Clinical trials: Executive Function Disorders
Autism Spectrum Disorder, High-functioning Autism
An Intervention Targeting Daily Adaptive Skills Through Executive Function Training for Adults With ASD
The current study is a single group pilot study of a novel intervention program which targets improvements in executive functions and adaptive skills in transition age young adults with high-functioning autism spectrum disorder.
- Conditions
- Autism Spectrum Disorder, High-functioning Autism, Autism
- Trial name
- NCT04418492
- Testing
- Skills for Adaptive Functioning through Executive training (SAFE; tentative title)
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Seoul National University Hospital
ADHD, Executive Function Deficits (EFD's)
Memantine Monotherapy for Executive Dysfunction and ADHD
This is a 12-week clinical trial evaluating the efficacy and safety of memantine hydrochloride (Memantine HC1, brand name Namenda) in the treatment of executive function deficits (EFDs) in adults with Attention Deficit…
- Trial name
- NCT01844427
- Testing
- Memantine
- Sponsor
- Massachusetts General Hospital
Child Development, Early Child Development
Intergenerational Risk and Resilience of Rohingya in Displacement
The iRRRd study is an ongoing prospective longitudinal prenatal birth cohort study based in Cox's Bazar, Bangladesh. Between February 2023 and March 2024, 2,888 pregnant women were enrolled (approximately 80% Rohingya refugees…
- Conditions
- Child Development, Early Child Development, Mental Health, PTSD - Post Traumatic Stress Disorder
- Trial name
- iRRRd (NCT07758283)
- Where
- Bangladesh
- Volunteers
- 2,200 people
- Sponsor
- New York University
Alcohol Use Disorder (AUD)
Evaluation of a Virtual Reality-based Version of the Multiple Errands Test in Alcohol Use Disorder
The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD). More specifically, the project aims to: 1.
- Trial name
- EVIMETAL (NCT07593664)
- Testing
- Multiple Errand Test (MET), Virtual MET
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Breast Cancer
Assessment of Sensory Gating, Attention, and Executive Control in Breast Cancer
This study is being done to find out if a new series of evaluations called the SAE (Sensory-Attention-Executive) Battery can help researchers learn more about how cancer treatment does or does not change the way the brain…
- Trial name
- NCT03619083
- Testing
- SAE battery, Assessments
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Traumatic Brain Injury, Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive…
- Conditions
- Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT04296604
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Executive Function Deficits (EFD), Developmental Coordination Disorder
Let's CO-OPerate! Together we Are Stronger
The goal of this replicated single case experimental study using a randomized multiple baseline design across participants and goals is to enable children/adolescents (aged 8-16 years) with developmental coordination disorders…
- Conditions
- Executive Function Deficits (EFD), Developmental Coordination Disorder, Acquired Brain Injury (Including Stroke), Brain Injury, Fetus and Neonate
- Trial name
- NCT07085403
- Testing
- Cognitive Orientation to daily Occupational Performance (CO-OP) is a cognitive problem-solving approach
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Internet Addiction Disorder
Examining of Occupational Balance, Executive Functions, and Quality of Life of Adolescents with Internet Gaming Disorder
Internet gaming disorder leads to social problems and isolation, neglect of daily responsibilities, behavioral disorders, and cognitive and physical impairments.
- Trial name
- NCT06497166
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Traumatic Brain Injury
Improving Executive Functioning After Traumatic Brain Injury (TBI): A Trial of the "Short Term Executive Plus" Program
The purpose of this study is to determine the efficacy of an intensive short term cognitive rehabilitation program aimed towards improving executive functioning in individuals with traumatic brain injury (TBI).
