Clinical trials: Evidence-Based Medicine
ADHD, Substance Use Disorders
Integrated Treatment for Adolescents With ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) exists in 20-50% of the 3 million adolescents annually enrolled in outpatient mental health and substance use treatment.
- Trial name
- CASALEAP IT2A (NCT02420990)
- Testing
- Medication Integration Protocol (MIP), Changing Academic Support in the Home for Adolescents with ADHD (CASH-AA)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Prostate Cancer
Shared Decision Making: Prostate Cancer Screening
Interventions to Improve Shared Decision-Making: Prostate Cancer Screening is a prospective study of educational interventions to improve the interaction of physicians and their patients about prostate cancer screening.
- Trial name
- NCT00207649
- Testing
- Shared decision-making for PSA screening tool
- Where
- United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- Lisa Richarson
HIV Infections
Midwest TXTXT Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence
This research study uses a cluster randomized controlled trial design to evaluate the effectiveness of Treatment Text (TXTXT) intervention on adherence and viral load suppression at 3- and 6- months post intervention initiation…
- Trial name
- NCT05783297
- Testing
- Treatment Text (TXTXT), Standard of Care
- Where
- 12 sites in United States
- Volunteers
- 210 people
- Sponsor
- Amy K. Johnson, PhD, MSW
Multiple Sclerosis
Interactive Web Platform for EmPOWERment in Early Multiple Sclerosis
This randomized controlled trial with an accompanying process evaluation investigates the hypothesis that behavioural and web-based information on immunotherapy decisions, disease management and lifestyle can change patient…
- Trial name
- POWER@MS1 (NCT03968172)
- Testing
- EBBC programme, Control group programme
- Where
- Germany
- Volunteers
- 234 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Health Knowledge, Attitudes, Practice
Evaluation of Educational Intervention to Teach Principles of Evidence-based Medicine (EbM) in Biology Classes
The purpose of this study is to identify the effect of a short term educational intervention for upcoming biology teachers to teach principles of Evidence-based Medicine (EbM) and Good Scientific Practice (GSP) to high-school…
- Trial name
- NCT01567267
- Testing
- Experimental educational intervention, Standard educational intervention
- Where
- Germany
- Volunteers
- 87 people
- Sponsor
- Goethe University
Depressive Disorder, Anxiety Disorder
Collaborative and Stepped Care in Mental Health (COMET)
The aims of COMET are the implementation and evaluation of effectiveness and cost-effectiveness as well as processes of a collaborative and stepped care model for depressive, anxiety, somatoform and/or alcohol abuse disorders…
- Conditions
- Depressive Disorder, Anxiety Disorder, Somatoform Disorder, Alcohol Use Disorder
- Trial name
- COMET (NCT03226743)
- Testing
- collaborative and stepped care model
- Where
- Germany
- Volunteers
- 615 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation, Arterial Hypertension
Improvement Adherence to Clinical Practice Guidelines Using the Clinical Decision Support System in Patients With Hypertension and Atrial Fibrillation
The Clinical Decision Support Systems (CDSS) based on real clinical data and its own algorithms can help to make the right choice according to guidelines.
- Trial name
- INTELLECTII (NCT05367141)
- Testing
- CDSS ("MedicBK")
- Where
- Russia
- Volunteers
- 282 people
- Sponsor
- Samara Regional Cardiology Dispensary
Diabetes, Prediabetes
Meta-analyses of the Effect of Tree Nuts on Glycemic Control and Features of the Metabolic Syndrome
Tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamia nuts, pecans, pine nuts, pistachios and walnuts) are an important source of unsaturated fatty acids, vegetable protein, and fibre, as well as minerals, vitamins, and…
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01630980
- Testing
- Tree nuts
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Adolescent Substance Use
Enhancing Juvenile Drug Court Outcomes With Evidence-Based Practices
Juvenile drug courts were developed in response to a perceived need to intervene more effectively with youth with substance abuse problems.
