Clinical trials: Etiology
Pain, Block
REBOUND PAIN AFTER PERIPHERAL NERVE BLOCKS
In recent years, the use of regional anesthesia techniques as part of multimodal analgesia strategies to maximize pain control in patients has reduced opioid requirements and promoted early mobility and rehabilitation in the…
- Trial name
- NCT05635383
- Testing
- PERIPHERAL NERVE BLOCK
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 386 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Venous Thrombosis
Tourniquet Study: A Clinical Trial Into the Effect of Tourniquet Use on the Coagulation System
Knee arthroscopy is the most commonly performed orthopaedic procedure worldwide, with, according to the American Society for Sports Medicine, over 4 million procedures performed each year.
- Trial name
- NCT02567903
- Testing
- Thigh Tourniquet, Knee arthroscopy
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Groene Hart Ziekenhuis
Acute Hypoxemic Respiratory Failure
Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions
Background: There are no proven therapies specific for pulmonary dysfunction in patients with acute hypoxemic respiratory failure (AHRF) caused by infections (including Covid-19).
- Trial name
- DEXA-REFINE (NCT04545242)
- Testing
- Dexamethasone
- Where
- 40 sites in Spain
- Volunteers
- 980 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Stargardt
The Safety and Efficacy of ZVS106e in the Treatment of IRDs Caused by Biallelic Mutations in ABCA4
To evaluate the preliminary safety of monocular and single subretinal injection of ZVS106e injection in the treatment of patients with hereditary retinal degeneration (ABCA4-IRDS) caused by ABCA4 biallelic mutations.
- Trial name
- ZVS106e (NCT07241169)
- Testing
- ZVS106e
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Chronic Heart Failure, Type 2 Diabetes
Prognostic Impact of Diabetes and Weight Variability in Telemonitored Heart Failure
This observational cohort study evaluates the prognostic impact of diabetes, comorbidity burden, and short-term weight variability among adults with chronic heart failure enrolled in a nationwide remote patient monitoring program…
- Conditions
- Chronic Heart Failure, Type 2 Diabetes, Diabetes (DM)
- Trial name
- DM-HF-Tele (NCT07561866)
- Testing
- Diabetes Status, Comorbidity Burden, Weight variability
- Where
- France
- Volunteers
- 16,556 people
- Sponsor
- Satelia
Cardiovascular Mortality, Cardiac Function
Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden
The dietary supplements selenium and Q10 has been evaluated in a double blind placebo-controlled study in an elderly Swedish population.
- Trial name
- KiSel-10 (NCT01443780)
- Testing
- Selenium and ubiquinon (Q10) combined
- Where
- Sweden
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Tricuspid Regurgitation
Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)
This study is a multicenter cohort study including patients diagnosed with tricuspid regurgitation during hospitalization. The primary outcome of the study is all-cause death, and the secondary outcome is cardiovascular events.
- Trial name
- NCT06926959
- Where
- 7 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Non-valvular Atrial Fibrillation
Study Aims to Collect Information in Routine Clinical Practice in Italy About the Number of Patients Suffering From Irregularly Heart Beats Which Are Not Caused by a Heart Valve Problem (Non-valvular Atrial Fibrillation, NVAF) Who Stopped or Changed Rivaroxaban Treatment
While it is well known that stopping or changing medication with blood thinners in patients who suffer from non-valvular atrial fibrillation (NVAF) increases the risk of ischemic stroke (a condition which occurs when a vessel…
- Trial name
- RITMUS-AF (NCT04174859)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Italy
- Volunteers
- 812 people
- Sponsor
- Bayer
Hypercalcemia
Search for New Genetic Causes of Hypercalcemia by Massively Parallel Sequencing of a Genes Panel
Hypercalcemia, whether chronic or acute, exposes the patient to potentially serious complications (arrhythmias, nephrolithiasis, nephrocalcinosis, ...).
- Trial name
- HyCaGene (NCT02908542)
- Testing
- genetic analysis with massively parallel sequencing
- Where
- France
- Volunteers
- 185 people
- Sponsor
- University Hospital, Caen
Oral Lichen Planus
Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus
Introduction :Oral lichen planus (OLP) is one of the most common disorders of the oral cavity which is basically a chronic and inflammated mucocutaneous .There is no cure for OLP currently.
