Clinical trials: Evidence of Liver Transplantation
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Autoimmune Disease, Juvenile Idiopathic Arthritis
Immunogenicity of HPV Vaccine in Immunosuppressed Children
Genital HPV is the necessary cause for cervical cancer, as well as a major contributing cause of several other cancers and conditions. There are now effective vaccines against the main oncogenic HPV types, HPV16 and 18.
- Conditions
- Autoimmune Disease, Juvenile Idiopathic Arthritis, Inflammatory Bowel Disease, Evidence of Liver Transplantation
- Trial name
- NCT02263703
- Testing
- Quadrivalent HPV vaccine
- Where
- Australia
- Volunteers
- 55 people
- Sponsor
- The University of New South Wales
Non-alcoholic Fatty Liver Disease, Evidence of Liver Transplantation
Quantifying Steatosis in Liver Transplant Donors
Non-alcoholic fatty liver disease is the most common chronic liver disease in Hong Kong. Its presence among donors of living donor liver transplants could affect the outcomes of recipients of liver transplantation.
- Trial name
- NCT02579408
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Evidence of Liver Transplantation, Rejection
Safety and Efficacy of Alemtuzumab in Pediatric Intestinal Transplantation
This open-label clinical trial will evaluate the safety and efficacy of Alemtuzumab (Campath, Bayer Corp., Pittsburgh) in children (0-17) and adults (18-25) receiving intestinal transplant.
- Conditions
- Evidence of Liver Transplantation, Rejection, ALEMTUZUMAB
- Trial name
- NCT01208337
- Testing
- Alemtuzumab
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
Sequelae of Viral Hepatitis, Transplantation Infection
Randomized Phase II Study of Hepatitis C Immune Globulin Intravenous (Human), Civacir(TM), in Liver Transplantation
A Phase 2 study to evaluate safety, pharmacokinetics and efficacy of Hepatitis C Immune Globulin Intravenous (human) [Civacir(TM)] for preventing or reducing the impact of recurrent HCV infection following liver transplantation.
- Conditions
- Sequelae of Viral Hepatitis, Transplantation Infection, Evidence of Liver Transplantation
- Trial name
- NCT00473824
- Testing
- Hepatitis C Immune Globulin Intravenous (Human) 5%
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- ADMA Biologics, Inc.
Evidence of Liver Transplantation
Evaluate the Efficacy and Safety of the ADVAGRAF®
The primary objective of this study is to evaluate the efficacy of 6-month treatment with Advagraf® converted from 12-month treatment with tacrolimus in stable liver transplant recipients.
- Trial name
- STABLE (NCT04763096)
- Testing
- Advagraf
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Linical Korea
Hepatocellular Carcinoma, Liver Cirrhosis
Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma (HCC)
Results of liver transplantation, the best theoretical treatment for HCC, are limited by tumor recurrence. In order to limit this risk Milan criteria was proposed in 1996.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Evidence of Liver Transplantation
- Trial name
- EFAPRE (NCT01198704)
- Testing
- search of factors predicting tumor recurrence
- Where
- France
- Volunteers
- 372 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Tumor, Evidence of Liver Transplantation
Combination of Cryosurgery and NK Immunotherapy for Tumors in Transplanted Liver
The aim of this study is the safety and efficacy of cryosurgery plus natural killer(NK) immunotherapy to tumors in transplanted liver.
- Trial name
- NCT02849015
- Testing
- Cryosurgery, NK immunotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Evidence of Liver Transplantation
Safety, Efficacy of Eglandin® in Living Donor Liver Transplanted Patient (PROVISION)
The purpose of this study is to evaluate superiority of Eglandin® (Alprostadil) 720㎍compared to 360㎍ in terms of safety, efficacy in living donor liver transplant patient, peak AST levels followed by Eglandin administration were…
- Trial name
- PROVISION (NCT02350218)
- Testing
- Eglandin
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Evidence of Liver Transplantation, Arterial Occlusive Diseases
Clinical Benefits of B-Flow Ultrasound
The goals of this study are to evaluate the efficacy of the B-flow capability on the LOGIQ E9 system in three clinical focus areas. 1.
