Clinical trials: Exosome
Hair Loss, Alopecia
Exosome Effect on Prevention of Hairloss
Many people suffer from alopecia, which is caused by hereditary factors, emotional stress, and psychiatric disorders. There are devastating physical and psychological consequences as a result.
- Trial name
- NCT05658094
- Testing
- Exosome
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Diminished Ovarian Reserve
In Vitro Oocyte Maturation With Autologous Exosomes in Women
This study is a preliminary, prospective, randomized, controlled clinical trial designed to evaluate the safety and feasibility of supplementing in vitro maturation (IVM) media with autologous exosomes in women with diminished…
- Trial name
- Exosom2025-1 (NCT07249411)
- Testing
- MI oocytes were cultured in conventional IVM medium supplemented with 10 µg of autologous exosomes obtained using the ExoSMarT® exosome filtration system
- Where
- Venezuela
- Volunteers
- 32 people
- Sponsor
- Biotech Fertility C.A.
High Grade Serous Carcinoma, Ovarian Cancer
Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer
This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases.
- Conditions
- High Grade Serous Carcinoma, Ovarian Cancer, Exosomes, Prognosis
- Trial name
- NCT03738319
- Testing
- Sequencing of miRNA/lncRNA
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Lei Li
Rectal Cancer, Liquid Biopsy
A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Treatment Response Assessment in Rectal Cancer
Routine clinical and radiological assessment of response of patients with rectum cancer to neoadjuvant chemoradiotherapy does not allow accurate identification of complete pathological response, and leads to frequent false…
- Trial name
- RECC-EV (NCT04852653)
- Testing
- Supplementary blood samples collection during the normal follow up of the patients
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Bordeaux
Pancreatic Cyst
Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts
The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection.
- Trial name
- NCT07767227
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Translational Genomics Research Institute
Ischemic Stroke, Acute
Human Induced Neural Stem Cell-derived Exosomes for Treating Acute Ischemic Stroke
A phase I/IIa clinical trial investigating the safety and preliminary efficacy of intravenous administration of human induced neural stem cell-derived exosomes for acute ischemic stroke
- Trial name
- NSAIS (NCT07143786)
- Testing
- iNSC-EV01
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Thyroid Cancer, Papillary Thyroid Cancer
Urinary Exosomal Biomarkers of Thyroglobulin and Galectin-3 for Prognosis and Follow-up in Patients of Thyroid Cancer
Now, the investigators carried out a prospective study enrolling patients with thyroid cancer, who had received ablative thyroidectomy and /or radioactive iodine therapy for two more years.
- Conditions
- Thyroid Cancer, Papillary Thyroid Cancer, Follicular Thyroid Cancer
- Trial name
- NCT04948437
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
Kidney Transplantation
Major Activation Of NCC in Graft Urinary Exosomes
Hypertension is common disorder after renal transplantation and is associated with mortality. Calcineurin Inhibitor (CNI), by activating NCC cotransporter, may be a major determinant of hypertension, included in a "Gordon like"…
- Trial name
- MANGUE (NCT03503461)
- Testing
- exosomes analysis
- Where
- 2 sites in France, Reunion
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Obesity
Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific…
- Trial name
- NCT07031297
- Testing
- Meal Study
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Periodontitis
Evaluation of Adipose Derived Stem Cells Exo.in Treatment of Periodontitis
The adipose stem cells exosomes will be extracted from adipose stem cells isolated autogenously from the patient to be injected locally into the periodontal pockets in order to evaluate their regenerative effect.
- Trial name
- exosomes (NCT04270006)
- Testing
- adipose derived stem cells exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Diabetes, Exercise
Differential Regulation of miRNA and Protein in Human Plasma Extracellular Vesicles by Different Types of Exercise.
Aims/hypothesis: Both continuous aerobic training (CAT) and high intensity interval training (HIIT) are recommended to promote health and prevent diseases.
- Conditions
- Diabetes, Exercise, Lifestyle Intervention
- Trial name
- NCT06609785
- Testing
- Exercise
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Dystrophic Epidermolysis Bullosa
MSC EVs in Dystrophic Epidermolysis Bullosa
INVESTIGATIONAL PRODUCT: AGLE-102 is an allogeneic extracellular vesicle (EV) product derived from normal donor mesenchymal stem cells (MSCs).
- Trial name
- NCT04173650
- Testing
- AGLE-102
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Aegle Therapeutics
Amyotrophic Lateral Sclerosis
Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS
This is a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial. The goal of this clinical trial is to evaluate the safety and preliminary efficacy of nasal drop exosomes derived from human umbilical…
- Trial name
- de-ALS (NCT06598202)
- Testing
- exosomes derived from human umbilical cord blood mesenchymal stem cells for nasal drop
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Laser Therapy, Exosomes
Enhancing Skin Rejuvenation Using Laser and Exosomes
Enhancing Skin Rejuvenation A Single-Blind, Randomized Control Study on the Combined Efficacy of Aerolase 1064 nm YAG Laser and Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells
- Trial name
- NCT07281690
- Testing
- 1064-nm Nd:YAG Laser Treatment, Topical Umbilical Cord-Derived Exosomes (UC-MSC Exosomes)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laser Beamer Skincare
Pancreatic
Tumor Exosome Liquid Biopsy Strategy to Diagnose Pancreatic Cancer
This is an observational study of patients diagnosed with pancreatic cancer by pathology, with a control group of patients with pathology suggestive of benign pancreatic lesions and normal subjects, and the diagnostic ability of…
- Trial name
- NCT06108531
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Skin Aging, Facial Rhytides
AnteAGE Biosomes With Radiofrequency Microneedling for Facial Skin Rejuvenation
This prospective, randomized controlled study evaluated the efficacy and tolerability of AnteAGE Biosome Solution used in conjunction with facial radiofrequency microneedling.
- Conditions
- Skin Aging, Facial Rhytides, Skin Tone
- Trial name
- NCT07849556
- Testing
- AnteAGE Biosome Treatment Solution, Radiofrequency Microneedling, AnteAGE Homecare Regimen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cellese Inc.
Dry Eye Disease
Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm
The purpose of this study is to evaluate the preliminary safety and effectiveness of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops in the treatment of dry eye diseases post refractive surgery…
- Trial name
- NCT05738629
- Testing
- Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastric Cardia Cancer
Integrative Analysis of Exosome-Mediated Single-Cell Transcriptomics and Proteomics in Gastric Cardia Cancer
This is an observational study with a case control design. This study included patients with gastric cancer confirmed by pathological diagnosis of gastric tissue, and matched the control population according to age, gender, etc.
- Trial name
- NCT06702891
- Testing
- Detection of biological samples based on exosome sequencing, proteomics and single-cell RNA sequencing
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Rectal Cancer
Exosomes in Rectal Cancer
The primary aims of this study is to characterize exosomal biomarker levels in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation therapy.
- Trial name
- NCT03874559
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Dry Eye Syndrome (DES), Sjogren's Syndrome
Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome
By analyzing the differential proteins in exosomes, this study aims to understand the pathological mechanisms of SJS and DES, identify potential diagnostic and therapeutic methods, and advance the diagnosis and treatment of these…
- Conditions
- Dry Eye Syndrome (DES), Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06771427
- Testing
- acupuncture GB20 or GB20 plus BL2, Chinese herbal tea TBDESJS
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan