Clinical trials: Esrd
Erythropoietin Resistant Anemia (EPO Resistant Anemia)
" Evaluation of Erythropoietin Therapy in Patients With End-Stage Kidney Disease on Regular Hemodialysis: Hemoglobin Outcomes, and Metabolic Syndrome as a Risk Factor for Erythropoietin Resistance "
The primary aim of this study is to investigate the association between metabolic syndrome and erythropoietin resistance in patients with End-Stage Kidney Disease (ESKD).
- Trial name
- NCT06983756
- Testing
- Erythropoietin
- Volunteers
- 66 people
- Sponsor
- Fayoum University
Acute Kidney Failure
Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT
The aim of this study is to measure plasma levels of essential vitamins, trace elements and amino acids in critically ill patients with severe AKI.
- Trial name
- NCT02470520
- Testing
- CRRT
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Kidney Disease Stage 5 on Dialysis
Desidustat in the Treatment of Anemia in CKD on Dialysis Patients
A phase 3, multicenter, open-label, randomized, active-controlled study to evaluate the efficacy and safety of Desidustat Tablet versus Epoetin alfa Injection for the treatment of anemia in patients with CKD on dialysis. (DREAM-D)
- Trial name
- DREAM-D (NCT04215120)
- Testing
- Desidustat Oral Tablet, Epoetin Alfa
- Where
- 7 sites in India
- Volunteers
- 392 people
- Sponsor
- Zydus Lifesciences Limited
Chronic Kidney Disease
Impact of HemoDiaFIltration on Physical Activity and Self- Reported Outcomes
This is a randomized controlled clinical trial that will analyze the impact of high volume online HDF in comparison to high-flux HD on measured physical activity.
- Trial name
- HDFIT (NCT02787161)
- Testing
- Hemodiafiltration, Hemodialysis
- Where
- 13 sites in Brazil
- Volunteers
- 195 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Endothelial Dysfunction, Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs.
- Trial name
- NCT05344573
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
Neutrophil Gelatinase-associated Lipocalin (NGAL) Evaluation in Emergency Department (ED) All-Comers
This study is to evaluate the NGAL point of care device as an aid in the early risk assessment of AKI (acute kidney injury)in an All-Comers ED population.
- Trial name
- NCT00845741
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Abbott RDx Cardiometabolic
Healthy, Chronic Kidney Diseases
A Study of Renal Microvessel Imaging for Chronic Kidney Disease
The purpose of this research is to study the efficacy of ultrasound microvessel imaging for evaluation of Chronic Kidney Disease.
- Trial name
- NCT05764642
- Testing
- Definity, Super-resolution ultrasound imaging
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Covid19, Chronic Kidney Diseases
The REnal Patients COVID-19 VACcination Immune Response (RECOVAC IR) Study
Rationale: COVID-19 is associated with severely increased morbidity and mortality in patients with severely impaired kidney function, on dialysis or alive with a kidney transplant.
- Trial name
- RECOVAC-IR (NCT04741386)
- Testing
- SARS-CoV-2 vaccination
- Where
- 4 sites in Netherlands
- Volunteers
- 854 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Chronic Kidney Failure
Efficacy and Safety Study of Magnesium Iron Hydroxycarbonate for the Reduction of High Blood Phosphate in Hemodialysis Patients
Magnesium iron hydroxycarbonate is a phosphate binder that absorbs phosphate from food, reducing the amount that the body can absorb.
- Trial name
- NCT00317694
- Testing
- Fermagate
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 111 people
- Sponsor
- Ineos Healthcare Limited
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atherosclerosis, Chronic Kidney Disease
Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy
The aim of the study is to value, in patients with chronic kidney disease and hypertension, whether medical therapy plus interventional renal artery revascularization is superior to medical therapy alone for the treatment of…
- Conditions
- Atherosclerosis, Chronic Kidney Disease, Hypertension, Renovascular, Ischemic Nephropathy
- Trial name
- NITER (NCT01023373)
- Testing
- Medical treatment, PTRS, renal artery stent
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Type 2 Diabetes Mellitus (T2DM), Renal Insuficiency
The Pharmacokinetics Study of Fotagliptin in Patients with Different Degrees of Renal Insufficiency
The trial was designed in a single dose, open, non-randomized, multi-dose parallel control group. The study of patients were mild and moderate renal insufficiency, and matched healthy subjects.
- Trial name
- RI (NCT06883656)
- Testing
- SAL067
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Chronic Kidney Diseases
Helping Relationships From Significant Others on Healthy Lifestyle and Quality of Life Among Patients With CKD( CKD Lifestyle)
This clinical trial aims to evaluate the effectiveness of a helping relationships intervention program for patients with chronic kidney disease (CKD).
- Trial name
- CKD lifestyle (NCT02076256)
- Testing
- helping relationships
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
End-Stage Renal Disease, Stroke
Assessing Cognitive fUnction and MEasuring the Cerebral circulatioN on HaemoDialysis
Stroke disease and cognitive impairment are common in patients established on haemodialysis (HD) for end-stage renal disease (ESRD). Further, initiation of HD appears to transiently increase the risk of stroke.
- Conditions
- End-Stage Renal Disease, Stroke, Cognition Disorders
- Trial name
- ACUMEN-HD (NCT02393222)
- Testing
- Observing effect of routine HD
- Volunteers
- 97 people
- Sponsor
- NHS Greater Glasgow and Clyde
Chronic Kidney Disease, Hyperparathyroidism, Secondary
Study to Evaluate Cinacalcet in Children With Chronic Kidney Disease
The primary objective of the study was to evaluate the safety and tolerability of cinacalcet after a single oral dose in children aged 28 days to less than 6 years with chronic kidney disease receiving dialysis.
- Conditions
- Chronic Kidney Disease, Hyperparathyroidism, Secondary, Secondary Hyperparathyroidism
- Trial name
- NCT01290029
- Testing
- Cinacalcet
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 14 people
- Sponsor
- Amgen
Thrombocytopaenia, Impaired Renal Function
Compare Linezolid-Induced Thrombocytopenia in Patients With Normal Renal Function Versus Impaired Renal Function
Linezolid exhibits a broad spectrum of activity against Gram-positive bacteria, including methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci.
- Trial name
- LinezRenal (NCT06761131)
- Testing
- Linezolid (LZD)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Renal Failure Acute Chronic
Bispectral-Electroencephalography (EEG) in First Time Hemodialysis
The severity of minimal dialysis disequilibrium syndrome (DDS) is currently detected and graded clinically using clinical criteria.
- Trial name
- BIS7 (NCT03276273)
- Testing
- recording of Bispectral Index
- Where
- 2 sites in China, Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Septic Shock, Delirium
Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.
- Conditions
- Septic Shock, Delirium, Renal Failure
- Trial name
- NCT01836302
- Testing
- Observation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Manitoba
Renal Impairment
Effect of Renal Impairment on Evobrutinib Pharmacokinetics (PK)
The study will investigate the PK and safety of evobrutinib in subjects with different degree of renal impairment as compared to subjects with normal renal function.
- Trial name
- NCT03436394
- Testing
- Evobrutinib
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
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