Clinical trials: Essential Tremor
Essential Tremor
EMBRACE Tremor BiFUS
This is a post-market (Phase IV) randomized, controlled, blinded, multicenter study with the aim to determine the added value of staged bilateral Exablate thalamotomy compared to a group of patients on previous unilateral…
- Trial name
- NCT06974916
- Testing
- Staged bilateral Exablate thalamotomy, Local standard medical treatment after previous Exablate unilateral thalamotomy.
- Where
- 13 sites in Finland, Germany and 5 more
- Volunteers
- 100 people
- Sponsor
- InSightec
Essential Tremor
directSTIM™ Deep Brain Stimulation System Post-Market Clinical Follow-up Study on Essential Tremor
This is a prospective, multi-center, single arm post-market clinical follow-up study. The present study investigates a product authorized on the European market that will be used per its intended use, and all procedures involved…
- Trial name
- NCT05795218
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Aleva Neurotherapeutics SA
Parkinson's Disease, Essential Tremor
RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)
The purpose of this study is to assess the recharge feature of the Activa RC System in patients who are receiving Deep Brain Stimulation (DBS) for Parkinson's Disease (PD), Essential Tremor (ET), or dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- RECHARGE (NCT00998660)
- Testing
- Activa RC
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 100 people
- Sponsor
- MedtronicNeuro
Upper Limb Essential Tremor (UL ET)
Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor
Upper limb essential tremor (UL ET) is a movement disorder characterized by postural and/or kinetic tremor. It can cause difficulty with everyday tasks such as writing, pouring, and eating, and patients also experience associated…
- Trial name
- NCT05216250
- Testing
- BOTOX
- Where
- 40 sites in United States, Canada
- Volunteers
- 174 people
- Sponsor
- AbbVie
Essential Tremor of the Upper Limbs
Botulinum Toxin A to Treat Arm Tremor
The objective of this study is to assess the efficacy and safety of a single, kinematic-analysis-based intramuscular injection of NT 201, compared with placebo, in moderate to marked essential tremor of the upper limb.
- Trial name
- NCT02207946
- Testing
- IncobotulinumtoxinA
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Merz Pharmaceuticals GmbH
Essential Tremor
A Pilot Efficacy and Safety Study of ST101 in Essential Tremor
This study will look at the ability of ST101 to treat symptoms in subjects with Essential Tremor. This study will also examine the safety and tolerability of the drug.
- Trial name
- NCT01332695
- Testing
- ST101
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sonexa Therapeutics, Inc.
Tremor, Essential, Neurologic Manifestations
Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor
The objective of this study is to evaluate the safety and feasibility of Auto Focusing (AF) echo imaging using the ExAblate Neuro system
- Conditions
- Tremor, Essential, Neurologic Manifestations, Tremor
- Trial name
- ET004 (NCT03935581)
- Testing
- ExAblate
- Where
- 2 sites in Canada, South Korea
- Volunteers
- 20 people
- Sponsor
- InSightec
Essential Tremor
Evaluate SAGE-547 in Participants With Essential Tremor
Stage 1 is a double-blind, proof-of-concept study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of SAGE-547 Injection in male and female participants with essential tremor in the upper limb.
- Trial name
- NCT02277106
- Testing
- SAGE-547
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Sage Therapeutics
Essential Tremor
A Pilot Study of the Cala ONE Device for Essential Tremor
Prospective, multi-center, randomized, controlled study designed to evaluate safety and repeatable effectiveness. Subjects will be randomized 2:1:1 to transcutaneous afferent patterned stimulation (TAPS), sham, or 'no…
- Trial name
- EXCITE (NCT03152136)
- Testing
- Cala ONE device
- Where
- 4 sites in United States
- Volunteers
- 62 people
- Sponsor
- Cala Health, Inc.
