Clinical trials: Exhaled Breath Condensate
Covid19, Corona Virus Infection
Non-invasive Prognostication of COVID-19 Patients by Use of Biomarkers in Exhaled Breath Condensate
The main objective of this study is to assess if analysis of exhaled breath condensate (EBC) can provide useful prognostic markers for admission to the intensive care unit (ICU) due to acute respiratory insufficiency among…
- Trial name
- VTE-COVID-19 (NCT04598620)
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Inger Lise Gade
Asthma, Healthy
Inflammatory Markers in Exhaled Breath (Condensate) in Childhood Asthma
Background: Exhaled nitric oxide and inflammatory biomarkers in exhaled breath condensate may be useful to diagnose and monitor childhood asthma.
- Conditions
- Asthma, Healthy, Children
- Trial name
- NCT00404976
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pulmonary Embolism
Non-invasive Diagnosis of Pulmonary Embolism by Use of Biomarkers in Exhaled Breath Condensate
In this study, a new, non-invasive method for diagnosis of pulmonary embolism (PE) will be tested. In pre-clinical studies, we have identified 151 putative biomarkers for pulmonary embolism in the exhaled breath condensate (EBC).
- Trial name
- NCT04010760
- Testing
- Test of biomarkers for PE in EBC
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Proof Of Concept Study
Measuring Hydrogen Peroxide in Exhaled Breath Condensate in HV
The purpose of this study is to evaluate the performance of an Exhaled Breath Condensate (EBC) device. EBC measurements can be used for the assessments of lung inflammation in asthma and chronic obstructive pulmonary disease…
- Trial name
- NCT05844553
- Testing
- Measurement of inhaled measuring hydrogen peroxide in exhaled breath
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma
Sample Collections From the Airways of Asthmatic Patients
Fiberoptic bronchoscopy is a procedure which involves passing a pencil-thin tube into the lung in order to collect fluid and cells from the airways.
- Trial name
- NCT00001888
- Where
- United States
- Volunteers
- 574 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma, Vitamin D Deficiency
The Effect of Vitamin D Replacement on Airway Reactivity, Allergy and Inflammatory Mediators in Exhaled Breath Condensate in Vitamin D Deficient Asthmatic Children
Research Title: The effect of vitamin D replacement on airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D deficient asthmatic children.
- Trial name
- NCT01287455
- Testing
- Vitamin D3 as "BABY D3"
- Where
- Israel
- Volunteers
- 83 people
- Sponsor
- Rambam Health Care Campus
Attitude to Health
Mucociliary Clearance, Airway Inflammation and Nasal Symptoms in Urban Motorcycle-drivers
Professionals working in polluted areas may present increased airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis.
- Trial name
- NCT03510585
- Testing
- saline and sniffing, sniffing
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Asthma
The Anti-Inflammatory Effect of Extrafine HFA-Beclometasone Versus HFA-Fluticasone, by Means of Inflammometry
Background Chronic inflammation in peripheral airways plays an important role in the pathophysiology of asthma. Extrafine hydrofluoroalkane (HFA) beclometasone is distinguished from other ICS because of its fine aerosol…
- Trial name
- NCT00402207
- Testing
- extrafine HFA-beclomethasone, HFA-fluticasone
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Maastricht University Medical Center
Asthma
Biomarkers in Exhaled Breath From Asthmatic Patients
This study will look for a relationship between asthma and factors released from the lungs in exhaled breath. If a relationship can be established, the identified factors may be used as biomarkers to predict episodes of increased…
- Trial name
- NCT00635271
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ventilator Associated Pneumonia, Death
Futility of Exhaled Breath Condensate pH Measurements in Ventilated Patients in Intensive Care Unit (ICU)
Measurement of pH in Exhaled breath condensate has been mentioned as a robust variable from lung inflammation. It is non-invasive and reproducible.
- Trial name
- NCT01393431
- Where
- Argentina
- Volunteers
- 34 people
- Sponsor
- Universidad Nacional de Rosario
Interstitial Lung Disease, Lung Cancer
Assessment of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device (Inflammacheck™) in Patients With Interstitial Lung Disease, Lung Cancer and Healthy Volunteers.
A cross-sectional study of EBC H2O2 levels, as measured by a novel device, 'Inflammacheck™', and other markers of disease severity in patients with ILD and Lung Cancer.
- Trial name
- EXHALE 1B (NCT04061356)
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Bronchoalveolar Lavage Fluid, Sensitivity and Specificity
Aspergillosis Detection Via EBC-GM in Ventilated Patients
Brief Research Proposal: Non-Invasive Detection of Invasive Pulmonary Aspergillosis in ICU Patients Background: Invasive Pulmonary Aspergillosis (IPA) is a critical threat to patients in ICUs, especially those undergoing…
- Conditions
- Bronchoalveolar Lavage Fluid, Sensitivity and Specificity, Critical Illness, Respiration Failure
- Trial name
- NCT06333379
- Testing
- Compare the levels of Galactomannan (GM) levels in exhaled breath condensate (EBC) and BALF
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Lin Chen
Chronic Obstructive Pulmonary Disease
Systemic Endothelial Abnormalities in COPD
The purpose of this project is to validate the peripheral arterial pressure waveform measurements technique of RAAP (radial artery applanation tonometry), in patients with moderate and severe COPD (Chronic Obstructive Pulmonary…
- Trial name
- NCT00555529
- Testing
- radial artery applanation tonometry (RAAP)
- Where
- 2 sites in United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma, Children
Reduction of Asthma Exacerbation Rate in Children by Non-invasive Monitoring of Inflammatory Markers in Exhaled Breath (Condensate): the RASTER Study
The purpose of the present proposal was to investigate the predictive properties of markers in exhaled breath to predict an asthma exacerbation.
- Conditions
- Asthma, Children, Home Monitoring, Exhaled Breath Condensate
- Trial name
- RASTER (NCT01239238)
- Where
- 2 sites in Netherlands
- Volunteers
- 102 people
- Sponsor
- Maastricht University Medical Center
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Chronic Obstructive Pulmonary Disease
Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients
The aim of the study is to investigate the effect of inhaled apocynin on ROS (reactive oxygen species) and NOS (reactive nitrogen species) synthesis in 13 COPD patients.
- Trial name
- NCT01402297
- Volunteers
- 13 people
- Sponsor
- Medical University of Lodz
Asthma, Vitamin D Resistant Rickets
Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients
Research Title: Evaluation of airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D resistant rickets.
- Trial name
- NCT01578824
- Testing
- Methacholine Challenge Test
- Where
- Israel
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Sickle Cell Disease, Acute Chest Syndrome
sPLA2 in EBC During Acute Chest Syndrome
Secretory phosholipases A2 (sPLA2) are significantly elevated in the plasma of sickle cell disease patients with acute chest syndrome (ACS), and similar enzymes have been measured in exhaled breath condensate (EBC), which is…
- Trial name
- NCT03250585
- Testing
- Exhaled Breath Condensate (EBC), Plasma Sample
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Virginia Commonwealth University
Inadequate or Impaired Respiratory Function
The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers
Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of…
- Trial name
- Nanoexposure (NCT01599845)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Proof of Concept Study
Measuring Hydrogen Peroxide in Exhaled Breath Condensate in COPD
Following a successful pilot study and a clinical assessment in healthy volunteers (ClinicalTrials.gov ID: NCT05844553) this study aims to evaluate the accuracy and precision of an Exhaled Breath Condensate (EBC) device in…
- Trial name
- NCT06788457
- Testing
- Exhaled Breath Condensate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College London