone dipropionate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Penn State University
Radiation-induced Esophagitis
Spirulina Derivative for Radiation Esophagitis
To evaluate the efficacy and safety of a Spirulina-derived product in preventing and treating radiation-induced esophagitis in esophageal cancer patients undergoing intensity-modulated radiotherapy (IMRT).
- Trial name
- NCT07324018
- Testing
- Hydrogel of spirulina-derived exosomes., Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Esophagitis, Eosinophilic
The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic antigen-mediated inflammatory disease of the esophagus that affects both children and adults.
- Trial name
- NCT06093204
- Testing
- Dietary evaluation
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
GERD Without Erosive Esophagitis
A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis.
The primary objective is to compare the efficacy between three doses of AZD0865 (25, 50 and 75 mg). The secondary objectives are to compare the efficacy between the three doses of AZD0865 and esomeprazole 20 mg and to evaluate…
- Trial name
- NCT00206284
- Testing
- AZD0865
- Where
- 202 sites in United States, Canada and 8 more
- Volunteers
- 1,400 people
- Sponsor
- AstraZeneca