Clinical trials: Estrogen Deficiency
Insulin Resistance
Timing Estrogen After MenoPaUSe
The aim of the current study is to test whether the effect of estrogen on insulin metabolism depends on the timing of treatment relative to when a woman went through menopause.
- Trial name
- TEMPUS (NCT01605071)
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Skin Tear, Estrogen Deficiency
Estrogens Levels and Receptors Status and Skin Tears
Background: Skin tears (ST) or "laceration injuries" or "flap wounds" are injuries that are often found in residents of residential care facilities (RCFs).
- Trial name
- ESKITE (NCT04513405)
- Testing
- Blood sampling, Shave Biopsy
- Where
- Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Menopause Surgical, Estrogen Deficiency
The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause
The overarching aim of this study is to assess the downstream effects of abrupt estrogen deficiency in women undergoing elective bilateral oophorectomy by studying: 1.
- Conditions
- Menopause Surgical, Estrogen Deficiency, Adiposity
- Trial name
- RESUME (NCT03631680)
- Testing
- Bilateral Oophorectomy Surgery
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Contraception, Estrogen Deficiency
Effect of Oestrogen on Musculoskeletal Outcomes
This cross-sectional comparison and prospective cohort design study will investigate differences in calcium metabolism, biochemical markers of bone and reproductive health, musculoskeletal health, and iron status between women…
- Conditions
- Contraception, Estrogen Deficiency, Estrogen Excess
- Trial name
- E2 (NCT05587920)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Army Health Branch, British Army
Obesity
Effects of Estrogen Deficiency on Energy Expenditure
Menopause is associated with weight gain, but the reasons why are not clear. In this study, the investigators will determine if reducing estrogen levels causes a decrease in the ability of the body to produce heat.
- Trial name
- NCT01846728
- Testing
- Estrogen suppression
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Testosterone Deficiency, Estrogen Deficiency
Use of Infrared Photomodulation for Hormonal Balance (Joovvin' for Hormonal Health)
8-week pilot study looking at the impact of Joovv's infrared photo modulation product on male and female hormone levels.
- Trial name
- NCT04245527
- Testing
- Joovv Infrared Light Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ProofPilot
Menopause, Estrogen Deficiency
Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
This study will evaluate changes in blood vessels around the heart (e.g., aorta and carotid arteries) and in the brain with the loss of female sex hormones (e.g., estrogen) during the menopause transition.
- Conditions
- Menopause, Estrogen Deficiency, Women, Aging
- Trial name
- NCT05057546
- Testing
- GnRH antagonist
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause, Estrogen Deficiency
ATENEA Study: Adherence to Creatine-Based Nutritional Supplementation in Estrogen-Depleted Women
This is a prospective, multicenter, observational clinical study conducted under routine clinical practice conditions aimed at describing adherence to a creatine-based nutritional supplement (Creaticare FEM) in estrogen-depleted…
- Trial name
- ATENEA (NCT07580846)
- Where
- 4 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Margan Biotech
Arginine Vasopressin Deficiency, Oxytocin Deficiency
Identifying Oxytocin Deficiency in Adults With Pituitary Disease
This is an open-label, pilot study, to characterize oxytocin response to a single dose of oral Estrogen-progestin in patients with arginine-vasopressin deficiency compared to healthy controls.
- Trial name
- NCT06460948
- Testing
- Norethindrone Acetate-Ethinyl Estradiol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Elizabeth Austen Lawson
Primary Ovarian Insufficiency
Primary Ovarian Insufficiency: Phenotype and Optimal Treatment
This pilot study will observe the progression of newly diagnosed POI patients physical and psychology outcomes after initiating standard of care HRT treatment in comparison to healthy female control participants' physical and…
- Trial name
- NCT03568708
- Testing
- Transdermal Estrogen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bone Diseases
Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men
Objective: To define a reference-population of healthy young men (20-29 years old). To establish reference-intervals for: 1. Total, bioavailable and free serum androgens (testosterone, dihydrotestosterone, androstenedione) and…
- Trial name
- NCT00150163
- Where
- Denmark
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Obesity
Prevention of Obesity in Women Via Estradiol Regulation
The purpose of this study is to evaluate potential mechanisms by which estradiol deficiency accelerates fat gain and abdominal fat accumulation in women.
- Trial name
- POWER (NCT00687739)
- Testing
- leuprolide acetate, Estradiol Transdermal, progressive resistance exercise training
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
As women get older and go through menopause, levels of the female reproductive hormone estradiol decrease to low levels. Also with aging, the functioning of the arteries declines.
- Trial name
- SHAPE2 (NCT02042196)
- Testing
- KUVAN, Cetrotide, Climara
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause Surgical, Estrogen Deficiency
Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause
The overarching aims of this study are to: 1. Characterize the rate of in vivo adipogenesis, and changes in adipose tissue gene and protein expression, in the scABD and scFEM depots of women undergoing surgical menopause (↓E2…
- Conditions
- Menopause Surgical, Estrogen Deficiency, Adiposity, Follicle-Stimulating Hormone Deficiency
- Trial name
- RESUME-2 (NCT03856268)
- Testing
- 'Surgical Menopause' Group, 'Drug-Induced Menopause' Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Estrogen Deficiency, Cardiovascular Disease (CVD)
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women
The purpose of this study is to determine whether young women with functional hypothalamic amenorrhea (premenopausal HypoE) is associated with risk factors for pre-clinical cardiovascular disease (CVD).
- Conditions
- Estrogen Deficiency, Cardiovascular Disease (CVD), Functional Hypothalamic Amenorrhea, Endothelial Dysfunction
- Trial name
- NCT03018366
- Testing
- 17beta Estradiol, Progesterone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Iron-deficiency, Inflammation
Iron and Muscular Damage: FEmale Metabolism and Menstrual Cycle During Exercise
This project is an observational controlled randomized counterbalance study. One hundred and three physically active and healthy women were selected to participate in the IronFEMME Study, of which 57 were eumenorrheic, 30 were…
- Conditions
- Iron-deficiency, Inflammation, Exercise Induced Iron-deficiency, Exercise Induced Muscle Damage
- Trial name
- IronFEMME (NCT04458662)
- Testing
- Interval running protocol / eccentric-based resistance exercise protocol
- Where
- Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid