Clinical trials: Esrd
ESRD
COMEX Study for Dialysis Patients
The goal of the COMprehensive EXercise (COMEX) pilot study is to test feasibility, tolerability and adherence of this novel video-based intra-dialytic chair exercise program for hemodialysis patients over 3 months.
- Trial name
- COMEX (NCT03055299)
- Testing
- COMEX intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
End Stage Renal Disease (ESRD)
HeRO Graft Compared to Permanent Catheters for End Stage Renal Disease (ESRD) Patients Receiving Hemodialysis
The main objective of this research study was to compare the following outcomes between patients with a Hemodialysis Reliable Outflow (HeRO) Graft and patients with a cuffed catheter for dialysis access over one year: quality of…
- Trial name
- NCT01343251
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Merit Medical Systems, Inc.
ESRD, Social Behavior
SOCIABLE Seniors Optimizing Community Integration to Advance Better Living With ESRD
This research is being done to find out the best ways to help people with end stage kidney disease take care of their daily lives and improve their social functioning.
- Conditions
- ESRD, Social Behavior, Physical Disability
- Trial name
- SOCIABLE (NCT03055273)
- Testing
- SOCIABLE
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Thrombosis, Factor XI
A Study to Evaluate the Safety and Pharmacokinetics of BMS-986177 in Participants With End-stage Renal Dysfunction on Chronic Stable Hemodialysis Treatment
An oral dose of BMS-986177 administered in End-stage Renal Dysfunction (ESRD) participants before and after a hemodialysis session to evaluate safety, tolerability, and pharmacokinetics in this patient population.
- Conditions
- Thrombosis, Factor XI, Renal Impairment, ESRD (End-Stage Renal Disease)
- Trial name
- NCT02902679
- Testing
- BMS-986177
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Bristol-Myers Squibb
End Stage Renal Disease, ESRD
Genetic Susceptibility to Cardiovascular Disease in Patients on Kidney Dialysis
This study, done in collaboration with Johns Hopkins University School of Public Health in Baltimore, Maryland, will examine the role of genes in the development of atherosclerotic cardiovascular disease (CVD) in patients…
- Trial name
- NCT00340119
- Where
- United States
- Volunteers
- 871 people
- Sponsor
- National Cancer Institute (NCI)
End Stage Renal Disease (ESRD)
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
This study will identify which regions on the genes, and genes themselves, may account for an increased risk of end stage renal disease (ESRD), that is, near-total loss of kidney function, for people of African American descent.
- Trial name
- NCT00559767
- Where
- United States
- Volunteers
- 2,860 people
- Sponsor
- National Cancer Institute (NCI)
ESRD
Sodium-restricted Diets and Symptoms in End Stage Renal Disease: An RCT
Dietary sodium intake independently increases the risk of mortality in end stage renal disease (ESRD). It plays a significant role in hypertension, hypervolemia, and left ventricular hypertrophy (LVH), and blunts the…
- Trial name
- NCT02778516
- Testing
- Sodium Restriction
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
ESRD
Bringing Care to Patients: Patient-Centered Medical Home for Kidney Disease
This study will implement and evaluate a patient-centered medical home for kidney disease (PCMH-KD) compared to the usual model of dialysis care.
- Trial name
- PCMH-KD (NCT02270515)
- Testing
- Patient-Centered Medical Home for Kidney Disease (PCMH-KD)
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of Illinois Chicago
End Stage Renal Disease (ESRD)
Food Preparation Effects on Gut Bacteria in Patients on Peritoneal Dialysis
This is an intervention study of the effects of food preparation on the gut bacteria in patients with end stage renal disease on peritoneal dialysis.
- Trial name
- NCT02467530
- Testing
- AGE
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
End-stage Renal Disease (ESRD)
A Study of Safety, PK, & PD of ISIS 416858 Administered Subcutaneously to Patients With End-Stage Renal Disease on Hemodialysis
Evaluation of safety, tolerability, PK and PD of ISIS 416858 in patients with end-stage renal disease (ESRD) receiving chronic hemodialysis.