- Trial name
- NCT02453503
- Testing
- Licorice, Triamcinolone Acetonide
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Intracerebral Hemorrhage
Etiology and Prognostic Risk Factors of Intracerebral Hemorrhage in Beijing
There were lack of data and analysis about medical management, etiology, and long-term outcome of Intracerebral Hemorrhage (ICH) in Beijing.
- Trial name
- NCT02350010
- Testing
- CT Angiography
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Neurosurgical Institute
Complications of Surgical and Medical Care: General Terms, Adverse Reaction to Drug
The Thai Surgical Intensive Care Study (Thai-SICU Study)
The study observed the 28 days mortality of 9 participated University base surgical intensive care unit (SICU) as well as the occurrence of adverse events in SICU.
- Conditions
- Complications of Surgical and Medical Care: General Terms, Adverse Reaction to Drug, Sequelae of External Causes of Morbidity and Mortality, Critical Illness
- Trial name
- THAI-SICU (NCT01354197)
- Where
- 9 sites in Thailand
- Volunteers
- 4,652 people
- Sponsor
- Royal College of Anesthesiologists of Thailand
Urinary Bladder Neurogenic
Pharmacokinetics and Safety Study With Alfuzosin in Children and Adolescents With Elevated Detrusor Leak Point Pressure of Neuropathic Etiology
The primary objective is to investigate the pharmacokinetics (PK) of 2 doses of alfuzosin (given as a solution or tablets depending on age) in children and adolescents 2 to 16 years of age with elevated detrusor Leak Point…
- Trial name
- ALFACHIP (NCT00629720)
- Testing
- alfuzosin (SL770499)
- Where
- 2 sites in United States, Serbia
- Volunteers
- 29 people
- Sponsor
- Sanofi
Type 2 Diabetes
Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4
Hypoglycemia (low blood glucose level) occurs frequently in intensively treated patients with diabetes. Although hypoglycemia was thought to occur almost exclusively in T1DM, with the advent of improved metabolic control in T2DM…
- Trial name
- NCT00574340
- Testing
- Hyperinsulinemic Hypoglycemic Clamp
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Sepsis
Safety and Efficacy of Recombinant Human Platelet-Activating Factor Acetylhydrolase for the Treatment of Severe Sepsis
The objective of this study is to demonstrate that rPAF-AH is safe and reduces 28 day all cause mortality in patients with severe sepsis.
- Trial name
- NCT00037687
- Testing
- rPAF-AH
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- ICOS Corporation
Pain
Fentanyl for Treatment Pain Caused by Radiotherapy
The purpose of this study is to assess the clinical utility and safety of Fentanyl for pain treatment caused by radiotherapy. Fentanyl is a synthetic pure opioid agonist with a selective activity on µ receptors.
- Trial name
- NCT00523887
- Testing
- Fentanyl transdermal therapeutic system
- Volunteers
- 163 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Nausea and Vomiting Caused by Trastuzumab Deruxtecan
Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Trastuzumab Deruxtecan
This study aims to evaluate whether the preventive and suppressive effects of auricular point stimulation combined with dexamethasone on nausea and vomiting induced by trastuzumab deruxtecan are non-inferior to the standard…
- Trial name
- ADTD Ⅱ (NCT07716189)
- Testing
- Auricular point stimulation plus dexamethasone, Standard pharmacologic antiemetic regimen
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Antiphospholipid Syndrome
Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies.
This study is being done to see if there are any long term health related issues in women with APA and recurrent miscarriages.
- Trial name
- NCT00180817
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Imperial College London
Knee Osteoarthritis, Arthroplasty
An Attempt to Find Out Root Cause of a Pain Producing Knee Disease
This study was focused on a type of arthritis (knee) in which patients develop pain with disabilities in sitting and walking etc. In advance stage the person is bereft of his/her personal physical activities.
- Conditions
- Knee Osteoarthritis, Arthroplasty, Knee
- Trial name
- NCT04496440
- Testing
- Contracture Correction Therapy
- Where
- 6 sites in India
- Volunteers
- 138 people
- Sponsor
- DR R C Agrawal
Endodontically Treated Teeth, Root Canal Infection
Tooth Crown Discoloration Caused by Endodontic Treatment
The color change of endodontically treated teeth is a common concern in clinical practice. The objective of this study will be to evaluate, in vivo, the color change (ΔE00) caused by endodontic treatment.
- Conditions
- Endodontically Treated Teeth, Root Canal Infection, Tooth Discoloration
- Trial name
- NCT03841370
- Testing
- endodontic treatment
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
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