Clinical trials: Exanimation
End of Life, Respiratory Failure
Feasibility of the Comfort Measures Only Time Out (CMOT)
Nearly 25% of Americans die in intensive care units (ICUs). Most deaths in ICUs are expected and involve the removal of ventilator support, or palliative withdrawal of mechanical ventilation (WMV).
- Conditions
- End of Life, Respiratory Failure, Ventilatory Failure, Coma
- Trial name
- NCT05861323
- Testing
- Comfort Measures Only Time out (CMOT)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Beth Israel Deaconess Medical Center
Coma, Cardiac Arrest
Cognitive Auditory Evoked Potential After Cardiac Arrest: Interest of Mismatch negativiTY
Determination of vital and functional outcome in comatose survivors after cardiac arrest is principally based on the identification of predictors of non-awakening, using by clinical, biological and electrophysiological tools.
- Trial name
- CAPACITY (NCT01980446)
- Testing
- Auditory-evoked potentials
- Where
- 2 sites in France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Terminal Illness, End-of-Life Care
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence
Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power…
- Conditions
- Terminal Illness, End-of-Life Care, Death, Brain Death
- Trial name
- NeuroCogPresv (NCT07477028)
- Volunteers
- 20 people
- Sponsor
- Noah Tech, Corp.
Coma
Comparison Between GCS and FOUR Scores
The goal of this observational study is to compare the predictive utility of the Full Outline of Unresponsiveness (FOUR) Score and the Glasgow Coma Scale (GCS) Score in determining outcomes among patients with altered mental…
- Trial name
- GCS/FOUR (NCT06703619)
- Where
- Iraq
- Volunteers
- 240 people
- Sponsor
- Al-Nahrain University
Disorder of Consciousness
Pain Protocol: Nociception Coma Scale-Revised With Personalized Stimulus
The goal of this observational study is to compare Nociception Coma Scale-Revised Recorded (NCS-R) scores obtained with the standard pressure on fingernail bed (standard stimulus, SS) versus other personalized painful stimuli…
- Trial name
- NCT06012357
- Testing
- Nociception Coma Scale-Revised
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Critical Illness, Respiratory Failure
International Observational Study on Airway Management in Critically Ill Patients
Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common.
- Conditions
- Critical Illness, Respiratory Failure, Hemodynamic Instability, Coma
- Trial name
- INTUBE (NCT03616054)
- Where
- Italy
- Volunteers
- 3,600 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Post-Anoxic Coma
Ultrasonic Measurement of the Optic Nerve Sheath Diameter Predicting Outcome After Cardiac Arrest
Rationale: An important proportion of patients with return of spontaneous circulation (ROSC) after cardiac arrest remain comatose as a result of post anoxic encephalopathy (PAE).
- Trial name
- ONSD (NCT04084054)
- Testing
- Ultrasound
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Rijnstate Hospital
Epilepsy, Status Epilepticus
Diagnostic Value of Prehospital EEG in Non-convulsive Status Epilepticus
A large proportion of patients (up to 20%) who suffer from an epileptic seizure and remain unconscious suffer from a non-convulsive epileptic seizure.
- Trial name
- NCT02344706
- Testing
- Registration of EEG
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Chest Trauma
Predictive Value of Chest Trauma Score , Revised Trauma Score , and Glasgow Coma Scale in Patients Presenting With Chest Trauma at Assiut University Emergency Unit.
Thoracic trauma is a critical clinical entity and a major global public health burden, representing the second most frequently occurring unintentional traumatic injury and the third most common cause of death-following head and…
- Trial name
- NCT07812038
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sequelae of; Complications Surgical and Medical Care
The Effect of Listening to the Holy Quran on Vital Signs in Coma Patients
The aim of this study is to examine the effect of the Holy Quran listened to to coma patients on their vital signs. Does listening to the Holy Quran have a positive effect on the life values of coma patients?
- Trial name
- NCT06326541
- Testing
- music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Bitlis Eren University
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury With Loss of Consciousness
Effect of Early Coma Arousal Therapy on Conscious Level Recovery and Cognition in Traumatic Brain Injury
PURPOSE: The aim of this study is to investigate the effect of early coma arousal therapy on conscious level and cognitive function in sever traumatic brain injury patients.
- Trial name
- NCT05521815
- Testing
- Coma arousal therapy, Selected physiotherapy program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Lymph Node Metastases, Gastric Cancer
The Criteria for Lymph Node Sorting for Pathological Examination in Gastric Cancer
The aim of this study is intending to provide the optimal procedures of lymph node sorting for pathological examination after curative surgery for gastric cancer, which can discriminate the differences of the status of lymph node…
- Conditions
- Lymph Node Metastases, Gastric Cancer, Exanimation
- Trial name
- NCT03478449
- Testing
- lymph node sorting for pathological examination
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning
Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial.
- Trial name
- NCT01100515
- Testing
- normobaric oxygen therapy, Hyperbaric oxygen therapy
- Where
- France
- Volunteers
- 179 people
- Sponsor
- University of Versailles
Disorder of Consciousness
Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Disorder of Consciousness
The purpose of this study is to determine if the use of emotional sound as subject own name (SON) pronounced by a familiar voice (FV) compared to SON pronounced by a non-familiar voice (NFV) during event related potential (ERP)…
- Trial name
- ExpressComa (NCT05740735)
- Testing
- Use of "expressive" sounds, Having benefited from a prognostic evaluation by event related potentials (without sound research methods, only neutral sounds)
- Where
- 2 sites in France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI)
Bioavailability of Medium Chain Triglycerides (MCTs) in Comatose Patients With Acute Brain Injury (ABI)
This study will be targeting patients suffering from acute brain injury (ABI), including those with severe trauma brain injury (sTBI) and those with aneurysmal sub arachnoid hemorrhage (aSAH).
- Conditions
- Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI), Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- MCTs and ABI (NCT02716532)
- Testing
- Peptamen AF
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
Disorders of Consciousness, Severe Brain Injury
Effect of Repeated tDCS Sessions on Cognitive Improvement in Patients With Disorders of Consciousness
In this study, researchers will show to caregivers of patients how to use a tDCS device (this device was designed to be easy to use, with fixed parameters and only one button to press to run the stimulation).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients
- Trial name
- rtDCS in DOC (NCT02394691)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University of Liege
Anesthesia, Surgery
Adherence Degree of Kasr-Alaini Hospital Pre-anesthetic Tests to the NICE-UK Guidelines
Routine preoperative tests aim to identify asymptomatic diseases that can't be recognized by history and examination. Identification and management of these diseases is thought to help minimizing perioperative morbidity and…
- Conditions
- Anesthesia, Surgery, Exanimation
- Trial name
- NCT04519268
- Testing
- Adult patients scheduled for an elective general surgical operation.
- Where
- Egypt
- Volunteers
- 185 people
- Sponsor
- Nazmy Edward Seif
Sepsis, Delirium
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive impairment in…
- Conditions
- Sepsis, Delirium, Impaired Cognition
- Trial name
- MENDS2 (NCT01739933)
- Testing
- Dexmedetomidine, Propofol
- Where
- 11 sites in United States
- Volunteers
- 438 people
- Sponsor
- Vanderbilt University Medical Center