Clinical trials: Etiology
Atrial Fibrillation, Myocardial Ischemia
Minor Troponin Elevations in Patients With Atrial Fibrillation
This study aims at identifying the etiology of troponin-T elevations in patients with atrial fibrillation visiting the emergency department.
- Trial name
- Tropo-AF (NCT03683836)
- Testing
- No intervention
- Volunteers
- 3,394 people
- Sponsor
- University of Turku
Mycobacterium Infections, Nontuberculous
Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
The main objective of this study is to evaluate the efficacy of ALIS (amikacin liposome inhalation suspension) + background regimen (azithromycin [AZI] + ethambutol [ETH]) compared to the ELC (empty liposome control) + background…
- Trial name
- ENCORE (NCT04677569)
- Testing
- ALIS, Azithromycin, Ethambutol
- Where
- 258 sites in United States, Argentina and 21 more
- Volunteers
- 425 people
- Sponsor
- Insmed Incorporated
Anemia, Chronic Kidney Disease
Efficacy and Safety of Peginesatide (AF37702) in the Treatment of Anemia in Participants With Chronic Kidney Disease
The purpose of this study is to evaluate the ability of peginesatide (AF37702) to increase and maintain increased hemoglobin levels in participants with chronic kidney disease (CKD) (either not on dialysis, receiving regular…
- Conditions
- Anemia, Chronic Kidney Disease, Chronic Renal Failure, Pure Red Cell Aplasia
- Trial name
- NCT00314795
- Testing
- Peginesatide
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 22 people
- Sponsor
- Takeda
Temporomandibular Joint Disorder
Effect of Functional Treatment on Mandibular Asymmetric Growth
Temporomandibular joint (TMJ) arthritis is known to alter the mandibular development in children diagnosed with juvenile idiopathic arthritis.
- Trial name
- NCT01113177
- Testing
- Distraction splint therapy
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Malaria
Efficacy of GSK Biologicals' Candidate Malaria Vaccine 257049 Against Malaria Disease in Infants and Children in Africa
The purpose of this observer-blind study is to gather key efficacy, safety, and immunogenicity information on GSK's candidate malaria vaccine in infants and children.
- Trial name
- NCT00866619
- Testing
- Malaria Vaccine 257049, Meningococcal C Conjugate Vaccine, Cell-culture rabies vaccine
- Where
- 10 sites in Burkina Faso, Gabon and 5 more
- Volunteers
- 15,459 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Freezing of Gait, Parkinson's Disease
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related…
- Conditions
- Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism
- Trial name
- NCT07386015
- Testing
- Observational Data Collection
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin Huanhu Hospital
Irritable Bowel Syndrome, Sucrose Intolerance Due to Sucrase-Isomaltase Deficiency
Sucrase-isomaltase Deficiency as a Cause of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a functional disorder causing troublesome symptoms and reduced quality of life. It affects 10-20% of the population, hence creates large costs for society.
- Conditions
- Irritable Bowel Syndrome, Sucrose Intolerance Due to Sucrase-Isomaltase Deficiency, Carbohydrate; Malabsorption, Sucrase Isomaltase Deficiency
- Trial name
- NCT05159115
- Testing
- Low-FODMAP diet, Starch- and Sucrose Reduced Diet (SSRD)
- Volunteers
- 80 people
- Sponsor
- Lovisenberg Diakonale Hospital
Urologic Injuries, Disorder of Urinary Stent
Indwelling Stent Discoloration Project
The aim of this study is to identify the root cause for the significant discolouration of Boston Scientific Percuflex based stents.
- Conditions
- Urologic Injuries, Disorder of Urinary Stent, Kidney Calculi, Urinary Tract Obstruction Due to Specified Cause
- Trial name
- NCT02007980
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Multi-resistant Gram-negative Bacteria Cause Infection
GRAM NEGATIVES STUDY
This is a prospective, observational, multicenter study whose main objective is to develop a predictive model of mortality in critically ill patients colonized by multidrug-resistant Gram-negative bacteria (MDR-GNB).
- Trial name
- MR-GEIPC (NCT07749508)
- Testing
- Standard of care therapy
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Fundacion SEIMC-GESIDA
Iron-deficiency, Iron Deficiency Anaemia Due to Dietary Causes
Effect of Iron Supplements on the Growth of Enteric Pathogens
Iron supplementation is a common approach to address iron deficiency with recommendations for women of childbearing age, particularly those at risk of iron deficiency.