- Trial name
- STEP (NCT00627237)
- Testing
- Immediate Start, Waitlist
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Metastatic Brain Tumor, Cerebral Metastases
Impact of Cognitive Rehab and Physical Activity on Cognition in Patients With Metastatic Brain Tumors Undergoing RT
To determine the feasibility of processes and instruments with an overarching purpose to guide the design of a larger study. To determine the feasibility of individuals with metastatic brain tumor(s) to engage in physical…
- Trial name
- NCT03096431
- Testing
- Physical Activity, Cognitive rehabilitation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Autism Spectrum Disorder, Attention Deficit-Hyperactivity Disorder
Community Based Intervention for Children With ADHD and ASD
The purpose of this study is to determine whether a new treatment, Unstuck and On Target (UOT), works better, worse, or the same as the best treatment that is available now, Contingency Behavioral Management (CBM), for low income…
- Conditions
- Autism Spectrum Disorder, Attention Deficit-Hyperactivity Disorder, Executive Function
- Trial name
- NCT03003286
- Testing
- Unstuck and on Target (UOT), Parents and Teachers Supporting Students (PATSS)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Lauren Kenworthy
Parkinson Disease, Mild Cognitive Impairment
Goal Management Training for Parkinson Disease Mild Cognitive Impairment
Mild cognitive impairment is experienced by approximately 30% of patients with Parkinson's disease (PD-MCI), often affecting executive functions.
- Trial name
- NCT04636541
- Testing
- Goal Management Training, Psychoeducation
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Laval University
Parkinson Disease (PD)
Inhibitory Control and Gait Adaptability in Parkinson's Disease
People with Parkinson's disease (PD) may have difficulty stopping or changing their movements, especially when walking around obstacles.
- Trial name
- NCT07494461
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Type 2 Diabetes Mellitus (T2DM), Cognitive Dysfunction
SGLT2 Inhibitors and Cognitive Function in Adults With Type 2 Diabetes (SaveMinD)
This study is a prospective, randomized, open-label trial with blinded outcome assessment (PROBE design) designed to evaluate the effects of sodium-glucose cotransporter-2 (SGLT2) inhibitor therapy on cognitive function in adults…
- Trial name
- SaveMinD (NCT07694596)
- Testing
- SGLT2 Inhibitor, Standard Diabetes Care
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University of Primorska
Obstructive Sleep Apnea
Obstructive Sleep Apnea Syndrome and Attention Executive Function Disturbances
Studies demonstrate that sleep disturbances are associated with cognitive dysfunction and attention deficit. However the correlation between the severity of obstructive sleep apnea and the degree of cognitive dysfunction was not…
- Trial name
- NCT00757796
- Volunteers
- 80 people
- Sponsor
- Assaf-Harofeh Medical Center
Type 1 Diabetes, Adherence, Patient
Diabetes Journey: An Adolescent Adherence Barriers Intervention
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a web-based intervention addressing adherence barriers in adolescents with T1D.
- Trial name
- NCT04404556
- Testing
- Diabetes Journey, Enhanced Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 195 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bipolar Disorder
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder
Transcranial light therapy, or transcranial photobiomodulation (tPBM), is a treatment that stimulates the brain by applying near-infrared light to the forehead.
- Trial name
- TPEB (NCT05408637)
- Testing
- Transcranial Phoobiomodulation (tPBM)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Paolo Cassano
Chronic Widespread Pain, Sleep Disturbance
Sleep Disturbances and Chronic Widespread Pain
Chronic widespread pain (CWP), defined as long-lasting pain in multiple body regions, has a prevalence of 10-14% in Europe and is associated with other physical symptoms such as fatigue and cognitive problems.
- Trial name
- POSEIDON (NCT03908905)
- Testing
- Polysomnography
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Uppsala University
Insulin Growth Factor I Deficiency, IGF1 Deficiency
Effect of a HIIT Program on Quality of Life, Executive Functions, and IGF-1 Response in Sedentary Young University Women
Sedentary lifestyle, understood as an activity that requires minimal body movement (Tremblay et al., 2017), is one of the main factors responsible for chronic diseases in Young adults.
- Conditions
- Insulin Growth Factor I Deficiency, IGF1 Deficiency, Executive Function Disorder
- Trial name
- NCT05642169
- Testing
- HIIT, HIIT+PA, CON
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Seville