- Trial name
- NCT01266109
- Testing
- Contingency Management-Family Engagement (CM-FAM), Usual Services (US)
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Medical University of South Carolina
Obesity, Dyslipidemia
Meta-analyses of the Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1)…
- Conditions
- Obesity, Dyslipidemia, Prediabetes, Dysglycemia
- Trial name
- NCT02702479
- Testing
- High Fructose Corn Syrup, Sucrose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2
Impact of an Evidence-based Electronic Decision Support System on Diabetes Care
The purpose of this study is to assess the feasibility of the use of an evidence-based decision support system (EBMeDS) in daily Belgian family medicine and to study the effectiveness of EBMeDS use on improving diabetes care.
- Trial name
- NCT01830569
- Testing
- The EBMeDS system, Evidence Linker
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- KU Leuven
Angina Pectoris
Treatment of Angina Pectoris After Coronary Revascularization With Integrated Traditional Chinese and Western Medicine
This study used a multicenter, prospective cohort study. According to whether they received TCM treatment and the degree of exposure to TCM, the cohorts were divided into strong TCM exposure group, TCM exposure group, weak TCM…
- Trial name
- NCT05482009
- Testing
- Traditional Chinese Medicine Treatment Combined with Western Medicine Basic Treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Tennis Elbow, Musculoskeletal Diseases
Trial of Physiotherapy and Corticosteroid Injections in Lateral Epicondylalgia
This randomised controlled trial will evaluate the role of manual therapy and therapeutic exercise and corticosteroid injections in the treatment of lateral epicondylalgia (tennis elbow).
- Trial name
- NCT00110318
- Testing
- Manual therapy and therapeutic exercise, Corticosteroid injections
- Where
- Australia
- Volunteers
- 198 people
- Sponsor
- The University of Queensland
Cocaine Use Disorder
Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
The proposed work will investigate changes in brain signaling and cognitive functioning that support recovery from addiction, as well as use of pretreatment neurocognitive functioning to inform substance use treatment planning.
- Trial name
- WRAP (NCT03799341)
- Testing
- Prize-Based Contingency Management, Treatment As Usual Outpatient Substance Use Treatment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Cardiovascular Diseases
Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study)
This study used the diabetes prevention and follow-up research queue in Daqing and the public database of UKbiobank to evaluate the risk factors of cardiovascular and cerebrovascular events in diabetes patients, and built the…
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Cerebrovascular Disease
- Trial name
- NCT06959784
- Testing
- semaglutide, Metformin
- Where
- China
- Volunteers
- 142 people
- Sponsor
- China-Japan Friendship Hospital
Healthy Volunteer
OrthoEvidence Trial Assessing Japanese Knowledge Updates
The purpose of this randomized controlled trial is to clarify whether providing translated evidence summary (Advanced Clinical Evidence (ACE) reports from OrthoEvidence) will increase the access to the summary compared to…
- Trial name
- OTAKU (NCT05250622)
- Testing
- Japanese-translated evidence summaries (Advanced Clinical Evidence report from OrthoEvidence), English evidence summaries (Advanced Clinical Evidence report from OrthoEvidence)
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- McMaster University
Lumbar Degenerative Disease, Shared Decision Making
Effectiveness of Implementing Shared Decision-Making on Quality of Care Among Patients With Lumbar Degenerative Diseases.
Background: Shared decision making (SDM) is a patient-centered and evidence-based model of clinical decision making. The feature of SDM is that clinicians work together with patients to plan the most appropriate and practical…
- Conditions
- Lumbar Degenerative Disease, Shared Decision Making, Patient Decision Aids, Evidence-based Medicine
- Trial name
- NCT03679494
- Testing
- Shared decision making support tool
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Depression
Cluster Randomized Trial of Stepped Care Intervention vs. Treatment as Usual for Patients With Depression
The main aim of the project is the implementation and evaluation of a stepped care model (SCM) for patients with depression with 6 treatment options of varying intensity and setting, including innovative technologies (e-mental…
- Trial name
- SCM (NCT01731717)
- Testing
- Active monitoring, Bibliotherapy, Online self-help
- Where
- Germany
- Volunteers
- 737 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf