Clinical trials: Etiology
Breast Cancer, Chemotherapeutic Agent Toxicity
L-Carnitine L-Tartrate in Preventing Peripheral Neuropathy Caused By Chemotherapy in Women With Metastatic Breast Cancer
RATIONALE: L-carnitine L-tartrate may prevent peripheral neuropathy caused by chemotherapy. PURPOSE: This randomized clinical trial is studying how well L-carnitine L-tartrate works in preventing peripheral neuropathy caused by…
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Neurotoxicity
- Trial name
- NCT00754767
- Testing
- L-carnitine L-tartrate
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- HealthPartners Institute
Late Onset Epilepsy, Alzheimer Disease
Discard the Curative Causes of Late Onset Epilepsy: the Role of Brain 18F-FDG PET
Etiology and cognitive prognosis in late onset epilepsy differ from young adults epilepsy. At the epilepsy onset, this is crucial to detect potential curative/treatable brain disorders.
- Trial name
- EPITEP (NCT05831371)
- Testing
- TEP FDG
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Central Hospital, Nancy, France
Pneumonia
5 Years Mortality-rate in Patients Treated for Severe Pneumonia in an ICU - a Retrospective Study
Severe pneumonia has a high in-hospital mortality. There are few studies which investigate the long-term mortality in patients that are discharged alive from the hospital.
- Trial name
- pneumonia (NCT02212093)
- Where
- Norway
- Volunteers
- 236 people
- Sponsor
- University Hospital, Akershus
Dilated Cardiomyopathy
Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy
The purpose of this study is to determine the safety and clinical effectiveness of umbilical cord mesenchymal cells transplanted by intravenous infusion in patients with heart failure.
- Trial name
- RIMECARD (NCT01739777)
- Testing
- ucMSC, Controls
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
NTM Lung Infection Due to MAC
Open-label Safety Extension Study Assessing Safety and Tolerability of LAI in Patients Who Participated in Study INS-212
This is an open-label safety extension study to assess the safety and tolerability of once daily dosing of 590 mg Liposomal Amikacin for Inhalation (LAI) added to a multi-drug regimen in participants with nontuberculous…
- Trial name
- NCT02628600
- Testing
- LAI 590 mg, Multi-drug regimen
- Volunteers
- 163 people
- Sponsor
- Insmed Incorporated
Developmental and Epileptic Encephalopathy
Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data
Developmental and Epileptic Encephalopathy (DEE) are a heterogeneous group of neurodevelopmental disorders linked to both epilepsy and its underlying etiology, independently of epileptiform activity.
- Trial name
- DEE-RETRO (NCT06380192)
- Where
- 23 sites in France
- Volunteers
- 400 people
- Sponsor
- Imagine Institute
Brain Aging, Obesity
CARDIA Brain MRI Substudy
Background: The Coronary Artery Risk Development in Young Adults (CARDIA) study is an investigation of cardiovascular risk factors among African-American and white young adults between 18 and 30 years of age, first recruited in…
- Conditions
- Brain Aging, Obesity, Diabetes
- Trial name
- NCT01273311
- Where
- United States
- Volunteers
- 719 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Childhood-Onset Neurodegeneration With Brain Atrophy (CONDBA)
Personalized Antisense Oligonucleotide for A Single Participant With UBTF Gene Mutation
This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with Childhood-Onset Neurodegeneration with Brain Atrophy (CONDBA) due to a heterozygous missense…
- Trial name
- NCT07588581
- Testing
- nL-UBTF-001
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- n-Lorem Foundation
Asthma
Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents
This is a multi-center, double-blind, placebo-controlled, randomized trial of dupilumab adjunctive therapy for prevention of asthma exacerbations in urban children and adolescents with T2-high exacerbation-prone asthma.
- Trial name
- PANDA (NCT05347771)
- Testing
- Dupilumab
- Where
- 8 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Myocardial Infarction
FINGER; Finland-Germany Myocardial Infarction Study
The purpose of this observational study is to find characteristics and risk stratification methods for identification of subjects who have increased risk of death, especially sudden cardiac death, after acute myocardial…
- Trial name
- FINGER (NCT00828698)
- Testing
- No intervention
- Where
- 2 sites in Finland, Germany
- Sponsor
- University of Oulu
Micturition Disorder
Prevalence, Etiology and Therapy of Micturition Disorders of Children With a Mental and/or Motoric Disability
Investigation of the prevalence etiology and therapy of micturition disorders of children with a mental and/or motoric disability
- Trial name
- NCT00148005
- Testing
- Questionnaire and micturition and drinking diaries, Clinical and functional examination (uroflowmetry, bladder scan and video-urodynamic examination), Adaptation of the drinking scheme
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Ghent
Infection
Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter
RATIONALE: Giving the antibiotic teicoplanin by infusion and allowing bacteria to be exposed to the antibiotic for a longer period of time may be effective in preventing or controlling septicemia.
- Trial name
- NCT00024453
- Testing
- teicoplanin
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 1,360 people
- Sponsor
- Children's Cancer and Leukaemia Group
Eustachian Tube Dysfunction, Chronic Otitis Media
Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults
This research study measures how well the Eustachian tube works and looks directly at the anatomy of the Eustachian tube in adults who have had tympanostomy tubes surgically inserted into their eardrums because they have been…
- Trial name
- NCT01251432
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Sepsis, Gram-Positive Bacteremia
CRP and PCT as Predictors of Sepsis Cause
The aim of this retrospective study is to determine the predictive role of serum level of procalcitonin (PCT) and c-reactive protein (CRP) in determining the causative agent of sepsis in surgical intensive care unit (ICU)…
- Conditions
- Sepsis, Gram-Positive Bacteremia, Gram-negative Bacteremia
- Trial name
- NCT05605275
- Testing
- PCT levels, CRP levels, White blood cell count
- Where
- Croatia
- Volunteers
- 81 people
- Sponsor
- Osijek University Hospital
Abuse, Sexual, Abuse, Workplace
Discrimination Harassment of Pain Staff Caused by Patient
Chronic pain is associated with mental disorders, and some patients have behavioral issues. Some patients may sexually or racially harass pain clinic staff.
- Trial name
- NCT05945719
- Testing
- Behavioral therapy
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Pregnancy
Effectiveness of 10% Lidocaine on Relieving Pain Caused by Intravenous Intubation
The goal of this clinical trial is to learn if 10% Lidocaine spray can reduce local pain caused by intravenous (IV) intubation among women.
- Trial name
- NCT07212192
- Testing
- Lidocain spray, Sterilized saline solution
- Where
- Vietnam
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Phenikaa University
Early Repolarization Syndrome
Early Repolarization Syndrome: Define the Risk, Stratify the Coverage and Understand the Causes - Clinical and Genetic Study
The research project aims to try to answer the many questions raised by the identification of new early repolarization syndrome.
- Trial name
- NCT02847039
- Testing
- Blood samples
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
Tobacco, Tobacco Abstinence
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH).
- Conditions
- Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence
- Trial name
- QMH (NCT06883097)
- Testing
- Learn to Quit-HIV (LTQ-H) App, QuitStart
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Wake Forest University Health Sciences
Pleural Mesothelioma
From Presentation to Diagnosis: Patterns of Pleural Effusion
Pleural effusion is a common clinical condition characterized by the accumulation of excess fluid within the pleural space due to disruption of normal pleural fluid dynamics.
- Trial name
- NCT07449624
- Testing
- Pleural effusion pathology
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Mansoura University Hospital
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
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