Clinical trials: Estrogen Replacement Therapy
Estrogen Replacement Therapy
Study Comparing Bioavailability of 3 New Formulations of Premarin/MPA With Premarin/MPA (PREMPRO) Reference Formulation
This study will compare the bioavailabity of three new investigational combination formulations of Premarin and medroxyprogesterone acetate (MPA) with a currently marketed formulation of Premarin and MPA, Prempro™.
- Trial name
- NCT00401219
- Testing
- conjugated estrogens/progestin (MPA)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Arthralgia, Menopause
The MUSE Study for Menopausal Arthralgia
The investigators plan to conduct a pilot 4-arm, randomized study comprising the following interventions: muscle strengthening exercises (MSE) alone, estrogen therapy (ET) alone, and a combination of MSE and ET, compared to usual…
- Conditions
- Arthralgia, Menopause, Perimenopausal Disorder, Joint Pain
- Trial name
- MUSE (NCT06530459)
- Testing
- Menopausal hormone therapy, Exercise training, Menopausal hormone therapy + exercise training
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Healthy, Estrogen Replacement Therapy
Beneficial Effects of Oral Premarin Estrogen Replacement Therapy Assessed by Human Genome Array
The purpose of this study is to assess the immunological status of patients using Premarin. Premarin use is associated with an enhanced immune status, and possibly even some anti-cancer effect.
- Trial name
- NCT00318318
- Testing
- Premarin
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Turner Syndrome, Hypogonadism; Ovarian
Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome
This 5-week, phase IV randomized crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06544473
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Postmenopause
Use of the Synthetic Hormone CDB-2914 in Treating Symptoms of Menopause
This study will examine the safety and effectiveness of a synthetic hormone, CDB-2914, for treating symptoms of menopause. It will compare the effects of estrogen and CDB-2914 with those of estrogen and progesterone in…
- Trial name
- NCT00009659
- Testing
- CDB 2914
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Heart Disease
The Estrogen Replacement and Atherosclerosis Trial ; Primary Outcome Measure is Mean Minimal Coronary Artery Diameter After Avg of 3.2 Yrs.
Background: Heart disease is a major cause of illness and death in women. To understand better the role of estrogen in the treatment and prevention of heart disease, more information is needed about its effects on coronary…
- Trial name
- ERA (NCT03097120)
- Testing
- 0.625 mg of conjugated equine estrogen, 0.625 mg of conjugated equine estrogen plus 2.5 mg of medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Wake Forest University Health Sciences
Atherosclerosis
ELITE: Early Versus Late Intervention Trial With Estradiol
The purpose of this study is to examine the effects of oral 17B-estradiol (estrogen) on the progression of early (subclinical) atherosclerosis and cognitive decline in healthy postmenopausal women.
- Trial name
- NCT00114517
- Testing
- 17B-estradiol
- Where
- United States
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alzheimer Disease
Alzheimer's Disease: Therapeutic Potential of Estrogen
This is a 15-month study to determine the effectiveness of hormone replacement therapy in improving memory and the ability to live independently in postmenopausal women with Alzheimer's disease.
- Trial name
- NCT00066157
- Testing
- Transdermal estradiol, Medroxyprogesterone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Wisconsin, Madison
Fibromyalgia
Estrogens Effect on Pain in Postmenopausal Women Suffering of Fibromyalgia
In order to evaluate the potential effects of estrogen treatment in postmenopausal women with fibromyalgia, the investigators used quantitative sensory tests before and after eight weeks of estrogen treatment as compared with…
- Trial name
- NCT01087593
- Testing
- 17β-estradiol
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Ostergotland County Council, Sweden
Menopause, Depression, Anxiety
Affect of Duavive on Mood & Anxiety Symptoms
This study evaluates the impact of conjugated estrogens/ bazedoxifene (CE/ BZA) on the mood (depression and anxiety) in peri- and early menopausal women.