Tremor, Action Tremor
Deep Brain Stimulation (DBS) for the Suppression of Tremor
The purpose of the proposed study is to demonstrate the safety and efficacy of the ANS Totally Implantable Deep Brain Stimulation System in the VIM nucleus of the thalamus implanted for the treatment of tremor due to essential…
- Conditions
- Tremor, Action Tremor, Essential Tremor, Tremor, Limb
- Trial name
- NCT02087046
- Testing
- ANS Totally Implantable Deep Brain Stimulation System
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- Abbott Medical Devices
Essential Tremor
A Clinical Study to Evaluate CAD-1883 in Essential Tremor
This is an open-label study designed to evaluate the safety, tolerability and efficacy of CAD-1883, a positive allosteric modulator of the SK channel, administered twice daily orally to adult patients with ET.
- Trial name
- NCT03688685
- Testing
- CAD-1883
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cadent Therapeutics
Essential Tremor, Parkinson's Disease
Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool
The objective of this clinical investigation is to characterize the clinical performance of Abbott's Clinician Programmer Electrode Screening Mode tool (InformityTM tool) in programming InfinityTM deep brain stimulation (DBS)…
- Trial name
- EVIDENT (NCT03794661)
- Testing
- Clinician programmer electrode screening mode tool
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Abbott Medical Devices
Essential Tremor, Parkinson Disease
Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson's Tremor
A prospective, open-label, multi-center pilot study designed to evaluate the safety and effectiveness of the Felix system in the relief of upper limb tremors in adults with essential tremor and Parkinson's disease.
- Trial name
- NCT05842434
- Testing
- Felix NeuroAI Wristband
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Fasikl Inc.
Healthy, Epilepsy
Bridging Gaps in the Neuroimaging Puzzle: New Ways to Image Brain Anatomy and Function in Health and Disease Using Electroencephalography and 7 Tesla Magnetic Resonance Imaging
The human brain presents outstanding challenges to science and medicine. Brain function and structure span broad spatial scales (from single neurons to brain-wide networks) as well as temporal scales (from milliseconds to years).
- Conditions
- Healthy, Epilepsy, Psychosis, Essential Tremor
- Trial name
- NCT05769933
- Testing
- Simultaneous EEG-fMRI at 7 Tesla, Structural MRI at 7 Tesla
- Where
- Switzerland
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Developpement
Essential Tremor
GyroGlove Use in Essential Tremor Patients
This is a multi-centre, single-blind, placebo-controlled trial with an open label follow up. After the baseline assessment, all participants will receive the GyroGlove for two weeks during the open label follow up part of the…
- Trial name
- NCT05958030
- Testing
- GyroGlove
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- GyroGear Ltd
Essential Tremor of the Upper Limb
A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm
The purpose of this study is to determine whether a single treatment with NT 201 (botulinum toxin) is superior to placebo (no medicine) for one-sided treatment of essential tremor in the motor-dominant arm (Unilateral Period).
- Trial name
- NCT04766723
- Testing
- NT 201
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 78 people
- Sponsor
- Merz Pharmaceuticals GmbH
Spinal Cord Stimulation, Deep Brain Stimulation
Implantable Systems Performance Registry
The Implantable Systems Performance Registry (ISPR) was developed to evaluate the long-term reliability and performance of market-released Medtronic Neuromodulation infusion and stimulation products.
- Conditions
- Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
- Trial name
- ISPR (NCT00959296)
- Testing
- Various
- Where
- 50 sites in United States, Austria and 5 more
- Volunteers
- 10,981 people
- Sponsor
- MedtronicNeuro
Essential Tremor
T2000 in Essential Tremor - Open Label Continuation
This study will evaluate the safety and efficacy of T2000 when used to treat patients with moderate to severe essential tremor over an 18 month period.
- Trial name
- NCT00655278
- Testing
- T2000
- Where
- 3 sites in Canada
- Volunteers
- 5 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Parkinson Disease, Essential Tremor
24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor
This study investigates the long-term safety and tolerability of home peroneal eTNM® therapy using the URIS I™ device in subjects with Parkinson's disease (PD) or Essential Tremor (ET).
- Trial name
- NCT06570421
- Testing
- Peroneal electrical transcutaneous neuromodulation (peroneal eTNM®)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Stimvia s.r.o.
Tremor, Essential Tremor
ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor
A feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Unilateral Thalamotomy in the Treatment of Tremor
- Trial name
- NCT01932463
- Testing
- ExAblate Transcranial System
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- InSightec