Clinical trials: Exfoliation Syndrome
Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma
Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma
The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991.
- Conditions
- Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT00494923
- Where
- Germany
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Frailty Syndrome
Adaptation and Validation of Frailty Scales in Intensive Care Units in Spain
Increased life expectancy leads to population aging, increased morbidities and aging of hospitalized patients. The acquisition of frailty leads to worse outcomes derived from hospitalization, but although frailty has been related…
- Trial name
- NCT04830865
- Where
- Spain
- Volunteers
- 512 people
- Sponsor
- Hospital Universitario Getafe
Open Angle Glaucoma, Primary Open Angle Glaucoma
Safety and Effectiveness of the Hydrus Microstent
The purpose of this study is to assess the safety and effectiveness of the Hydrus Microstent for lowering intraocular pressure (IOP) in pseudophakic patients with open-angle glaucoma for whom IOP is not sufficiently controlled on…
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigmentary Glaucoma
- Trial name
- FRONTIER (NCT05198297)
- Testing
- Hydrus Microstent, Ophthalmic surgery
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- Alcon Research
Glaucoma, Open-Angle, Pseudoexfoliation Glaucoma
Optimal Treatment Protocol for Selective Laser Trabeculoplasty
A randomized controlled trial to evaluate which treatment protocol in selective laser trabeculoplasty that is most optimal in terms of efficacy and safety.
- Conditions
- Glaucoma, Open-Angle, Pseudoexfoliation Glaucoma, Ocular Hypertension
- Trial name
- OSLT (NCT03798223)
- Testing
- SLT
- Where
- 4 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Vastra Gotaland Region
Pseudoexfoliation Syndrome in Cataract Myopic Eyes
Pseudoexfoliation Syndrome in Myopes
A retrospective study of 5753 eyes of cataract surgery patients was conducted at our Clinic. Ocular optical components measured by optical low coherence reflectometry biometer LENSTAR LS 900® of the cataract myopic eyes with…
- Trial name
- NCT01637740
- Volunteers
- 5,753 people
- Sponsor
- General Hospital Sveti Duh
Open Angle Glaucoma, Ocular Hypertension
Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Pseudoexfoliation Syndrome
- Trial name
- NCT00121147
- Testing
- Travatan, Azopt, Alphagan P
- Where
- 21 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hermann Eye Center
Glaucoma, Glaucoma, Open Angle
AqueSys XEN 45 Glaucoma Implant in Refractory Glaucoma
To establish the safety and performance of the AqueSys XEN 45 Glaucoma Implant in eyes with refractory glaucoma.
- Trial name
- NCT02036541
- Testing
- AqueSys XEN 45 Glaucoma Implant
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- AqueSys, Inc.
Glaucoma, Open-Angle
The Effect of Pseudoexfoliation on Choroidal Thickness in Open Angle Glaucoma
Purpose: To investigate the effect of pseudoexfoliation (PEX) on choroidal thickness in primary open-angle glaucoma (POAG). Methods: This prospective, randomized study included 30 POAG patients and 30 PEX glaucoma patients with…
- Trial name
- NCT03373942
- Testing
- Choroidal thickness measurements with SD-OCT device
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Emine Deniz Egrilmez
Pseudoexfoliation Syndrome
LOXL1 Polymorphism in Pseudoexfoliation Syndrome
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.
- Trial name
- NCT01515735
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Glaucoma Open-Angle Primary, Pseudo Exfoliation Syndrome
Monitoring of the IOP After SLT Using iCare Home
The purpose of this study is to investigate how much selective trabeculoplasty (SLT) influences intraocular pressure (IOP) fluctuations measured with iCare Home rebound tonometry (RTHome) in patients with primary open-angle…
- Trial name
- NCT03310788
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- St. Erik Eye Hospital
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Intraocular Pressure After Preserflo / Innfocus Microshunt Implantation vs Trabeculectomy
The aim of this project is to compare trabeculectomy with Preserflo / Innfocus Microshunt in patients with Primary Angle Open Glaucoma and Pseudoexfoliation Glaucoma regarding the reduction of intraocular pressure.