- Conditions
- Evidence of Liver Transplantation, Arterial Occlusive Diseases, Hypertension, Pregnancy, High Risk
- Trial name
- NCT02008097
- Testing
- GE LOGIQ E9 Ultrasound System
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Washington
Evidence of Liver Transplantation
Changes of Macrophage Migration Inhibitory Factor During Orthotopic Liver Transplantation
Collecting blood, graft liver effluent and urine samples from patients undergoing orthotopic liver transplantation.
- Trial name
- NCT02695979
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Evidence of Liver Transplantation
A Pilot Trial of Pediatric Liver Transplantation Without Steroids
Objective: The overall objective is to investigate whether a steroid free immunosuppressive regimen is as safe and effective as a steroid containing regimen following pediatric liver transplantation and whether it promotes…
- Trial name
- NCT00694408
- Testing
- methyl prednisolone, hydrocortisone, prednisolone, No steroids
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Evidence of Liver Transplantation, Myocardial Injury
Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation
The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation
- Trial name
- NCT03013634
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin First Central Hospital
Evidence of Liver Transplantation, Hyperglycemia
Study of Glycemic Control on Liver Transplantation Outcomes
Many but not all studies have shown improvement in morbidity and mortality with intensive glycemic management postoperatively. In this study, the investigators propose to determine whether improved glycemic control using…
- Conditions
- Evidence of Liver Transplantation, Hyperglycemia, Rejection
- Trial name
- NCT01211730
- Testing
- Insulin
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Northwestern University
Evidence of Liver Transplantation, Effects of Immunosuppressant Therapy
Determining Equivalence Dose for Oral Versus Sublingual Administration of Tacrolimus in Hepatic Receptors
After liver transplantation one of the most important cost, for both patients and their health insurance system, is immunosuppressive drug therapy.
- Trial name
- FKosl (NCT02608606)
- Testing
- Tacrolimus
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Liver Cirrhosis, Hepatocellular Carcinoma
Safety Study of Liver Natural Killer Cell Therapy for Hepatoma Liver Transplantation
The objective of this study is to evaluate feasibility and safety of the adoptive transfer of activated natural killer (NK) cells extracted from cadaveric donor liver graft perfusate for liver transplant recipients with…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Evidence of Liver Transplantation
- Trial name
- MIAMINK (NCT01147380)
- Testing
- Liver NK cell inoculation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seigo Nishida
Evidence of Liver Transplantation
Cefepime Pharmacokinetics in Liver Transplant Recipients in an Intensive Care Unit
The purposes of this study are to: I. Characterize the plasma concentration-time profile of cefepime in liver transplant patients to determine the pharmacokinetic parameters in this patient population. II.
- Trial name
- NCT00177931
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Hepatitis C, Evidence of Liver Transplantation
Pilot Study of Hepatitis C Virus Entry Inhibitor (ITX 5061) in Liver Transplant Recipients
This is a phase I pilot study to determine the safety and preliminary efficacy of a novel hepatitis C virus (HCV) entry inhibitor (ITX 5061) in patients with HCV infection undergoing liver transplantation.
- Trial name
- ITX5061 (NCT01292824)
- Testing
- ITX 5061
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Birmingham
Evidence of Liver Transplantation
Clinical Trial of Hydrogen-Rich Celsior Solution Applied in Aging DBD Liver/Kidney Transplantation
The purpose of this study is to investigate whether hydrogen-rich Celsior solution improve the quality of aging grafts in liver/kidney transplantation.
- Trial name
- HRCSDBD (NCT02613195)
- Testing
- Hydrogen-Rich Celsior Solution
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Evidence of Liver Transplantation
Usefulness of Alpha-GST in Liver Transplantation
The primary objective of this study was to evaluate the ability of plasma alpha-GST measurements in liver donor (at the time of organ removal) to predict primary dysfunction in liver recipient.
- Trial name
- GST-LT (NCT02451046)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Beaujon Hospital