Clinical trials: Excision Margin
Caries; Dentin, Dental Restoration Failure of Marginal Integrity
Absence of Liner Following the Selective Caries Removal (ALFSCaRe)
This randomized, multi-centric, controlled clinical trial will assess the effectiveness of a simplified restorative protocol used after the selective carious tissue removal in posterior teeth presenting deep carious lesions.
- Trial name
- (ALFSCaRe) (NCT03933176)
- Testing
- Restoration of carious lesions
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Esophageal Squamous Cell Carcinoma, Positive Circumferential Resection Margin
Adjuvant Radiotherapy for Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin
The purpose of this study is to determine the efficacy of adjuvant radiotherapy for esophageal squamous cell carcinoma with positive circumstantial resection margin.
- Trial name
- NCT03273647
- Testing
- radiation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fudan University
Carcinoma, Basal Cell
Efficiency of Presurgical Basal Cell Carcinoma Margin Mapping
This Interventional Randomised Controlled study is intended to establish that presurgical margin mapping of BCCs with OCT results in a reduction of the number of MMS surgery stages without adversely impacting clinical outcome…
- Trial name
- NCT03420846
- Testing
- OCT Mapped
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Michelson Diagnostics Ltd.
Blepharitis
Lipids of the Human Tear Film and Their Effect on Tear Stability
This prospective, randomized, comparative clinical trial evaluates the effect of either oral doxycycline, oral essential fatty acid, or topical azithromycin to modify the secretions of the meibomian gland in subjects with…
- Trial name
- NCT00803452
- Testing
- doxycycline, azithromycin
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Gingival Recession, Localized
Gingival Response and Marginal Adaptation of Zirconia Crowns With Two Subgingival Margin Designs
The aim of the study is to evaluate the effect of feather edge finish line and deep chamfer finish line on gingival position, bleeding on probing and marginal adaptation.
- Trial name
- NCT04729569
- Testing
- Feather edge finish line preparation, Deep chamfer finish line preparation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Dental Diseases
Bioactive Versus Non-Bioactive Restorative System in Deep Carious Molars
This research study delves into the effectiveness of bioactive and non-bioactive restorative systems in deep carious permanent molars treated with selective caries removal.
- Conditions
- Dental Caries, Dental Diseases, Deep Caries, Tooth Diseases
- Trial name
- NCT06348953
- Testing
- selective caries removal and conventional non-bioactive restorative system, selective caries removal and bioactive restorative system
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontically Treated Teeth, Missing Teeth
Impression & Prosthesis Quality Made From Different Polyvinylsiloxane Impression Techniques
This randomized controlled trial is to clinically assess and compare impression quality of polyvinylsiloxane impression material using one step (experimental) and two step (control) impression techniques and its effect on…
- Conditions
- Endodontically Treated Teeth, Missing Teeth, Discoloration, Tooth, Prosthesis Failure, Dental
- Trial name
- NCT05938400
- Testing
- Polyvinylsiloxane impression with different techniques
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Tumor, Brain, Tumor, Breast
Microscopy Imaging of Whole-mount Stained Human Tissues
The goal of this clinical trial is to develop an imaging platform for intraoperative tumor margin delineation in 250 cases of tumor-suffered patients.
- Conditions
- Tumor, Brain, Tumor, Breast, Tumor Skin
- Trial name
- NCT05689112
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Volunteers, Dynamic Stability Margin
Normative Dynamic & Magnetic Spine
This study aims to describe normal spinal musculoskeletal patterns in healthy adolescents and young adults by using static and dynamic measures.
- Conditions
- Healthy Volunteers, Dynamic Stability Margin, Gait, Paraspinal Muscles
- Trial name
- NDMS (NCT03125434)
- Testing
- EOS full-spine, MRI, gait analysis
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Dental Caries Secondary to Acquired Defects of Tooth Structure
10-years Clinical Trial of Sealed of Margin Failures
Assess the effectiveness of sealing localized marginal defects of amalgam restorations that were initially scheduled for replacement of restorations.
