Clinical trials: Essential (Primary) Hypertension
Hypertension, Hypercholesterolemia
Efficacy and Safety of Ezetimibe/Rosuvastatin and Amlodipine Patients With High Blood Pressure and High Cholesterol
The goal of this clinical trial is to test whether one pill that combines ezetimibe, rosuvastatin, and amlodipine can safely lower cholesterol and blood pressure in Korean adults with high blood pressure and high cholesterol.
- Trial name
- NCT07564726
- Testing
- Amlodipine, Ezetimibe/Rosuvastatin
- Where
- 21 sites in South Korea
- Volunteers
- 163 people
- Sponsor
- Celltrion Pharm, Inc.
Pediatric Disorder, Pediatric Obesity
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Pediatric primary hypertension is increasingly common, occurring in 5-10% of normal-weight children and up to 25% of children with obesity. It is a risk factor for adult cardiovascular and renal disease.
- Conditions
- Pediatric Disorder, Pediatric Obesity, Primary Hypertension
- Trial name
- PHRAS (NCT03310684)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Essential Hypertension
The Prevalence of Sympathetic Overactivity in Primary Hypertensive Patients.
The purpose of this NIS is to assess the prevalence of sympathetic overactivity in patients with newly diagnosed essential hypertension.
- Trial name
- SORT (NCT01295021)
- Where
- 97 sites in India
- Volunteers
- 1,514 people
- Sponsor
- AstraZeneca
Essential Hypertension
NW Roselle in Grade 1 Essential Hypertension: Phase III Clinical Trial
In this Phase III clinical trial, researchers evaluate the efficacy and safety of NW Roselle®, a powdered medicinal product developed by Natural Wellness.
- Trial name
- NCT06141200
- Testing
- NW Roselle, Captopril 25Mg Tab
- Volunteers
- 286 people
- Sponsor
- Natural Wellness Egypt
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
Prevention, Arterial Hypertension
Possibilities of Perceiving Information on the Primary Prevention of Cardiovascular Diseases in Persons Suffering From Essential Hypertension Through a Social Network
A randomized, prospective study conducted on the basis of a social network (Instagram platform), two-stage. At the first stage, the online school "Save Your Heart" was announced and 945 applicants were enrolled in the training.
- Trial name
- SocialCor (NCT04944472)
- Testing
- HDKQ questionnaire
- Where
- Russia
- Volunteers
- 125 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Hypertension, Endothelial Function
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension
Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and…
- Trial name
- HYPER-endoEV-a (NCT07728630)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Primary Hypertension
A Randomized Patient Preference Trial on Heat-sensitive Moxibustion for Primary Hypertension in Community
Heat-sensitive moxibustion, an important mean of external therapy of traditional Chinese medicine, has unique advantages in treating various chronic diseases than common moxibustion.
- Trial name
- NCT04788563
- Testing
- Heat-sensitive moxibustion plus original antihypertensive treatment (compulsively randomized arm), Original antihypertensive treatment (compulsively randomized arm), Heat-sensitive moxibustion plus antihypertensive treatment (voluntarily randomized arm)
- Where
- 7 sites in China
- Volunteers
- 400 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Essential Hypertension
The Effect of the Use of BATHE Interview Technique on Treatment Compliance in Hypertension Patients in Primary Care
The research is planned to evaluate the treatment compliance after the BATHE interview technique in hypertension patients.
- Trial name
- NCT05476120
- Testing
- BATHE
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Dokuz Eylul University
Hypertension
CKD-828 S-Amlodipine Non-Responder Trial
The aim of present study is to evaluate the efficacy and safety of two dose combination of S-Amlodipine/Telmisartan (2.5/40mg amd 2.5/80mg) compared with S-Amlodipine monotherapy (2.5mg) in hypertensive patients inadequately…
- Trial name
- NCT01501253
- Testing
- CKD-828 2.5/40mg, CKD-828 2.5/80mg, S-Amlodipine 2.5mg
- Where
- South Korea
- Volunteers
- 187 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Hypertension
An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension
The purpose of the study is to evaluate the efficacy and safety of the study drug relative to an active comparator losartan which is in the same class of drug and is approved for use in the pediatric population aged 6 years and…
- Trial name
- NCT02235909
- Testing
- Azilsartan Medoxomil Low-dose, Losartan, Azilsartan Medoxomil Medium-dose (20 mg)
- Where
- 69 sites in United States, Argentina and 10 more
- Volunteers
- 377 people
- Sponsor
- Arbor Pharmaceuticals, Inc.
Primary Hypertension
Multi-Omics to Predict the Blood Pressure Response to Antihypertensives
The goal of this clinical trial is to develop biomarkers composed of multiple OMICs (MOMICs) for prediction of blood pressure response to antihypertensive drugs in the treatment of primary hypertension.
- Trial name
- HT-PREDICT (NCT05917275)
- Testing
- Amlodipine, Olmesartan, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Radboud University Medical Center
Primary Hypertension
The Safety and Efficacy of Carotid Body Modulation Therapy in Hypertensive Patients by External Ultrasonic Micro-bubble
The investigators intend to find a noninvasive method for CB modulation therapy and find a simple and convenient indicator for assessing CB activity.
- Trial name
- NCT06116357
- Testing
- External Ultrasonic Micro-bubble
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jing Huang
Primary Hypertension
Dietary Nitrate and the Oral Microbiome in Children With Primary Hypertension
Children and adolescents with primary hypertension (high blood pressure without an underlying secondary cause) are at increased risk of cardiovascular disease in adulthood.
- Trial name
- NCT07236125
- Testing
- No active intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yelda Kasımoğlu
Essential Hypertension
GRK4 Polymorphisms Blood Pressure Response to Candesartan
The purpose of this study is to investigate the association between GRK4 polymorphisms and essential hypertension in southwestern Han Chinese and test whether these polymorphisms were associated with the changes in blood pressure…
- Trial name
- NCT01629225
- Testing
- Candesartan
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Third Military Medical University
Primary Hypertension
High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS) for Hypertension: A Randomized Controlled Trial
This study focuses on individuals with primary hypertension, with the main objective of investigating the effectiveness and safety of high-intensity transcranial alternating current stimulation (Hi-tACS) as a non-invasive…
- Trial name
- NCT07566650
- Testing
- Active High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypertension
An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age
The purpose of this study is to evaluate in a randomized, double-blind fashion, the long-term safety, tolerability and efficacy profile of aliskiren compared to the active comparator enalapril in children, 6 - 17 years old with…
- Trial name
- NCT01151410
- Testing
- Aliskiren, Enalapril
- Where
- 36 sites in United States, Guatemala and 5 more
- Volunteers
- 208 people
- Sponsor
- Novartis Pharmaceuticals
Primary Hypertension, Hypertension, Resistant to Conventional Therapy
Causal Inference Research of Resistant Hypertension Treatment With Chinese Approach in a Cohort Study
The research of clinical effectiveness assessment is to explore the causal relationship between treatment and outcome.Accordingly, based on the effectiveness of tan-yu treatment, the research takes the Resistant Hypertension (RH)…
- Trial name
- NCT01904695
- Testing
- Herbs, Antihypertensive drugs
- Where
- China
- Volunteers
- 192 people
- Sponsor
- China Academy of Chinese Medical Sciences