- Trial name
- PAINT (NCT04440527)
- Testing
- Preserflo / Innfocus Microshunt, Trabeculectomy
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Medical University Innsbruck
Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes
Correlation Between Pupil Size and Ocular Signs of Pseudoexfoliation Syndrome
To study possible correlation between the size of the pupil in both room light and after dilation between both eyes in bilateral pseudoexfoliation with Intraocular pressure, lens clarity and stability, Optic disc , Visual changes…
- Conditions
- Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes, Pseudoexfoliation of Lens; Glaucoma
- Trial name
- NCT05113121
- Testing
- , Humphrey visual field (24-2) analysis and optical coherence tomography on retinal nerve fiber layer (RNFL) and ganglion cell complex.(GCC)
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Open Angle Glaucoma, Ocular Hypertension
The Diurnal and Nocturnal Effect of Simbrinza and Timolol on Intraocular Pressure and Ocular Perfusion Pressure
The purpose of this research study is to hypothesize that Simbrinza will achieve a decrease in intraocular pressure and increase in ocular perfusion pressure throughout the diurnal and nocturnal periods.
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Pigment Dispersion Syndrome, Pseudoexfoliation Glaucoma
- Trial name
- NCT02165631
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Refractive Errors, Cataract
Refractive Outcomes After Cataract Surgery in Eyes With Pseudoexfoliation Syndrome
To evaluate the refractive outcomes of cataract surgery in PEX syndrome and determine which of the commonly used IOL formulas (SRK/T, Barrett Universal II and Hill-RBF) is the best in predicting postoperative refractive outcomes…
- Trial name
- NCT04783909
- Testing
- Phacoemulsification cataract surgery
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Bacteremia, Infective Endocarditis
Reducing Risk for Infective Endocarditis
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth.
- Trial name
- PIE-B (NCT05721781)
- Testing
- Oral Hygiene instruction, Dental Cleaning
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pseudo Exfoliation Syndrome
Natural History of IOL in Pseudo Exfoliation Syndrome
The purpose of this study is to determine the natural course of IOL in PXF, To demonstrate use of a clinical grading system for PXF, To strategize a way to prevent IOL dislocation, subluxation post operatively, To demonstrate…
- Trial name
- PXF (NCT01255995)
- Testing
- Capsular Tension Ring
- Where
- 4 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Aurolab
Glaucoma, Open-Angle, Pseudoexfoliation Glaucoma
Optimal Treatment Protocol for Selective Laser Trabeculoplasty - Repeat Trial
Glaucoma is a common eye disease that can lead to blindness. The only known way to reduce the rate of disease progression is by reducing the pressure in the eye (the intraocular pressure, IOP).
- Conditions
- Glaucoma, Open-Angle, Pseudoexfoliation Glaucoma, Ocular Hypertension
- Trial name
- OSLT-R (NCT05159960)
- Testing
- SLT
- Where
- 2 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Vastra Gotaland Region
Glaucoma, Primary Open Angle Glaucoma
Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma
Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- TES-GPS (NCT06682962)
- Testing
- Transcorneal electrical stimulation (TES) with the OkuStim 2 System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Okuvision GmbH
Lens Diseases
Association Between Pseudoexfoliation Syndrome and Diabetes Mellitus
Pseudoexfoliation syndrome (PEX) is characterized by the deposition of a distinctive fibrillar material in the anterior segment of the eye and was first described in 1917 by Lindberg.
- Trial name
- NCT03741153
- Testing
- slit lamp
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pseudoexfoliation Syndrome
Optical Low Coherence Reflectometry Enables Preoperative Detection of Zonular Weakness in Pseudoexfoliation Syndrome
The purpose of the study was to evaluate optical ocular components in patients with pseudoexfoliation syndrome using optical low coherence reflectometry.
- Trial name
- NCT01298895
- Where
- Croatia
- Volunteers
- 224 people
- Sponsor
- General Hospital Sveti Duh