- Trial name
- Sealant (NCT02075801)
- Testing
- Sealing of amalgam margin defects
- Where
- Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Chile
Gingival Recession, Localized
Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
The aim of this randomized, parallel-group clinical trial was to compare the 1-year periodontal, root coverage, esthetic, and patient-centered outcomes of the partial restoration placement with different apical margin levels…
- Trial name
- NCT05682274
- Testing
- Partial restoration approach combined with CAF+CTG
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Blepharitis
Short-term Effects on Tear Film (Baby Shampoo vs Blephasol)
Lid cleansing is the standard regime that is recommended for the management of blepharitis in the UK and beyond. Whilst many successful commercial preparations exist, and some with clinical evidence, professional guidelines (UK…
- Trial name
- Blepha (NCT04858113)
- Testing
- Blephaclean
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Surgical Anastomosis
Intraoperative Hyperspectral Imaging in Gastrointestinal Anastomoses
In this study, gastrointestinal anastomoses are examined with a hyperspectral camera.
- Trial name
- HSIGI (NCT03667950)
- Testing
- Hyperspectral Imaging
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Prosthesis User, Digitalism
"Clinical Evaluation of Retraction Cord Effectiveness Using Intraoral Scanner
Dental-supported fixed partial dentures (FPDs) have long been a commonly preferred treatment method for the rehabilitation of teeth with excessive substance loss and for addressing existing tooth deficiencies.
- Trial name
- NCT06447389
- Testing
- retraction cordu (SURE-CORD®PLUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Plaque
Train New Examiners Via Modified Gingival Margin Plaque
The purpose of this study is to train new examiners while testing two commercial products using our standard one-day brushing study regimen by measuring gingival margin plaque index.
- Trial name
- NCT00758563
- Testing
- Fluoride, Triclosan/Fluoride
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Influence of the Restorative Cervical Margin Placement on the Supracrestal Tissue Attachment
The aim of the present study is to understand the influence that marginal/subgingival restorations exert on the surrounding periodontal tissues.
- Trial name
- NCT04299347
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Siena
Dental Caries
Clinical Performance of Onlay Restorations After Cervical Margin Relocation (CMR)
The current study intends to evaluate the effect of cervical margin relocation with different restorative materials on three-year clinical performance of indirect Computer-Aided-Design (CAD)/ Computer-Aided-Manufacture (CAM)…
- Trial name
- NCT06155773
- Testing
- Highly viscous glass ionomer (cervical margin relocation), Low shrinkage Flowable Composite (cervical margin relocation), Resin Modified Glass Ionomer (cervical margin relocation)
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mansoura University
HepatoCellular Carcinoma
Radiotherapy in Hepatocellular Carcinomas After Hepatectomy With Narrow Margin (<1 cm) or Portal Vein Thrombosis
Hepatocellular carcinoma (HCC) is one of ten leading cancer types worldwide and also in Asia, but the five-year relative survival rate is relatively quite low1-3.
- Trial name
- RHCC (NCT02309788)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Breast Cancer
Margin Optimisation Using Z-axis Assessment With Real-time Tomosynthesis (MOZART Study).
Breast-conserving surgery is commonly performed to remove early-stage breast cancer or ductal carcinoma in situ (DCIS). During surgery, the goal is to completely remove the tumour with a clear margin of normal tissue around it.
- Trial name
- MOZART (NCT07426809)
- Testing
- Standard 2D Specimen Mammography, Mozart 3D Specimen Radiography System
- Where
- Ireland
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Indirect Tooth-colored Onlay Restorations in Posterior Teeth, Clinical Performance of Cervical-margin-relocated Onlay Restorations
Clinical Evaluation of Indirect Tooth-Colored Onlays With Cervical Margin Relocation
This study will evaluate the performance of three different tooth-colored onlay materials in adult patients' posterior teeth. First, investigators will use a bulk-fill composite resin to raise the cavity margin above the gum line…
- Trial name
- NCT07157410
- Testing
- Machinable lithium-disilicate ceramic onlay (IPS e.max CAD), Pressed lithium-disilicate ceramic onlay (IPS e.max Press), Machinable composite onlay (BRILLIANT Crios)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mansoura University