- Trial name
- NCT02553889
- Testing
- ISIS 416858
- Where
- 8 sites in Canada
- Volunteers
- 49 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
ESRD
Impact of Preemptive Living Donor Renal Transplantation on Quality of Life , Occupational Rehabilitation and Societal Participation of Transplant Recipients
Living donor (LD) kidney transplantation is currently the best treatment for end-stage renal disease (ESRD) in terms of life expectancy and quality of life.
- Trial name
- QUAVIREIN_RDDV (NCT02893475)
- Volunteers
- 534 people
- Sponsor
- Central Hospital, Nancy, France
Obesity, ESRD
Bariatric Surgery for ESRD Patients vs Control
This study will address a true clinical problem by developing a risk/benefit analysis for rapid surgical weight loss in the ESRD population.
- Trial name
- NCT00580762
- Testing
- Roux-en-y gastric bypass (RYGB)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
ESRD
Pharmacoepidemiological Study of Secondary Hyperparathyroidism in Lorraine
The pharmacoepidemiological EPHEYL (Étude PHarmacoÉpidémiologique de l'hYperparathyroïdie secondaire en Lorraine) study is a 2-year, open-cohort, prospective, observational study on incident SHPT, i.e.
- Trial name
- EPHEYL (NCT02888639)
- Volunteers
- 305 people
- Sponsor
- Central Hospital, Nancy, France
End Stage Renal Disease (ESRD)
A Safety Study of Tocilizumab to Improve Transplant Rates in Highly Sensitized Patients Awaiting Kidney Transplantation
In this Phase I/II trial, 10 highly sensitized patients will be entered after informed consent and will receive Intravenous Immunoglobulin (IVIG) at 2 gm/kg + Tocilizumab 8 mg/kg x 5 doses on days 15, 45, 75, 105, 119, 135, and…
- Trial name
- NCT01594424
- Testing
- Tocilizumab, Intravenous Immunoglobulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
ESRD
Calcium Mass Balance and Dialytic Efficiency of a New cITRate-containing and Acetate-free Dialysis flUidS: CITRUS Study
This study aimed to evaluate the effect on the calcium balance of a concentrate with 1 mM citrate and locate the equivalent concentration of calcium (Ca_eq) at a concentration of 3 mM acetate and traditional with 1.5 mM calcium…
- Trial name
- CITRUS (NCT02848937)
- Testing
- Bath with citrate, Bath with citrate and Ca_eq
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda Ospedaliera, Ospedale Civile di Legnano
End Stage Renal Disease, Kidney Failure
A Long-Term Safety Extension Trial of Ferric Citrate in Patients With End-Stage Renal Disease (ESRD) on Dialysis
A long-term safety study of ferric citrate (KRX-0502) in renal failure patients who have completed study KRX-0502-304. Only patients who participated in the KRX-0502-304 trial may participate in this trial.
- Conditions
- End Stage Renal Disease, Kidney Failure, Renal Failure, Hyperphosphatemia
- Trial name
- NCT01554982
- Testing
- ferric citrate
- Where
- 34 sites in United States, Puerto Rico
- Volunteers
- 168 people
- Sponsor
- Keryx Biopharmaceuticals
Chronic Kidney Disease (CKD), End-stage Renal Disease (ESRD)
Impact of Vitamin D Therapies on Chronic Kidney Disease
This investigation will consist of a prospective study utilizing two separate populations of patients with 25(OH)D deficiency, one population with chronic kidney disease (CKD) and one with normal renal function.
- Trial name
- NCT01222234
- Testing
- Cholecalciferol - CKD, Calcitriol - CKD, Cholecalciferol - non-CKD
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Kansas Medical Center
End Stage Renal Disease (ESRD)
Substitution of Acetate by Citrate in the Bicarbonate Based Hemodialysis
Acetate is the primary acidifying solution used in bicarbonate-based hemodialysis worldwide. It has been published in small trials or case series that the addition of acetate is associated with a rise in nitric oxide production…
- Trial name
- NCT02745340
- Testing
- Acetate by Citrate substitution and vice versa
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
End Stage Renal Disease (ESRD)
Study of Myfortic in Combination With Tacrolimus and Thymoglobulin in Early Corticosteroid Withdrawal
To determine the safety and efficacy of a new formulation of Myfortic in combination with tacrolimus and thymoglobulin.
- Trial name
- NCT00374803
- Testing
- Mycophenolic Acid (Myfortic)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Cincinnati