- Conditions
- Iron-deficiency, Iron Deficiency Anaemia Due to Dietary Causes, Iron Deficiency Anemia Treatment, Iron Deficiency Anemia
- Trial name
- NCT05762380
- Testing
- Ferrous sulfate, Ferrous sulfate-enriched Aspergillus oryzae (Ao iron)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Hyperhydrosis, Depression
Excessive Sweating Caused by Antidepressants: Measurement and Treatment With Glycopyrrolate (AIDES-G)
The study consists of measurement of antidepressant-induced excessive sweating and its treatment with an experimental medication, glycopyrrolate (approved to treat ulcers), which will be added to the antidepressant.
- Trial name
- AIDES-G (NCT01588717)
- Testing
- Glycopyrrolate
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Jefferson University
Obesity
Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.
This study aims to investigate genetic causes of early childhood obesity. The investigators will enroll children and adults with severe early onset obesity (BMI > 99th percentile) diagnosed prior to 6 years of age.
- Trial name
- GECO (NCT01998750)
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Columbia University
Acupuncture, Dexmedetomidine
Study on the Difference and Cause of Acupuncture Dexmedetomidine Compound Anesthesia Effect
Studies have shown that the use of dexmedetomidine before and during surgery has a good sedative, analgesic and circulatory stabilizing effect.
- Conditions
- Acupuncture, Dexmedetomidine, Anesthesia
- Trial name
- NCT05159674
- Testing
- Dexmedetomidine+electroacupuncture compound anesthesia
- Volunteers
- 22 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Patients withInfections Caused by S.Aureus Like Skin Infections , Chest Infections , Surgical Site Infections , and Urinary Tract Infections
Detection of Efflux Pump Genes Mediating Ciprofloxacin Resistance in Staphylococcus Aureus Isolates in Sohag University Hospitals
Among multidrug-resistant bacteria, Methicillin-resistant Staphylococcus aureus (MRSA) isolates were recognized to be an important mortality factor in hospital infections and a major concern in health-care and community settings…
- Trial name
- NCT05828550
- Testing
- antibiotic sensitivity
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Skin Barrier to Water Loss, Microbial Colonization
Oral Lactobacillus Reuteri for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of oral Lactobacillus reuteri supplementation for treating obesity-induced skin barrier impairment in individuals aged 18-40 with a BMI ≥30.
- Trial name
- NCT07512050
- Testing
- Oral Lactobacillus reuteri group, Oral administration of inactive Lactobacillus reuteri group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Chemotherapy-induced Peripheral Neuropathy, Nerve Pain
The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
This study is a randomized controlled trial of electroacupuncture (referred to as EA) versus sham acupuncture (referred to as EA) as effective treatments for Chemotherapy-Induced Peripheral Neuropathy (CIPN) pain in cancer…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Nerve Pain, Neuropathy, Neuropathy, Painful
- Trial name
- ACT (NCT04917796)
- Testing
- Electroacupuncture
- Where
- 6 sites in United States
- Volunteers
- 255 people
- Sponsor
- Dana-Farber Cancer Institute
Knee Arthritis
Skin to Adductor Canal Distance in Various Positions
To control pain after total knee replacement surgery a catheter (tubing) is sometimes inserted into an anatomic space containing nerves that provide sensation to parts of the knee. This space is called the adductor canal.
- Trial name
- Skin to AC (NCT03562559)
- Testing
- Measurements Using Ultrasound
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Cardiogenic Shock, Myocardial Infarction (MI)
BEAT-SHOCK Registry
This regulation defines the purpose, the operational processes, and the organization of the registry BEAT-SHOCK (Basel Evaluation of Acute Therapy in cardiogenic SHOCK).
- Conditions
- Cardiogenic Shock, Myocardial Infarction (MI), Fulminant Myocarditis, Acute Decompensated Heart Failure
- Trial name
- BEAT-SHOCK (NCT07643610)
- Testing
- no internvention
- Where
- Switzerland
- Volunteers
- 8,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Nausea and Vomiting, Chemotherapy-Induced, Chemotherapy-Induced Nausea and Vomiting
Study Of Prevention of Chemo-Induced Nausea and Vomiting Caused By Moderately Emetogenic Chemotherapy
This study was designed to assess the safety and efficacy of different dosages and administration schedules of an investigational agent administered over 3 days when added to standard therapy used in the prevention of…
- Trial name
- NCT00104403
- Testing
- GW679769, Dexamethasone, Ondansetron Hydrochloride
- Where
- 113 sites in United States, Argentina and 22 more
- Volunteers
- 722 people
- Sponsor
- GlaxoSmithKline
Myocarditis, Cardiomyopathy
Recurrent Acute Myocarditis Registry
The association between myocardial inflammation (clinically represented by acute myocarditis episodes) and the later development of an arrhythmogenic cardiomyopathy is widely elusive.
- Trial name
- RAM (NCT04589156)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
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