- Conditions
- Menopause, Depression, Anxiety, Sleep, Menopause Related Conditions
- Trial name
- DOMA (NCT04478305)
- Testing
- Duavive 0.45Mg-20Mg Tablet
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Hot Flashes
Gabapentin Versus Estrogen for the Treatment of Hot Flashes
To compare the efficacy and safety of gabapentin, estrogen and placebo in the treatment of hot flashes and other climacteric symptoms.
- Trial name
- NCT00276081
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Postmenopause, Aging
Postmenopausal Women Estrogen and Progesterone Infusion
The purpose of the study is to study the effects of aging, estrogen and progesterone on the brain. Specifically, we want to look at how the hypothalamus and pituitary (two small glands in the brain) respond to estrogen.
- Trial name
- NCT00455741
- Testing
- Estradiol infusion, Progesterone infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Coronary Heart Disease
Heart and Estrogen-Progestin Replacement Study (HERS)
The purpose of the study is to determine whether hormone replacement therapy in post menopausal women with coronary artery disease prevents future heart attacks or death from coronary heart disease.
- Trial name
- NCT00319566
- Testing
- Premarin .625 mg daily plus medroxyprogesterone 2.5 mg daily
- Where
- United States
- Volunteers
- 2,430 people
- Sponsor
- University of California, San Francisco
Depressive Disorder, Mood Disorder
Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)
Often women are prescribed hormone replacement therapy (HRT) during the perimenopause or menopause. Hormone replacement therapy includes both estrogen and progesterone.
- Conditions
- Depressive Disorder, Mood Disorder, Psychomotor Agitation
- Trial name
- NCT00001770
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Postmenopausal Period, Osteoporosis, Postmenopausal
Angeliq Regulatory Post Marketing Surveillance
Angeliq regulatory Post-Marketing Surveillance (PMS) is to get data about safety and efficacy in real practice for the indication approved by Korea Food and Drug Administration (KFDA).
- Trial name
- Angeliq rPMS (NCT01064453)
- Testing
- E2/DRSP (Angeliq, BAY86-4891)
- Where
- South Korea
- Volunteers
- 4,078 people
- Sponsor
- Bayer
Menopause
A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women
This study compares the effects of 12 weeks of treatment with transdermal versus oral estrogen therapy on testsoterone levels and thyroid tests in healthy, naturally menopausal women.
- Trial name
- NCT00224094
- Testing
- Premarin® (oral) vs. Alora® (transdermal)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Watson Pharmaceuticals
Anorexia Nervosa
Estrogen Replacement in Anorexia Nervosa
The present study is a placebo-controlled randomised study on the effects of estrogen replacement upon AN-associated psychopathology, several neurocognitive domains and appetite-regulating circuits in female patients with AN.
- Trial name
- HOSAN (NCT03172533)
- Testing
- ethinyl estradiol 0.03mg and dienogest 2 mg (combination)
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Perimenopause, Menopause
Perimenopausal Estrogen Replacement Therapy Study
Study Background and Objectives: In the U.S. the majority of heart disease deaths are in women, not men. Much of the gender disparity in CVD rates relate to the burden of CV risk in women after the menopause.
- Conditions
- Perimenopause, Menopause, Depression
- Trial name
- PERT (NCT01308814)
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Perimenopausal Depression, Post Menopausal
The Effects of Estrogen Withdrawal on Mood Symptoms in Women
This study evaluates the effects on mood when stopping estrogen replacement therapy. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression.
- Conditions
- Perimenopausal Depression, Post Menopausal, Healthy, Depression
- Trial name
- NCT00060736
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Hot Flushes, Menopause, Postmenopause
Comparison of Estrogen and Methyltestosterone Combination Treatments for Postmenopausal Hot Flushes
This is a research study to evaluate the effectiveness, safety and side effects of several dose levels of esterified estrogens (EE) and methyltestosterone (MT) given individually and in combination compared to a placebo (a tablet…
- Trial name
- NCT00160342
- Testing
- Esterified Estrogens (EE) and Methyltestosterone (MT)
- Where
- 125 sites in United States, Canada and 1 more
- Volunteers
- 1,251 people
- Sponsor
- Solvay Pharmaceuticals