Clinical trials: Essential Hypertension.
Primary Hypertension, Secondary Hypertension
HaemoDYNAMICs in Primary and Secondary Hypertension
The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive…
- Conditions
- Primary Hypertension, Secondary Hypertension, Aortic Stenosis, Renal Insufficiency
- Trial name
- DYNAMIC (NCT01742702)
- Testing
- Nitroglycerin 0.25 mg (single dose, no longer given since January 2017), Salbutamol 400 µg (single dose, no longer given since January 2017), L-arginine (10 min infusion, no longer given since January 2017)
- Where
- 2 sites in Finland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tampere University
Essential Hypertension, Endothelial Dysfunction
Evaluation of Black Chokeberry Bio Juice on Blood Pressure Levels and Endothelial Damage
In Romania, the diseases of the circulatory system account for 59.3% of deaths, representing the main cause of morbidity and mortality.
- Conditions
- Essential Hypertension, Endothelial Dysfunction, Inflammation
- Trial name
- AROBLENDO (NCT05912322)
- Testing
- Black chokeberry juice
- Where
- Romania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy "Victor Babes" Timisoara
Essential Hypertension
Fimasartan (BR-A-657) Multiple Oral Dose in Healthy Subjects
The objective of this study is to determine the safety and tolerability and to determine the Pharmacokinetic and Pharmacodynamic(PK/PD) of ascending multiple oral dose of BR-A-657 in healthy male subjects.
- Trial name
- NCT01289899
- Testing
- BR-A-657
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
This study is aimed to evaluate the pharmacokinetics and the drug-drug interaction among anti-hypertension drugs-amlodipine, losartan, and hydrochlorothiazide.
- Trial name
- NCT01198249
- Testing
- multiple dose, crossover study between single and concomitant administrations of amlodipine, losartan, and hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypertension
CKD-828(80/2.5mg) Pharmacokinetic Study
The purpose of this study is to evaluate the pharmacokinetic characteristics of CKD-828(Fixed Dose Combination Tablet; Telmisartan and S-Amlodipine) in healthy volunteer.
- Trial name
- NCT01246193
- Testing
- CKD-828(FDC), Combination Therapy
- Where
- South Korea
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Hypertension,Essential, Exercise Activity
Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure
The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines.
- Trial name
- DIISCCO (NCT04103411)
- Testing
- 24h-Ambulatory Blood Pressure
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Anil Nigam
Pulmonary Hypertension, Metal Poison
Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients
Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls.
- Trial name
- NCT04756076
- Testing
- Metal level measurements
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Jiapeng Huang
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015 and Co-administration of BR1015-1 and BR1015-2 Under Fasting Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015 and co-administration of BR1015-1 and BR1015-2 in healthy volunteers under fasting conditions
- Trial name
- NCT06744127
- Testing
- BR1015, BR1015-1, BR1015-2
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
Prognostic Risk of Patients With Essential Hypertension for Cardiovascular Events (PROSPECT)
The registry study aims to determine serial biomarkers to prognosis of Essential Hypertension
- Trial name
- NCT03708601
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Primary Hypertension
The Safety and Efficacy of Carotid Body Modulation Therapy in Hypertensive Patients by External Ultrasonic Micro-bubble
The investigators intend to find a noninvasive method for CB modulation therapy and find a simple and convenient indicator for assessing CB activity.
- Trial name
- NCT06116357
- Testing
- External Ultrasonic Micro-bubble
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jing Huang
Essential Hypertension
Study to Compare and Assess the Safety and Pharmacokinetic Characteristics After Oral Administration of Fimasartan (BR-A-657∙K) in Healthy Elderly and Young Male Volunteers
The purpose of this study is to compare and assess the safety and pharmacokinetic characteristics after oral administration of fimasartan (BR-A-657∙K) in healthy elderly and young male volunteers.
- Trial name
- Fimasartan (NCT00937534)
- Testing
- Fimasartan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
A Study to Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Fimasartan in Healthy Male Volunteers
The purpose of this study is to evaluate the effect of atorvastatin on the pharmacokinetics of fimasartan.
- Trial name
- NCT00991705
- Testing
- Atorvastatin, Fimasartan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
Study of the Product QGC001 as a Single Dose and Multiple Doses Administered Orally to Healthy Adult Subjects
1QG2 is a Phase 1 study aiming to assess the safety and tolerability of ascending single/multiple oral doses (SAD \& MAD) in healthy young subjects, the preliminary food interaction and the effect of QGC001 on blood pressure and…
- Trial name
- NCT01900184
- Testing
- QGC001 [(3S,3'S)-4,4'-dithiobis (3-aminobutane-1-sulfonic acid)]
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Quantum Genomics SA
Hypertension,Essential
Brain BOLD fMRI in Hypertensive and Normotensive Participants
This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be modulated by blocking the…
- Trial name
- BRAIrdN (NCT03473275)
- Testing
- Cold Pressor test, PinPrick test
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Essential Hypertension
Hybrid Blood Pressure Monitor Validation
Assessment of the accuracy of a Blood Pressure Measuring Device with a digital display-column, NISSEI DM 3000, according to an adaptation of the "European Society of Hypertension International Protocol Revision 2010 for the…
- Trial name
- NISSEI (NCT01120990)
- Testing
- Blood Pressure Measurement
- Where
- Greece
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Athens
Type 2 Diabetes Mellitus, Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1019" and Co-administration of "BR1019-1" and "BR1019-2"
The objective of this clinical study is to evaluate the pharmacokinetics and the safety after administration of "BR1019" and co-administration of "BR1019-1" and "BR1019-2" in healthy volunteers
- Trial name
- NCT06226727
- Testing
- BR1019, BR1019-1, BR1019-2
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
A Study to Evaluate the Safety and Pharmacokinetics After Oral Concurrent Administration of Fimasartan and Hydrochlorothiazide in Healthy Male Volunteers
To evaluate drug-drug interaction between fimasartan and hydrochlorothiazide.
- Trial name
- NCT00923533
- Testing
- Fimasartan, Hydrochlorothiazide
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Aerobic Exercise, Essential Hypertension
Effect of Aerobic Exercise in Patients With Essential Hypertension
The goal of this observational study is to evaluate the effects of a supervised aerobic exercise training program on weight loss, functional capacity, quality of life (QoL), and depression levels in patients with essential…
- Trial name
- NCT05987436
- Testing
- Supervised Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Hypertension,Essential
Study of SGB-3908 in Healthy Subjects and Mildly Hypertensive Subjects
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) effects of SGB-3908 in healthy subjects and mildly hypertensive subjects.
- Trial name
- NCT06501586
- Testing
- SGB-3908
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Suzhou Sanegene Bio Inc.