Clinical trials: Evidence-based Medicine
Evidence Based Medicine
Use of Wikis and Evidence-Based Medicine in Surgical Practice
The goal of this study is to improve surgical residents' skills in critically appraising the literature and to promote the dissemination and application of the best available evidence to surgical practice.
- Trial name
- NCT01051050
- Testing
- Mandatory use of surgery wiki, Voluntary use of the surgery wiki
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Opiates, Healthy
Factors Affecting Methamphetamine and Opiates Drug Testing
Background: Some legal over-the-counter drugs (such as Vicks VapoInhaler ) and some foods (such as poppy seeds) may cause a positive screening drug test.
- Trial name
- NCT01736332
- Testing
- Vicks VapoInhaler, Poppy seeds
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Overweight, Obesity
Network Meta-analyses of Artificially Sweetened Beverages and Cardiometabolic Risk
Sugars especially in form or sugar-sweetened beverages (SSBs) have been singled out as one of the prime culprits in the dual epidemics of obesity and diabetes.
- Trial name
- NCT02879500
- Testing
- Diet beverages
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Healthy Volunteer
OrthoEvidence Trial Assessing Japanese Knowledge Updates
The purpose of this randomized controlled trial is to clarify whether providing translated evidence summary (Advanced Clinical Evidence (ACE) reports from OrthoEvidence) will increase the access to the summary compared to…
- Trial name
- OTAKU (NCT05250622)
- Testing
- Japanese-translated evidence summaries (Advanced Clinical Evidence report from OrthoEvidence), English evidence summaries (Advanced Clinical Evidence report from OrthoEvidence)
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- McMaster University
Substance Use
Rapid Adaptation to Prevent Drug Use
Using a 2-group, mixed method cluster randomized trial design, this study will compare standard implementation versus RAPD implementation strategy in Michigan Middle Schools
- Trial name
- RAPD (NCT05806840)
- Testing
- Rapid Adaptation to Prevent Drug Use (RAPD), Standard Implementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Hypertension
VISN Collaborative for Improving Hypertension Management With ATHENA-HTN
This project is a VA HSR\&D-funded Quality Enhancement Research Initiative (QUERI) project to translate into practice evidence about clinical management of primary hypertension.
- Trial name
- HTN (NCT00374452)
- Testing
- ATHENA-CDS-HTN plus Guideline Link, Guideline Link Only
- Where
- 7 sites in United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypertension, Hyperlipidemia
The Effect of Providing Free Samples of Generic Cardiovascular Medications to Physicians
In this randomized controlled trial, we will provide primary care physicians with free samples of highly effective generic cardiovascular medications.
- Trial name
- SAMPLES (NCT00761904)
- Testing
- Free Generic Samples (hydrochlorothiazide, simvastatin)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
CONTINUING MEDICAL EDUCATION
Development and Evaluation of Hygie, a New Serious Game for Continuing Medical Education of General Practitioners
We produced a prototype video game called Hygie on the 5 most common reasons of consultation in general practice using 9 articles from independent journals based on evidence (reviews by Prescrire and Minerva).
- Trial name
- NCT03486275
- Testing
- Hygie, Source articles
- Where
- France
- Volunteers
- 3,398 people, healthy volunteers welcome
- Sponsor
- Hygie
Decision Making
Practice Guidelines Grading Systems
Clinical practice guidelines (CPG) are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances.
- Trial name
- NCT00940290
- Testing
- Graded Clinical Recommendation
- Where
- Mexico
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Smoking Cessation
Integrating Smoking Cessation Into Routine Primary Care Practice
The aim of this study is to determine if providing smokers identified in family doctors offices with follow-up counselling enhances their success with quitting and the number of health professionals helping patients with…
- Trial name
- NCT00799279
- Testing
- Smoking cessation training, support, and telephone follow-up, smoking cessation intervention
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Meta-analyses of Impotrant Food Sources of Sugars and Incident Cardiometabolic Diseases
There is an urgent need for stronger evidence to support recommendations for the role of sugars in diabetes and related cardiometabolic diseases.
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome X, Hypertension, Cardiovascular Diseases
- Trial name
- NCT02702375
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Substance Abuse
Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders
The main objective of this study is to evaluate the effectiveness of including an interactive, web-based version of the Community Reinforcement Approach (CRA), called the Therapeutic Education System (TES), as part of…
- Trial name
- CTN-0044 (NCT01104805)
- Testing
- Therapeutic Education System (TES), Treatment-as-Usual (TAU)
- Where
- 10 sites in United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Evidence-Based Medicine
Using a Systematic Review in Clinical Decision Making: a Pilot Parallel, Randomized Controlled Trial
The purpose of this pilot study is to determine the feasibility of running a full-scale trial that compares two formats of a shortened systematic review to a full-length systematic review to be used in clinical decision-making.
- Trial name
- NCT02414360
- Testing
- Shortened Format, Full Length
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Otitis Media, Allergic Rhinitis
A Trial of Point of Care Information in Ambulatory Pediatrics
Does presentation of clinical evidence for decision making at point-of-care improve prescribing patterns in ambulatory pediatrics?
- Conditions
- Acute Otitis Media, Allergic Rhinitis, Sinusitis, Constipation
- Trial name
- NCT00368823
- Testing
- Electronic point-of-care delivery system
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cardiovascular Diseases, Diabetes
Diabetes Remote Intervention to improVe Use of Evidence-based Medications
A randomized remote, implementation trial in the Mass General Brigham network was performed on 200 patients with T2D at high CV or kidney risk.
- Trial name
- DRIVE (NCT06046560)
- Testing
- SGLT2 inhibitor, GLP-1 RA, Education-First
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Polypharmacy, Multiple Chronic Conditions
Protocol for a Multi-site Pilot Study of the OptiMed Clinical Trial
Background: Optimal medication management is one of the essential preconditions for polymedicated home-dwelling older adults with multiple chronic conditions to remain at home and preserve their quality of life and autonomy.
- Trial name
- OptiMed (NCT06688591)
- Testing
- Intervention programme to optimise medication management and prevent MRPs
- Volunteers
- healthy volunteers welcome
- Sponsor
- HES-SO Valais-Wallis
Substance Abuse
Testing ALERT With GTO in Middle Schools
To test the efficacy of Project ALERT with the support enhancement tool, Getting To Outcomes.
- Trial name
- GTO-ALERT (NCT05219422)
- Testing
- Project ALERT, Getting to Outcomes
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- RAND
Obesity, Dyslipidemia
Meta-analyses of the Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1)…
- Conditions
- Obesity, Dyslipidemia, Prediabetes, Dysglycemia
- Trial name
- NCT02702479
- Testing
- High Fructose Corn Syrup, Sucrose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto