Clinical trials: Exercise Tolerance
Congestive Heart Failure
Study of Sildenafil in Advanced Heart Failure.
Despite advances in medical therapy for patients with heart failure, one-third of patients remain limited by fatigue and shortness of breath.
- Trial name
- NCT00309790
- Testing
- sildenafil
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
PCOS
Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin…
- Trial name
- NCT06155708
- Testing
- Ketone, Water
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Resistance Training for the Improvement of Glycemic Control in Prediabetes
The purpose of this research is to study the effects of resistance exercise training with different degrees of effort on your glucose responses (what we call glycemic control) and psychological responses.
- Trial name
- NCT06697756
- Testing
- High-effort resistance exercise training, Low-effort resistance exercise training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of New Mexico
Heart Failure With Reduced Ejection Fraction, Chronic Heart Failure
Vericiguat and Exercise Hemodynamics in Patients With HFrEF
Heart failure with reduced ejection fraction (HFrEF) is associated with impaired exercise capacity and abnormal exercise hemodynamics despite contemporary guideline-directed medical therapy (GDMT).
- Trial name
- EVERHETT-HF (NCT07697365)
- Testing
- Vericiguat, Guideline-directed medical therapy (GDMT) for heart failure
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Argyrios Ntalianis
Chronic Respiratory Failure, Hypoxemia
Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia
The aim of this multicenter crossover trial is to describe the effect of adding a therapeutic dose of exertional oxygen therapy, in terms of exercise performance, gas exchange, heart rate, symptoms perception and subjective…
- Conditions
- Chronic Respiratory Failure, Hypoxemia, Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease
- Trial name
- NCT07451977
- Testing
- Usual Oxygen During 6-Minute Walk Test, Supplemental Oxygen During 6-Minute Walk Test
- Where
- 6 sites in Italy
- Volunteers
- 114 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Axial Spondyloarthritis (AxSpA)
Multimodal Pulmonary Rehabilitation in Radiographic Axial Spondyloarthritis
This prospective pilot study aims to evaluate the efficacy of a structured 8-week multimodal pulmonary rehabilitation (PR) program specifically designed for patients with radiographic axial spondyloarthritis (r-axSpA).
- Trial name
- PuRe-axSpA (NCT07430189)
- Testing
- Multimodal Pulmonary Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Balikesir University
Overweight and Obesity
The Effect of Exercise and/or Diet on Health Related Parameters
The study evaluates the effect of exercise and/or diet during on body weight, body composition and health related blood parameters.
- Trial name
- NCT04100356
- Testing
- Exercise, Normal Diet, LCHF Diet
- Where
- Norway
- Volunteers
- 57 people
- Sponsor
- Atlantis Medical University College
Type 2 Diabetes
Application and Effectiveness Analysis of Internet-based Diabetes Prevention Program
This study was conducted to test the possibility of preventing or delaying the development of type 2 diabetes in individuals with impaired glucose tolerance and elevated fasting plasma glucose concentrations by internet-based…
- Trial name
- NCT01085682
- Testing
- Lifestyle counseling, Standard care
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
COPD (Chronic Obstructive Pulmonary Disease)
Inhaled Treprostinil for Dyspnea and Exercise Intolerance in Mild COPD
The goal of this clinical trial is to evaluate the impact of inhaled Treprostinil on breathlessness and low exercise capacity in patients living with mild chronic obstructive pulmonary disease.
- Trial name
- NCT06969573
- Testing
- Treprostinil Inhalation Solution 36 mcg, Treprostinil Inhalation Solution 78 mcg
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Iron-deficiency, Heart Failure
Effect of IV Iron in Patients With Heart Failure With Preserved Ejection Fraction
This study addresses, whether treatment with IV iron for patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency (ID), both with or without anaemia, can improve exercise capacity as measured by…
- Trial name
- FAIR-HFpEF (NCT03074591)
- Testing
- Ferric Carboxymaltose 50Mg/Ml Inj 15Ml, Saline Solution for Injection
- Where
- 7 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
End Stage Liver Disease
Evaluation of Frailty and Functional Capacity in End-Stage Liver Disease
Development of fibrosis plays a main role in the pathophysiology of liver diseases. The rate of progression in fibrogenesis varies according to the type of underlying liver disease and varies with the environment and host-related…
- Trial name
- NCT04220723
- Testing
- Frailty Assessment, Functional Capacity Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hypoxia, Altitude Sickness
Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely
This project will consist of two studies, each investigating resting and exercise cardio-respiratory responses during exposure to hypoxia in individuals born prematurely and individuals born at full term of two different age…
- Conditions
- Hypoxia, Altitude Sickness, Tolerance
- Trial name
- PreTerm (NCT02780908)
- Testing
- Graded exercise testing, Resting testing
- Where
- 2 sites in Slovenia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Angina
Effect of Febuxostat Compared to Placebo on Exercise Tolerance in Participants With Chronic Stable Angina
The purpose of this study is to evaluate the effect of febuxostat, once daily (QD), compared to placebo as an add on to stable anti-anginal therapy, on the total exercise time of participants with Chronic Stable Angina.
- Trial name
- NCT01549977
- Testing
- Febuxostat
- Where
- 21 sites in United States
- Volunteers
- 1 people
- Sponsor
- Takeda
Cystic Fibrosis (CF), Primary Ciliary Dyskinesia (PCD)
Exercise Capacity, Muscle Oxygenation, Respiratory Muscle Strength, and Physical Activity Level in Pediatric CF and PCD
Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are genetic diseases characterized by chronic respiratory tract infections.
- Trial name
- NCT07157644
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Gazi University
Heat Stress, Heat
Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise
Military personnel are called upon to serve in hot, dry or humid climates, which places great demands on their ability to tolerate heat. Induced heat stress can impair performance and lead to pathologies.
- Trial name
- PENTHERE (NCT05921864)
- Testing
- Passive heat exposure, Active heat exposure
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Arterial Hypertension, Heart Failure
Factors and Prognostic Significance of Impaired Exercise Tolerance in Women Over 40 With Arterial Hypertension
The subject of the study is evaluation of factors affecting to exercise intolerance in spiroergometry in women over 40 years of age with hypertension and association and relationship between the parameters of physical performance…
- Trial name
- NCT04802369
- Testing
- Diagnostic tests
- Where
- Poland
- Volunteers
- 185 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
End Stage Renal Disease on Dialysis, Hemodialysis Complication
Virtual Reality Intradialysis: Last vs. First Part of the Session
The main objective of this investigation is to assess if an intradialysis virtual reality exercise program during the last two hours of the hemodialysis session results in greater hemodynamic stability than exercise performed…
- Trial name
- VRI (NCT04046042)
- Testing
- Conventional exercise, Exercise during the last two hours of the hemodialysis session
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Fasting, Immune Function
The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans.
- Conditions
- Fasting, Immune Function, Glucose Tolerance
- Trial name
- FASTEX (NCT06737224)
- Testing
- Fasting + Exercise (FAST+EX): fasting + exercise condition, Fasting only (FAST): Non-exercise fasting condition
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Obstructive Pulmonary Disease
Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in COPD
Pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest.
- Trial name
- NCT01173328
- Testing
- Pursed-lip breathing, Normal Breathing
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro