Clinical trials: Excision Margin
Gingival Recession, Periodontal Atrophy
Comparison Between Two Coronally Positioned Flap With Connective Tissue
The aim of this study is to evaluate the effectiveness of total root coverage between two coronally positioned flap technique in Miller recession Class I and II, in patients attending at "Universidad El Bosque" dental school…
- Trial name
- NCT01814592
- Testing
- coronally partial thickness flap plus connective tissue, coronally mucosal thickness flap
- Where
- Colombia
- Volunteers
- 72 people
- Sponsor
- Universidad El Bosque, Bogotá
Pancreatic Neoplasms
SBRT Pre-operatively for Pancreatic Cancer
In this study the investigators are testing if the addition of Stereotactic Body Radiation therapy (SBRT) prior to surgery improves surgical outcome in patients with borderline resectable or resectable pancreatic cancer (BRPC).
- Trial name
- SPARC (NCT02308722)
- Testing
- 5-fraction stereotactic body radiation therapy
- Where
- 5 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Oxford
Basal Cell Carcinoma of Skin
AI-enhanced OCT Imaging for Pre-surgical Margin Detection of Basal Cell Carcinoma
Basal cell carcinomas (BCCs) are the most common human malignancy, affecting about 2 million Americans each year. Mohs micrographic surgery (MMS) removes tissue by sequential excision.
- Trial name
- NCT07358637
- Testing
- AI-OCT
- Volunteers
- 30 people
- Sponsor
- Henry Ford Health System
HCC - Hepatocellular Carcinoma
Defining the Ablative Dose for Y-90 TARE
This study is being done to help doctors improve how they treat liver tumors that cannot be removed by surgery or treated with standard ablation techniques.
- Trial name
- MARGIN (NCT07586046)
- Testing
- Yttrium-90 Radiation Segmentectomy (Y90 RS) using glass microspheres
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Breast Cancer, Sentinel Lymph Node
Trop2-targeting NIR-II Molecular Probe for Breast Cancer Precise Surgery
Positive surgical margins are closely associated with local recurrence in breast-conserving surgery (BCS). Meanwhile, accurately assessing sentinel lymph node (SLN) metastasis is crucial for determining the extent of axillary…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Margins of Excision
- Trial name
- NIR-II (NCT06713681)
- Testing
- TTP-ICG incubation solution
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Yunnan Cancer Hospital
Lentigo Maligna
Radiotherapy or Imiquimod in Complex Lentigo Maligna
The purpose of this study is to investigate the effectiveness of using either radiotherapy (RT) or Imiquimod (ImiQ) to treat the Lentigo Maligna (LM), when surgery is not possible, is refused, or fails.
- Trial name
- RADICAL (NCT02394132)
- Testing
- Imiquimod, Radiotherapy
- Where
- 10 sites in Australia, Brazil and 1 more
- Volunteers
- 126 people
- Sponsor
- Melanoma and Skin Cancer Trials Limited
Bladder Cancer, Bladder Urothelial Carcinoma
Bladder Perforation Post-TURBT: Definition, Incidence and Natural HistoryStudy
In view of sparse data of precise definition, risk factors, natural history and management of bladder perforation following Transurethral resection of bladder tumour (TURBT).
- Conditions
- Bladder Cancer, Bladder Urothelial Carcinoma, Trauma, Injuries
- Trial name
- TURBT-BP (NCT04129606)
- Testing
- Computed tomographic cystography
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Abdelwahab Hashem
Adenocarcinoma of the Rectum, Adenocarcinoma
Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks
The aim of this study is to determine whether greater rectal cancer downstaging and regression occurs when surgery is delayed to 12 weeks after completion of radiotherapy/chemotherapy compared to 6 weeks.
- Conditions
- Adenocarcinoma of the Rectum, Adenocarcinoma, Adenocarcinoma, Mucinous, Carcinoma
- Trial name
- NCT01037049
- Testing
- Patients who have surgery at 12 weeks after radiotherapy/chemoradiotherapy
- Where
- 23 sites in Brazil, Canada and 2 more
- Volunteers
- 237 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Stage II Rectal Cancer, Stage III Rectal Cancer
Quicksilver II Pilot Study
This pilot study is being done to answer the following question: Will patients with margin-clear Stage 2 or 3 rectal cancer who don't require a colostomy agree to be randomized to 'surgery only' or 'chemotherapy and then…
- Trial name
- NCT07688135
- Testing
- Direct-to-surgery (i.e., no neoadjuvant chemotherapy), Control Group
- Volunteers
- 18 people
- Sponsor
- Mount Sinai Hospital, Canada
Breast Cancer
Study to Evaluate Surgical Excision Margins in Malignant Breast Lumpectomies With the PEAK PlasmaBlade
The purpose of this research study is to find out more about distinguishing between cancerous and non-cancerous breast cancer cells at the edges of tumors.
- Trial name
- NCT00972010
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sarah Blair, M.D.
Breast Cancer
Fast Spectral Imaging Device for Tumor Margin Mapping
The objective of the proposed research is to develop a clinical-trial-ready device and to evaluate its practical utility as a routinely used intra-operative tool.
- Trial name
- NCT01107080
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Duke University
Breast Cancer
A Prospective Clinical Study Investigating the Use of the Histolog Scanner for Intraoperative Assessment of Surgical Margins in Patients Undergoing Breast-conserving Surgery for Histologically Confirmed Breast Cancer. The Histolog Scanner Operates on the Principle of Confocal Microscop
A prospective clinical study investigating the use of the Histolog Scanner for intraoperative assessment of surgical margins in patients undergoing breast-conserving surgery for histologically confirmed breast cancer.
- Trial name
- NCT07341542
- Testing
- Histolog scanner
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Silesian Hospital in Opava
Melanoma
Impact of Excision Margins on Survival and Recurrence Rate in Patients With Thick Melanoma (>2mm)
Objective: To investigated the impact of the excision of melanoma 2mm≤ in thickness with 1cm surgical margins on survival of the patients compared with 2 cm surgical margins.
- Trial name
- NCT02088762
- Testing
- surgical excision
- Where
- Switzerland
- Volunteers
- 325 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
BCC - Basal Cell Carcinoma, BCC
CellFX Treat & Resect Low-Risk BCC Feasibility Study
This prospective, multicenter, study is designed to evaluate the safety and effectiveness of the CellFX System in adults subjects with low-risk basal cell carcinoma (superficial and nodular) for complete histological clearance of…
- Conditions
- BCC - Basal Cell Carcinoma, BCC, Excision Margin
- Trial name
- NCT04918381
- Testing
- CellFX System
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pulse Biosciences, Inc.
Breast Cancer
Preoperative Magnetic Resonance Imaging to Obtain Adequate Resection Margins in Breast Conserving Surgery, (PRIMAR) Trial
The goal of this randomised study is to investigate if a supplementary preoperative breast Magnetic Resonance Imaging (MRI) improves the assessment of breast cancer and can help surgical planning such that sufficient resection…
- Trial name
- PRIMAR (NCT05825768)
- Testing
- Breast MRI, standard breast imaging
- Where
- 2 sites in Denmark
- Volunteers
- 227 people
- Sponsor
- Aarhus University Hospital
Prostate Cancer
Microendoscopic EI Sensing for Real-time Intraoperative Surgical Margin Assessment
This research will study a custom device developed to detect if any prostate cancer tissue is left behind when the prostate is removed. This device is called an Electrical Impedance Imaging (EII) probe.
- Trial name
- RARP EI (NCT06039085)
- Testing
- custom device to demonstrate a significant difference in electrical impedance signatures
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ryan J. Halter
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Cellular-Level Fluorescence Imaging for Intraoperative Margin Assessment in Breast Cancer
Accurate intraoperative margin assessment in breast cancer surgery remains challenging. Current reliance on frozen section pathology is limited by prolonged processing time, sampling constraints, and resource intensity…
- Trial name
- FLASH (NCT07311317)
- Where
- 3 sites in China
- Volunteers
- 165 people
- Sponsor
- West China Hospital
Breast Cancer
Intraoperative Detection of Breast Cancer by Electrosurgical Gas Analysis and Artificial Intelligence
The aim of this clinical trial is to assess the feasibility of training a device capable of distinguishing various gases emitted by tissues cauterized by an electrosurgical unit during a breast cancer resection surgery.
- Trial name
- NCT07131735
- Where
- 2 sites in Chile
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Prostate Cancer Surgery, Head and Neck Cancers
Investigating the Diagnostic Performance of High-resolution Specimen PET-CT in Determining Margin Status in Cancer Resection
Surgical removal is the treatment for many different cancers. Patient outcomes depend on complete cancer removal with no tumour present at the edge of the section removed (specimen).
- Trial name
- eXcision (NCT06676943)
- Testing
- XEOS AURA 10 specimen PET-CT scan of tumour specimens
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Cervical Intraepithelial Neoplasia
A Trial of Two Electrosurgical Conizations: Histopathological Analysis of Excision Margins
The purpose of this trial is to evaluate if Straight Wire Excision of the Transformation Zone (SWETZ) is superior to (Large Loop Excision of the Transformation Zone) LLETZ cone in reducing the incomplete excision of disease.
- Trial name
- NCT01929993
- Testing
- SWETZ, LLETZ cone
- Where
- Brazil
- Volunteers
- 164 people
- Sponsor
- Oswaldo Cruz Foundation