Clinical trials: Etiology
Hereditary Diseases
Study of Clinical and Molecular Manifestations of Genetic Disorders
This study will investigate the cause and natural history (medical problems that appear over time) of certain genetic disorders.
- Trial name
- NCT00001466
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Respiratory Insufficiency
Respiratory Weaning Following Cardiac Surgery.
Respiratory weaning failure worsens prognostic of patients following on-pump cardiac surgery. There are increasing evidences that pulmonary, diaphragmatic or cardiologic echographies are useful in order to improve this critical…
- Trial name
- ETCCCV (NCT02821429)
- Testing
- Combined Thoracic Echography Record
- Where
- France
- Sponsor
- University Hospital, Toulouse
Patients With Pulmonary Hypertension
Pulmonary Hypertension in Patients Attending Sohag University Hospital: A Focus on The Etiology
Assessment of pulmonary hypertension in patients attending Sohag university hospital ( in out patient clinic or in patient) focusing on the etiology of pulmonary hypertension
- Trial name
- NCT05207683
- Testing
- echocardiography
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Stargardt Disease, Stargardt Macular Degeneration
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)
This Phase 1/2 study will evaluate the safety, tolerability, and preliminary efficacy of subretinal SB-007 administration to determine dose selection in subjects with Stargardt's Type 1 (STGD1).
- Conditions
- Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy
- Trial name
- ASTRA (NCT06942572)
- Testing
- SB-007
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Splice Bio
Congenital Hereditary Endothelial Dystrophy of Cornea
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops
CHED- Congenital Endothelial Endothelial Dystrophy is a condition that causes corneal cloudiness. Since, currently only surgery is being done to cure this condition, we are taking up the research of using topical eye drops for…
- Trial name
- NCT04843839
- Testing
- Nepafenac 0.1% Oph Susp, Refresh Tears 0.5% Lubricant Eye Drops
- Where
- India
- Volunteers
- 30 people
- Sponsor
- L.V. Prasad Eye Institute
Critically Ill, Acute Kidney Injury
Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or…
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- CORRI (NCT01862588)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Early Apical Peri-implantitis
Etiology of Early Apical Peri-implantitis
A case-control study was performed was performed following the STROBE statement from 1996 to 2016 including patients who were diagnosed with early apical peri-implantitis.
- Trial name
- EAP (NCT03523845)
- Testing
- Observational intervention to diagnose an early apical peri-implantitis
- Volunteers
- 46 people
- Sponsor
- University of Valencia
Nausea, Vomiting
Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy
RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy.
- Conditions
- Nausea, Vomiting, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00429702
- Testing
- Decadron®, Benadryl®, Ativan®
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 7 people
- Sponsor
- University of South Florida
Clinically Significant Bacteremia, Organ Transplantation
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carbapenemase-producing Enterobacterales in Solid Organ Transplantation: an Observational Multinational Study.
Main objective: to observationally assess the efficacy and safety of different antimicrobials in BSI due to ESBL or carbapenemase-producing Enterobacterales in SOT. Secondary objectives: 1.
- Conditions
- Clinically Significant Bacteremia, Organ Transplantation, Infection, Bacteremia
- Trial name
- INCREMENT-SOT (NCT02852902)
- Where
- 3 sites in Spain
- Volunteers
- 820 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Low Back Pain, Medicine, Korean Traditional
The Effectiveness and Safety of T-MSAT on Inpatients With Acute Low Back Pain Caused by Traffic Accidents : A Randomized Controlled Trial
This study is a single blind, randomized controlled trial. condition/disease: acute low-back pain treatment/intervention: Motion Style Acupuncture Treatment using Traction (T-MSAT)
- Trial name
- NCT04554446
- Testing
- T-MSAT(Motion style acupuncture treatment using traction), Korean medicine treatment
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Jaseng Medical Foundation
Reperfusion Injury
Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.
- Trial name
- NCT02394405
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Breast Cancer, Chemotherapy
A Pilot Study to Evaluate the Safety and Activities of EW02 in Reducing Neutropenia Caused by Chemotherapy
Study Hypothesis: EW02 is a polysaccharide-enriched crude extract from black soybean (BS). BS has been used extensively by the Chinese as food or traditional Chinese medicine for hundreds of years.
- Conditions
- Breast Cancer, Chemotherapy, Neutropenia
- Trial name
- NCT00555516
- Testing
- EW02
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
E.Coli Infections
Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli (EXPECT-1)
The purpose of this study is to collect information from study participants who develop an invasive disease caused by Extraintestinal pathogenic E. coli (ExPEC) during a period of 12 months.
- Trial name
- EXPECT-1 (NCT04087681)
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 4,479 people, healthy volunteers welcome
- Sponsor
- MJM Bonten
Acute Pain Management, Analgesic, Nonopioid
A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery
The purpose of this pilot study is to test the safety of oral ketamine to treat acute pain after amputation surgery. The objective of the proposed research is to conclusively determine if oral ketamine is a safe alternative…
- Conditions
- Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
- Trial name
- NCT02341963
- Testing
- Oral Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Arthritis of Knee
Hyperpronation and Foot Pain
Effects of training and pellots
- Trial name
- NCT00736138
- Testing
- training and pellots
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Community Acquired Pneumonia
Community Acquired Pneumonia in Telemark and Ostfold
The aim of the study is to investigate the bacterial causes in community acquired pneumonia in adults admitted to hospital in two counties in Norway and to look at possible factors that makes the patients susceptible to pneumonia.
- Trial name
- CAPITO (NCT00467701)
- Where
- Norway
- Volunteers
- 380 people
- Sponsor
- Sykehuset Telemark
MYT1L Syndrome
MYT1L Syndrome: a Rare Paediatric Genetic Syndrome Responsible for a Neurodevelopmental Disorder
MYT1L syndrome is a rare genetic syndrome, recently described in 2011, with paediatric onset, responsible for a neurodevelopmental disorder combining psychomotor retardation, learning difficulties and/or intellectual development…
- Trial name
- MYT1L (NCT07008612)
- Testing
- Patients with a genetic syndrome linked to the MYT1L gene, Patients with a neurodevelopmental disorder of genetic origin but not linked to MYT1L
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Rouen
Gastric Cancer, Colorectal Cancer
E. Coli Nissle in Oncology
In patients with gastric or colorectal cancers, where a treatment with 5-Fluoruracil in combination with other chemotherapeutic remedies (FLO, FOLFOX, FOLFOX-Bev, FOLFIRI) is planned, it shall be investigated whether E.
- Trial name
- EcNO (NCT02706184)
- Testing
- E. coli Nissle suspension
- Where
- 5 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University of Hohenheim
Bacteremia Caused by Gram-Negative Bacteria, Bacterial Pneumonia
A Post-Marketing Study to Assess the Efficacy and Safety of Intravenous Polymyxin B and Colistin Methanesulfonate in Patients With Carbapenem-Resistant Gram-Negative Bacterial Infection
This is a retrospective, observational, post-marketing study to evaluate the clinical response, microbiological response, mortality, and safety of intravenous polymyxin B and colistin methanesulfonate in patients with…
- Trial name
- NCT06966284
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- TTY Biopharm
Subjects With Severe, Refractory Sclerotic Skin Changes
Ablative Fractional Laser for Sclerotic GVHD-Associated Joint Contractures
Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplant.Chronic GVHD is characterized by skin thickening and tightening.
- Trial name
- NCT02881047
- Testing
- CO2 Laser, Ultrasound, Skin Biopsy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.