Clinical trials: Exanimation
Hepatic Failure, Hepatic Impairment
Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects
The objective was to determine if hepatitis C virus (HCV) infection or mild to severe hepatic impairment (Child-Pugh Classes A, B, and C) altered the PK of buprenorphine, norbuprenorphine, or naloxone.
- Conditions
- Hepatic Failure, Hepatic Impairment, Chronic Hepatitis C Infection With Hepatic Coma
- Trial name
- NCT01846455
- Testing
- 2.0mg Buprenorphine/0.5mg Naloxone, Promethazine
- Where
- 3 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Brain Death
Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ Donation
The study aims to gather information regarding the individual perceptions, opinions, beliefs, and conceptual understanding of healthcare professionals working in the intensive care units at the University Hospital Basel, the…
- Trial name
- DISCOVER (NCT06640088)
- Where
- Switzerland
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Brain Death
Optical Assessment on Brain Death Via a Oxygen Supply Procedure
This study aims to evaluate brain death with optical probes. The changes of hemodynamic parameters including oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) were detected by near infrared spectroscopy probes attached on the…
- Trial name
- NCT03864887
- Testing
- Oxygen supply of high-low-high procedure, Oxygen supply of low-high-low procedure, Optical monitor for hemodynamic parameter.
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Brain Death
Neurophysiological Examination in Patients With Brain Death
This study examines muscle movements of elecromyography in adults with brain death. Half of the participants will have brain death, the other half will be healthy volunteers.
- Trial name
- NCT03262896
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Brain Death, Coma
Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
This study aims to assess brain death and deep coma with the self-made near infrared spectroscopy (NIRS) instrument. The investigators used the noninvasive method to monitor the Δ[HbO2] (the concentration changes in…
- Trial name
- NCT04623294
- Testing
- Oxygen supply of high-low-high procedure, Oxygen supply of low-high-low procedure
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Patients With Traumatic Brain Injury, Coma, Traumatic
Family-Centered Affective Stimulation for Patients With Traumatic Brain Injury: Its Effects on Coma Recovery
Family-centered affective stimulation involves creating an environment in which family members actively participate in the patient's recovery by providing emotional support, positive reinforcement, and a supportive presence.
- Trial name
- NCT07537023
- Testing
- Family-Centered Affective Stimulation (FCAS)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Trauma, Shock, Traumatic
Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study
We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG.
- Conditions
- Trauma, Shock, Traumatic, Morality
- Trial name
- NCT05549986
- Testing
- Observational
- Volunteers
- 105,641 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Brain Death
Thyroxine Replacement in Organ Donors
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
- Trial name
- NCT00238030
- Testing
- L-thryoxine, iv thryoxine
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Brain Death, Renal Failure
Understanding Family Refusal
The investigators plan a secondary data analysis of an existing dataset to examine how individual decision-making differs from family decision-making in organ donation.
- Trial name
- NCT04303624
- Testing
- Health sciences survey
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Exanimation, Diagnostic Ultrasound
Palpatory and Ultrasonographic Assessment of Tissue Compressibility: Validation and Learning Effects in Phantom Models
This validation study compares clinical palpation and ultrasonographic measurements of tissue compressibility using standardized phantom models.
- Conditions
- Exanimation, Diagnostic Ultrasound, Palpation
- Trial name
- NCT07386782
- Testing
- Ultrasonographic Compression Measurment and Palpation of Standardized Phantom Models
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiac Arrest, Out-Of-Hospital, Angiography
Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma.
In patients with Out-of-Hospital Cardiac arrest who achieves Return Of Spontaneous Circulation (ROSC) The investigators want to evaluate whether there is a benefit from acute Angiography compared to subacute (12-24 hours)…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Angiography, Percutaneous Coronary Intervention, Coma
- Trial name
- DISCO-noCOMA (NCT04876222)
- Testing
- Acute CAG
- Where
- 7 sites in Denmark, Netherlands
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital Skejby
Lesional Coma
Imaging of the Neural Correlates of Arousal and Awareness
In last decades, several advances in the neuro-intensive management have lead to decrease mortality in Intensive Care Units. A significant morbidity remains as patients survive after a traumatic coma with uncertain quality of…
- Trial name
- IMAGINA (NCT04575454)
- Testing
- Multimodal evaluation of brain function : PET-MRI, electrophysiology, eye-tracking
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Consciousness Disorder, Coma
REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness
The aim of this study is to assess the utility of advanced magnetic resonance imaging (MRI) and electroencephalographic (EEG) technologies for predicting functional outcomes in patients with severe traumatic brain injury (TBI).
- Conditions
- Consciousness Disorder, Coma, Brain Injuries, Traumatic
- Trial name
- RESPONSE 2 (NCT03504709)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Coma
Beneficial Effects of Music on Cognition and Consciousness Level
Exposure to music improves cognitive function in 'healthy' participants and in brain-damaged patients. However, it is still difficult to understand what precisely in music causes a positive effect : are they emotional components…
- Trial name
- MUSICOREVEIL (NCT02742506)
- Testing
- Electroencephalography (EEG)
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon