Clinical trials: Etomidate
Adrenal Suppression, Hemodynamic Instability
THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients
Compare the efficacy and safety of closed-loop target controlled infusion of propofol or etomidate at general anesthesia in geriatric patients
- Trial name
- NCT02111265
- Testing
- Remifentanil, Cisatracurium, Sufentanil
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
General Anesthesia
Safety and Efficacy of Maintenance of Etomidate in General Anesthesia
This study was designed to use etomidate combined with sevoflurane intravenously to maintain anesthesia process under the monitoring of BIS. Propofol was used as the controls.
- Trial name
- NCT05223907
- Testing
- Etomidate, Propofol
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Henan Provincial People's Hospital
Schizophenia Disorder, Major Depression Disorders
Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment
The goal of this clinical trial is to find if patients would awaken quickly after electroconvulsive treatment when remimazolam is used compared to etomidate. It will also learn about the efficacy of remimazolam.
- Conditions
- Schizophenia Disorder, Major Depression Disorders, Schizoaffective Disorder, Bipolar
- Trial name
- NCT06664138
- Testing
- Remimazolam, Etomidate
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yeongseok Yun
Interaction Drug Food
Drug Interactions Trial of Methoxyethyl Etomidate Hydrochloride
Sixty-eight healthy subjects were divided into three sequences: A, B and C. The effects of CYP2C19 inhibitor fluconazole and inducer rifampicin on ET-26-HCl injection were evaluated, and the effects of ET-26-HCl injection on…
- Trial name
- NCT06822166
- Testing
- rifampicin, Fluconazole, Omeprazole
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Trauma
The Effect of Etomidate on Outcomes of Trauma Patients
Rationale: The drug etomidate causes increased mortality if used for continuous sedation in mechanically ventilated patients; however, etomidate continues to be widely used as a single-bolus induction agent for endotracheal…
- Trial name
- NCT00938990
- Testing
- Etomidate, Midazolam
- Sponsor
- Advocate Hospital System
Cardiopulmonary Arrest, Respiratory Arrest
Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life.
- Trial name
- EvK (NCT02643381)
- Testing
- Etomidate, Ketamine, Emergency Endotracheal Intubation
- Where
- United States
- Volunteers
- 801 people
- Sponsor
- University of Texas Southwestern Medical Center
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Cardiac Surgery
Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC
Because of its hemodynamic safety, etomidate is widely used for anaesthesia induction of cardiac surgery. It can also cause adrenal insufficiency during the following 48 hours ( 11 betahydroxylase inhibition ).
- Trial name
- NCT00451776
- Testing
- etomidate, propofol
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Insomnia, Digestive Endoscopy
Changes in Etomidate Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
To compare the dosage requirement of etomidate under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT07028177
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Postpartum Hemorrhage
Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
Poor uterine tone after the birth of a baby may cause serious bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide. In the developed world the cesarean section rate is increasing.
- Trial name
- NCT03852797
- Testing
- Oxytocin, Ketamine, Propofol
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Bispectral Index, Pediatric
Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction
This research through using bispectral index to guide the induced dose and speed of etomidate lipid emulsion for pediatric total venous anesthesia,and to provide a reference for clinical anesthesia physician.
- Conditions
- Bispectral Index, Pediatric, Etomidate, Induction
- Trial name
- NCT02182648
- Testing
- etomidate, propofol, sevoflurane
- Volunteers
- 120 people
- Sponsor
- Henan Provincial People's Hospital
Coronary Artery Disease, Valvular Heart Disease
The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone
During induction for cardiac surgery, patient hemodynamic stability is achieved by using anesthetic drugs which least affects hemodynamics such as benzodiazepines, etomidate.
- Trial name
- NCT01495949
- Testing
- etomidate, thiopentone
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Mahidol University
Etomidate, Esketamine
Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children
Objective: To explore the effect of etomidate and esketamine on postoperative pain after tonsillectomy in children. Methods: Investigators enrolled 64 children with American Society of Anesthesiologists (ASA) physical status I…
- Conditions
- Etomidate, Esketamine, Tonsillectomy, Children
- Trial name
- NCT07062601
- Testing
- Etomidate and fentanyl group, Etomidate and esketamine group
- Volunteers
- 64 people
- Sponsor
- Anqing Municipal Hospital
Adrenocortical Abnormality
Cortisol Level After Repeated Doses of Etomidate
The aim of this study is to investigate the effect of repeated doses of etomidate on the adrenocortical synthesis of corticosteroids in patients aged 18 to 65, ASA status I to III scheduled to electroconvulsive therapy every 2…
- Trial name
- NCT03188029
- Testing
- adrenocortical function
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- University Tunis El Manar
Pharmacokinetics
Substance Balance Trial of Methoxyethyl Etomidate Hydrochloride
This study was a single-center, single-dose, open-label design with 6-8 healthy adult male subjects to evaluate the body material balance of [14C]ET-26.
- Trial name
- NCT06822114
- Testing
- Methoxyethyl Etomidate Hydrochloride
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
General Anesthesia
Effect of Etomidate and Propofol on Electroencephalography
Electroencephalography (EEG) monitoring reflect the brain electro-activity. Different anesthetics may show different changes in EEG during anesthesia. Etomidate and propofol are widely used for general anesthesia.
- Trial name
- CHAPE (NCT04369014)
- Testing
- etomidate anesthesia, propofol anesthesia
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Air Force Military Medical University, China
Hepatic Insufficiency
Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
A Phase I clinical study to compare the pharmacokinetics, pharmacokinetics, and safety of intravenous administration of methoxyetomidate hydrochloride for injection in subjects with mild hepatic insufficiency (Child-pugh A)…
- Trial name
- NCT06176716
- Testing
- ET-26
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Post-Traumatic Stress Disorder, Acute Respiratory Failure
Effect of Ketamine and Etomidate During RSI on Long Term Outcomes
The RSI-LTO study collects long-term outcomes from the RSI trial (NCT05277896). One-third of adults who are intubated in the ED or ICU experience symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- RSI-LTO (NCT06179485)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 1,756 people
- Sponsor
- Vanderbilt University Medical Center
Etomidate, Hypotension
The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol in total intravenous anesthesia during abdominal surgery.
- Trial name
- NCT05810363
- Testing
- Etomidate - propofol mixture, Propofol
- Where
- China
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Ailin Luo