Clinical trials: Executive Function Disorders
Cognitive Impairment, Estrogen Deficiency
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
Complaints about memory and thinking are common in women as they go through menopause. The female hormone estrogen is important for both the health of both the brain and the blood vessels.
- Conditions
- Cognitive Impairment, Estrogen Deficiency, Menopause, Endothelial Dysfunction
- Trial name
- NCT03112226
- Testing
- GnRHant + E2
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy, Cognitive Function 1, Social
Active Gains in Brain Using Exercise During Aging
AGUEDA (Active Gains in brain using Exercise During Aging) is a randomized controlled trial designed to examine the effects of a 24-week resistance exercise program on brain health in cognitively normal adults between 65-80 years…
- Trial name
- AGUEDA (NCT05186090)
- Testing
- 24-week resistance exercise program
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Spinal Cord Injury
Magnetic Resonance Imaging of Cognitive Deficits in the Brain of Individuals With Spinal Cord Injury
In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date.
- Trial name
- SCI_Cog (NCT06309888)
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Reading Disability
Executive Function in Early Childhood
Despite the fact that a substantial number of school age children struggle with both reading and math acquisition, the brain mechanisms of the overlapping aspects of reading and math skills, thought in part to be linked via…
- Trial name
- NCT03713125
- Testing
- Reading Tutoring
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Parkinson's Disease
The Effect of Rasagiline on Cognition in Parkinson's Disease
While Parkinson's disease has historically been defined in terms of its motor symptomatology, studies have shown that non-motor deficits form an important part of the syndrome.
- Trial name
- NCT01382342
- Testing
- Rasagiline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brown University
Acquired Brain Injury
Exploring the Use of the CO-OP With Children With EF Functions Deficits Following ABI
Purpose: Acquired brain injury (ABI) in childhood are the cause of disabling motor, cognitive and behavioural disorders, with severe consequences on the later development of autonomy and learning, with long-term repercussions on…
- Trial name
- NCT04718688
- Testing
- CO-OP rehabilitation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Hopitaux de Saint-Maurice
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
ADHD
Amiloride Hydrochloride as an Effective Treatment for ADHD
The investigators are proposing to test a medication derived from our prior studies of the gene SLC9A9. This one gene makes NHE proteins that control how we learn and remember items, which is impaired in ADHD and may cause an…
- Trial name
- NCT01733680
- Testing
- amiloride, Behavioral
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- State University of New York - Upstate Medical University
Acquired Brain Injury, Executive Dysfunction
A Single-case Design to Investigate a Compensatory Strategy Game Supporting Goal Management Training
The main cognitive complaint in brain-injured patients is often the everyday disorganization caused by executive function (EF) deficits. In order to minimize the everyday disorganization, effective EF interventions are required.
- Conditions
- Acquired Brain Injury, Executive Dysfunction, Goal Management Training, Compensatory Strategy Training
- Trial name
- NCT05737238
- Testing
- Intervention during phase B: Compensatory brain game supporting Goal Management Training intervention
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Klimmendaal Revalidatiespecialisten
Autism Spectrum Disorder
Effects of Systematic Exercise Training on Core Symptoms, Executive Function and Brain Function in Children With ASD
Studies have shown that children with ASD simultaneously have deficits in overall executive function and impairments in basic motor skills, which have a negative impact on cognitive and social all-round development.
- Trial name
- NCT07104708
- Testing
- The Child-Parent- Trainer exercise program, The regular physical training
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chen Li
Cognition, Mood
Genistein, Equol, Cognitive Function and Mood: Twelve-week. (GECFAMc)
Isoflavones (ISF) are naturally occurring compounds that can provide protective benefits for certain domains of cognitive function.
- Trial name
- GECFAMc (NCT07742501)
- Testing
- Equol, Genistein, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Reading
Anxiety, Cognitive Deficit
Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits
This study investigates the potential of cranial electrotherapy stimulation to mitigate anxiety induced cognitive deficits
- Trial name
- NCT04961112
- Testing
- Cranial Electrotherapy Stimulation
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Tufts University
Child Obesity, Social Determinants of Health
Addressing Social Determinants of Health in Child Obesity Treatment Using Community Health Workers
The goal of this small pilot study is to test the feasibility of combining a three-month intervention of working with a community health worker (CHW) to address social risk factors for patients prior to beginning a group weight…
- Trial name
- NCT06520657
- Testing
- Community Health Worker, Child weight management intervention, Standard of Care referral to resources
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Mercy Hospital Kansas City
Refractory Schizophrenia
Occupational Therapy in the Rehabilitation of Executive Functions in Patients With Schizophrenia
Primary Objective: Efficacy of Occupational Therapy (OT) based Occupational Goal Intervention (OGI) in improving executive functions in patients with refractory schizophrenia as measured by the BADS.
- Trial name
- OTSchizo (NCT01879956)
- Testing
- Craft Activities, OGI Method
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Suicidal Ideation
Improving Caregivers' Ability to Manage Life Stress
The COVID-19 pandemic has led to increased caregiving demands for caregivers of Veterans with dementia. Dementia caregivers are particularly at-risk for depression and anxiety, known risk factors for increased suicidality.
- Trial name
- NCT05539352
- Testing
- Problem Solving Therapy (PST) plus EUC
- Where
- United States
- Sponsor
- VA Office of Research and Development
Anxiety, PTSD
Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health
RESYNC-BH is a research study evaluating a personalized, non-drug brain-and-body treatment approach for adults with ongoing behavioral health symptoms such as depression, anxiety, trauma-related symptoms, sleep problems…
- Conditions
- Anxiety, PTSD, ADHD, Depression Disorders
- Trial name
- RESYNC-BH (NCT07812987)
- Testing
- AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Tactical Mind Research Coalition, Inc.
Obsessive Compulsive Disorder
Treatment Youth With Obsessive-Compulsive Disorder
Although research suggests that patients with obsessive-compulsive disorder (OCD) exhibit specific deficits in their high cognitive processes, it is still unknown how these deficits relate to the clinical symptoms of the…
- Trial name
- NCT00708240
- Testing
- Escitalopram
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Healthy Aging, Alzheimer's Disease (AD)
Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk.
- Trial name
- MUST (NCT06995638)
- Testing
- Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
ADHD
Effects of an Aerobic Exercise Intervention on Core Symptoms, Executive Functioning, and Quality of Life in Children With Attention Deficit Hyperactivity Disorder
Selecting a maternal and child healthcare hospital in Shenzhen City, Guangdong Province, 50 cases of ADHD children as the study subjects, according to the inclusion and exclusion criteria to screen the eligible study subjects…
- Trial name
- NCT06553430
- Testing
- aerobics exercises
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Harbin Medical University