Clinical trials: Etiology
Erectile Dysfunction
Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction
To find out more information on how effective and safe vardenafil is at treating impotence in men living in Russia.
- Trial name
- NCT00657644
- Testing
- Levitra (Vardenafil, BAY38-9456)
- Where
- 8 sites in Russia
- Volunteers
- 130 people
- Sponsor
- Bayer
Lung Abscess
Biomarkers for Diagnosis of Lung Nodules
A need exists for non-invasive testing to aid in clinical decision-making for Computerized Tomography (CT) scan detected lung nodules of indeterminate etiology.
- Trial name
- Nodule (NCT01085864)
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- University of Colorado, Denver
Breast Implantation
Retrospective Study of Incidence and Etiology of Reoperation After Primary Augmentation With Natrelle® Breast Implants
Retrospective multi-center, post-marketing study to evaluate the incidence and etiology of reoperations with Allergan Natrelle® Breast Implants in primary augmentation (RANBI)
- Trial name
- RANBI (NCT02132572)
- Testing
- BIOCELL™ Textured 410 Implant
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 201 people
- Sponsor
- Allergan
Airway Inflammation
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate.
- Trial name
- NCT00814281
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Hypercholesterolemia, Atherosclerosis
Causes and Natural History of Dyslipidemias
This study will evaluate people with dyslipidemias - disorders that affect the fat content in the blood. Fats, or lipids, such as cholesterol and triglycerides, are carried in the blood in particles called lipoproteins.
- Trial name
- NCT00353782
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Undiagnosed Diseases, Cardiovascular Disease
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
Background: Studies show that rare genetic variants might lead to diseases. Researchers want to collect blood and tissue samples so they can study them and better understand diseases.
- Trial name
- NCT02543996
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carbapenem-Resistant Enterobacteriaceae Infection
Microbiological and Clinical Characteristics of Severe Infections Caused by Carbapenem-Resistant Enterobacterales
Severe infections caused by carbapenem-resistant Enterobacterales (CRE) represent a challenge for the clinicians, considering the high mortality rate of these infections.
- Trial name
- MICE (NCT07160569)
- Testing
- Whole Genome Sequencing (WGS), Sequence Type Analysis (ST)
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Out-Of-Hospital Cardiac Arrest
Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest
The goal of this observational study is to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients.
- Trial name
- NCT06122337
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Subcortical Vascular Dementia, Cerebral Small Vessel Diseases
The Efficacy of DL-NBP in Patients With Mild Subcortical Ischemic Vascular Dementia
This is a 48-week, double-blind, randomized, placebo-controlled study. Sixty-four patients are randomly assigned to take NBP (600mg per day) or placebo for 48 weeks, with 32 patients in each treatment group.
- Trial name
- NCT03906123
- Testing
- NBP
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Tianjin Medical University General Hospital
End-stage Renal Disease, Cardiovascular Disease
Effect of Increased Convective Clearance by On-Line Hemodiafiltration on All Cause Mortality in Chronic Hemodialysis Patients
The purpose of this study is to compare the effect of low flux hemodialysis with online hemodiafiltration on all cause mortality and a combination of cardiovascular morbidity and mortality in chronic hemodialysis patients.
- Trial name
- CONTRAST (NCT00205556)
- Testing
- on-line hemodiafiltration, low flux hemodialysis
- Where
- 29 sites in Canada, Netherlands and 1 more
- Volunteers
- 715 people
- Sponsor
- Amsterdam UMC, location VUmc
Covid19, Acute Respiratory Distress Syndrome
The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause
This is a pilot, multi-centre, open-label randomised controlled study to assess the early efficacy of intravenous (IV) administration of CYP-001 in adults admitted to an intensive care unit (ICU) with respiratory failure
- Trial name
- MEND (NCT04537351)
- Testing
- CYP-001
- Where
- 5 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Cynata Therapeutics Limited
PIEZO2-Deficiency Syndrome
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene
Background: PIEZO2 Deficiency Syndrome (PDS) is a genetic disorder that affects a person s ability to feel touches and pain. Researchers want to know more about how PDS changes nerve function.
- Trial name
- NCT06052631
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Non-Hodgkin Lymphoma
A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae
Patients with mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexae (MLOA) will be eligible for treatment with doxycycline (part A: clinico-pathological study); patients with other types of ocular lymphoma…
- Trial name
- IELSG27 (NCT01010295)
- Testing
- doxycycline (tetracycline)
- Where
- 6 sites in Chile, Italy and 2 more
- Volunteers
- 54 people
- Sponsor
- International Extranodal Lymphoma Study Group (IELSG)
Stargardt Disease, Stargardt Macular Degeneration
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)
This Phase 1/2 study will evaluate the safety, tolerability, and preliminary efficacy of subretinal SB-007 administration to determine dose selection in subjects with Stargardt's Type 1 (STGD1).
- Conditions
- Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy
- Trial name
- ASTRA (NCT06942572)
- Testing
- SB-007
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Splice Bio
Reperfusion Injury, Post Cardiac Arrest Brain Injury
Light Utilization COX-Inhibitory Device Therapy for Infant Cardiac Arrest (LUTICA Study). The LUCID Device is Used in the Treatment of Ischemic Brain Reperfusion Injury Caused by Cardiac Arrest in Pediatric Patients.
Approximately 15,200 children receive cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest (IHCA) each year in the United States. Of these, about 60% are less than one year of age.
- Trial name
- LUTICA (NCT07556939)
- Testing
- LUTICIA - Light Utilization COX-Inhibitory Device)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mitovation, Inc
Urinary Tract Infections, Bacteremia
Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs
To evaluate if the combination of pivmecillinam and clavulanic acid (PAC) is non-inferior to ciprofloxacin, trimethoprim-sulfamethoxazole or ertapenem as step down oral therapy in patients with febrile UTI caused by extended…
- Conditions
- Urinary Tract Infections, Bacteremia, Antibiotic Resistant Infection
- Trial name
- PACUTI (NCT05224401)
- Testing
- Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility
- Where
- 5 sites in Sweden
- Volunteers
- 330 people
- Sponsor
- Lund University
Periodontitis, Vascular Disease
Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular…
- Trial name
- NCT01358630
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Hypotension
Dynamic Arterial Elastance to Predict Postural Change Induced Hypotension
During general anesthesia, hypotension might occur during positional change. It is reported that hypotension after positional change from supine to prone is mainly caused by the decrease in preload.
- Trial name
- NCT04850092
- Testing
- Positional change from supine to prone
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Kangbuk Samsung Hospital
Traumatic Brain Hemorrhage, Traumatic Brain Injury
3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hemorrhages
The primary objective of this study is to assess the safety of the 3D Transcranial Ultrasound Brain Imaging (3D TRUBI) device in Traumatic Brain Injury (TBI) patients with intracranial hemorrhage (ICH).
- Conditions
- Traumatic Brain Hemorrhage, Traumatic Brain Injury, Intracranial Hemorrhages, Ultrasound Exams
- Trial name
- 3D-TRUBI (NCT06780436)
- Testing
- 3D Transcranial Ultrasound Brain Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Geneva Foundation
Fibrosis, Radiation Injuries
Trial of Pentoxifylline in Patients With Functional Disability Caused by Radiation-Induced Advanced Regional Fibrosis
After initial assessment of their condition by specified clinical and laboratory parameters, each of the patients will be treated for 8 weeks at the standard pentoxifylline dose (400 mg po TID).
- Trial name
- NCT00001437
- Testing
- pentoxifylline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.