Clinical trials: Executive Function Disorders
Traumatic Brain Injury
Virtual Reality in Rehabilitation of Executive Functions in Children With Mild or Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) causes lifelong disability. Children with TBI often have difficulties in attention regulation and executive functions affecting their daily living.
- Trial name
- VREALFUN-TBI (NCT06127459)
- Testing
- Parental Guidance, Virtual Reality Game
- Where
- Finland
- Volunteers
- 44 people
- Sponsor
- Merja Nikula
ADHD, Cognitive Deficit
Cognitive Intervention in Attention Deficit and Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder is a disorder in which children show insufficient attention span, hyperactivity and impulsivity according to their developmental level.
- Trial name
- NCT05063669
- Testing
- Cognitive Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Biruni University
Schizophrenia, Schizoaffective Disorder
Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) Study
The goal of this study is to use transcranial magnetic stimulation (TMS) to investigate the impact of modulating cerebellar activity on time perception, executive function, and mood and psychotic symptoms in psychosis patients…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder I
- Trial name
- NCT02642029
- Testing
- Excitatory TMS, Inhibitory TMS
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Specific Learning Disability, Mental Health Issue
Biopsychosocial Outcomes of Mindfulness-based Instruction
Over 20% of adolescents living in the United States have a diagnosable psychiatric disorder. However, most adolescents who need mental health services do not receive them due to many reasons, including low resources in families…
- Trial name
- MindUP (NCT05787483)
- Testing
- MindUP group, active control group
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease, Executive Function
Effects of STN DBS on Cognition and Brain Networks in PD Patients Analyzed Based on EEG and fNIRS
In recent years, deep brain stimulation (DBS) has become the primary treatment for patients with medically uncontrolled Parkinson's disease (PD).
- Conditions
- Parkinson's Disease, Executive Function, Electroencephalogram, Functional Near - Infrared Spectroscopy
- Trial name
- NCT06175897
- Testing
- Deep Brain Stimulation, non-Deep Brain Stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhiqi Mao
Alcohol Use Disorder Cognitive Decline
NEUROPSYCHOLOGICAL REHABILITATION FOR ALCOHOL USE DISORDERS
This investigation will take place between September 2024 and June 2025, with the objective of analyzing executive deficits and the impact of Neuropsychological Rehabilitation on Alcohol Use Disorder, comparing different…
- Trial name
- AUD (NCT06933186)
- Testing
- Neuropsychological rehabilitation, Weekly therapeutic groups
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
Tobacco Use, Cigarette Smoking
RTMS Targets Neural Circuits for Smoking Cessation
Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel…
- Trial name
- NCT04903028
- Testing
- Active rTMS 10 Hz DLPFC
- Where
- 2 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Primary Brain Tumor
Neurocognitive Function After Proton Therapy in Children and Adolescents
Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in…
- Trial name
- ELBE-ProKids (NCT04066465)
- Where
- 3 sites in Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Dementia
Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population
Dementia is a prevalent condition with no known cure. It affects not only the person with dementia but also the family. This study will investigate the effects of applying different transcranial electrical stimulation (tES)…
- Trial name
- NCT06547021
- Testing
- Transcranial Direct Current Stimulation (tDCS), Gamma Transcranial Alternating Current Stimulation (tACS), Theta Transcranial Alternating Current Stimulation (tACS)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Manitoba
Cocaine Use Disorder
Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
The proposed work will investigate changes in brain signaling and cognitive functioning that support recovery from addiction, as well as use of pretreatment neurocognitive functioning to inform substance use treatment planning.
- Trial name
- WRAP (NCT03799341)
- Testing
- Prize-Based Contingency Management, Treatment As Usual Outpatient Substance Use Treatment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Attention Deficit Hyperactivity Disorder
Intensive Executive Function Training
The investigators intent to recruit 80 attention deficit hyperactivity disorder families. The attention deficit hyperactivity disorder families had received executive function training one year before.They will be randomized to…
- Trial name
- NCT02656758
- Testing
- intensive Executive function training
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- ZIli Fan
Stroke, Ischemic
Cognitive Strategies for Optimizing Brain Health And Managing Transgenerational Vascular Risk Factors Post-Stroke
People living with the cognitive effects of stroke are at risk for recurrent stroke and further cognitive decline. Also problematic is that stroke risk clusters in families and biological family members of people who have…
- Trial name
- CHAMPS-TR (NCT06479174)
- Testing
- CHAMPS-TR
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Cognitive Decline, Executive Dysfunction
Fitness on White Matter and Cognition in Aging
Cardiorespiratory fitness (CRF) is associated with decreased risk for mild cognitive impairment (MCI) and dementia. CRF is linked with more conserved gray and white matter (WM) volume, improved WM microstructural integrity, and…
- Conditions
- Cognitive Decline, Executive Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03775941
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Suffolk University
Musculoskeletal Pain, Cognitive Change
Health, Wellbeing and Performance in Law Enforcement Workers
This study aims to assess current health and fitness of law enforcement workers in various roles, and to evaluate the impact of an exercise intervention on markers on physical and mental wellbeing in this population.
- Conditions
- Musculoskeletal Pain, Cognitive Change, Occupational Stress, Inflammation
- Trial name
- NCT04204486
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London
Attention Deficit Hyperactivity Disorder
Metabolic Pathway of Tryptophan and Executive Dysfunction in Children With Attention Deficit Hyperactivity Disorder
The present project is to identify the relationship between ADHD and the metabolites of tryptophan.
- Trial name
- NCT03901859
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Major Depressive Disorder
SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder
To evaluate the efficacy of SPD489 for the treatment of executive function impairments (EFI) when used as an adjunct to stable, standard therapy in the setting of partial or full remission from recurrent Major Depressive Disorder…
- Trial name
- NCT00985725
- Testing
- SPD489 (Lisdexamfetamine dimesylate)
- Where
- 33 sites in United States
- Volunteers
- 143 people
- Sponsor
- Shire
Parkinson's Disease, Exercise Therapy
Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease
Parkinson's disease (PD) is a difficult to treat condition that impairs mobility and thinking. It is not fully treated by drugs and surgery. Two priority issues for most people with PD are "OFF-time" and Cognitive impairment.
- Conditions
- Parkinson's Disease, Exercise Therapy, Cognition
- Trial name
- PDAE in PD (NCT04122690)
- Testing
- PDAE, WAE
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
Reading Disability
Executive Function in Early Childhood
Despite the fact that a substantial number of school age children struggle with both reading and math acquisition, the brain mechanisms of the overlapping aspects of reading and math skills, thought in part to be linked via…
- Trial name
- NCT03713125
- Testing
- Reading Tutoring
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Substance Dependence, Executive Function Disorder
Brain Mechanism and Intervention of Executive-control Dysfunction Among Substance Dependents
The investigators assume that tACS could improve amphetamine and alcohol dependent patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral…
- Conditions
- Substance Dependence, Executive Function Disorder, Transcranial Alternating Current Stimulation
- Trial name
- NCT05312359
- Testing
- Transcranial alternating current stimulation-true stimulus
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center