Clinical trials: Exosome
Coronary Artery Bypass Surgery
Study of Role of Blood Microvescicles and Exosomes in Patients With Graft Occlusion After Aortocoronary Bypass Surgery
Coronary artery bypass graft (CABG) surgery is still the standard treatment of coronary revascularization for patients with severe coronary artery disease (CAD).
- Trial name
- MVBYPASS (NCT05411445)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Maria Cecilia Hospital
NSCLC (Advanced Non-small Cell Lung Cancer)
Predictive Value of Exosomes in Pleural Effusion for Advanced Lung Cancer
The goal of this observational study is to investigate the predictive value of exosome characteristics in patients with advanced non-small cell lung cancer (NSCLC) and malignant pleural effusion (MPE).
- Trial name
- MPE-NSCLC (NCT07262671)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Hepatocellular Carcinoma
Clinical Study for Combined Analysis of CTC and Exosomes on Predicting the Efficacy of Immunotherapy in Patients With Hepatocellular Carcinoma
This project intends to perform CTC PD-L1 imaging, exosomal PD-L1 protein detection, and exosomal LAG-3 protein detection, so as to resolve the functional marker profiles of immunotherapy in the peripheral blood of HCC patients…
- Trial name
- NCT05575622
- Testing
- CTC PD-L1, exosomal PD-L1, and exosomal LAG-3 detection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhongnan Hospital
PDAC - Pancreatic Ductal Adenocarcinoma
Forecasting Occult liveR Metastasis Using an Exosomal Signature for Intelligent Guided Hepatic Targeting
Early liver metastasis (Early-LiM) is the most significant prognostic factor in pancreatic ductal adenocarcinoma (PDAC) and is thought to originate from occult micrometastases present at the time of surgery.
- Trial name
- FORESIGHT (NCT07224802)
- Testing
- EXELiM assay (qRT-PCR validation), EXELiM small RNA sequencing
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- City of Hope Medical Center
Chronic Mechanical Lower Back Pain, Lower Back Pain
Adia Med of Winter Park LLC Lower Back Pain Research Study
The goal of this clinical study is to evaluate the safety and preliminary efficacy of an investigational umbilical cord blood-derived stem cell and exosome infusion in adults with chronic lower back pain associated with…
- Conditions
- Chronic Mechanical Lower Back Pain, Lower Back Pain, Chronic Lower Back Pain
- Trial name
- NCT07587047
- Testing
- Umbilical Cord Blood-Derived Stem Cells and Exosomes
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Adia Med of Winter Park LLC
Non Small Cell Lung Cancer
Trial of a Vaccination With Tumor Antigen-loaded Dendritic Cell-derived Exosomes
Lung cancer is the worldwide leading cause of cancer death. In France, with 28,000 new cases per year, lung cancer is the 4th in terms of incidence but remains the leading cause of cancer death.
- Trial name
- CSET 1437 (NCT01159288)
- Testing
- Dex2
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Cancer
Feasibility of Exosome Analysis in Cerebrospinal Fluid During the Diagnostic Workup of Metastatic Meningitis
The investigators are interested in one of the most frequent tumor types causing leptomeningeal metastasis in order to investigate whether a profile can be established by a high-throughput clinical proteomic approach.
- Trial name
- Exo-LCR (NCT05286684)
- Testing
- Consultation, Cerebral and medullary MRI, lumbar puncture, CSF sampling, biological test
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Centre Oscar Lambret
Preeclampsia
Exosome Cargo From Preeclampsia Patients
Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia.
- Trial name
- NCT04154332
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2
Efficacy of Educational Nutrition and Exercise on the Regulation of Appetite Through Exosomes in Type 2 Diabetics
The aim of this randomized controlled trial is to investigate the effects of different aerobic modalities: moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), and a nutritional intervention…
- Trial name
- APETEX (NCT05259449)
- Testing
- Nutritional Intervention, High-intensity interval training (HIIT), Moderate-intensity continuous training (MICT)
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- University of Cadiz
Congenital Myasthenic Syndrome
Patients With Congenital Myasthenic Syndrome Will be Treated With Umbilical or Placental Derived Mesenchymal Stem Cell Exosome Solution
Patients with Congenital Myasthenic Syndrome will be treated with Umbilical or Placental Derived Mesenchymal Stem Cell Exosome solution.
- Trial name
- NCT07226726
- Testing
- AlloEx exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Melasma
Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Melasma
Melasma is a refractory skin disease with a complex pathogenesis and difficult treatment. Research has found that mesenchymal stem cell-derived exosomes have effects such as anti-wrinkle formation, anti-inflammation, antioxidant…
- Trial name
- NCT06677931
- Testing
- 1565 non-ablative fractional laser combined with umbilical cord mesenchymal stem cell-derived exosomes.
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Acute Ischemic Stroke
The Effect of GD-iExo-003 in Acute Ischemic Stroke
This is a multicenter, randomized, double-blinded, placebo-controlled, dose-escalation trial. The objective of this study is evaluating safety and preliminary efficacy of intravenous exosomes derived from human induced…
- Trial name
- ExoCURE (NCT06138210)
- Testing
- exosomes derived from human induced pluripotent stem cell for injection
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Xuanwu Hospital, Beijing
Lung Cancer, Diagnosis
Comparision of Various Biomarkers Between Peripheral and Pulmonary Blood
Lung cancer is a leading cause of cancer death worldwide. Early diagnosis is linked to a better prognosis. Further, surgical resection at the early stages of non-small cell lung cancer (NSCLC) results in markedly improved…
- Trial name
- NCT05587114
- Testing
- frozen blood plasma samples
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Korea University Guro Hospital
Healthy
A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers
Exosomes are naturally occurring nanosized vesicles and comprised of natural lipid bilayers with the abundance of adhesive proteins that readily interact with cellular membranes.
- Trial name
- NCT04313647
- Testing
- 1X level of MSCs-Exo, 2X level of MSCs-Exo, 4X level of MSCs-Exo
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
NSCLC
Clinical Research for the Consistency Analysis of PD-L1 in Cancer Tissue and Plasma Exosome
The detection of tissue PD-L1 immunohistochemistry in Non-small cell lung cancer (NSCLC) has an important role in guiding for the treatment of immune detection point.
- Trial name
- RadImm01 (NCT02890849)
- Testing
- Liquid biopsy
- Volunteers
- 60 people
- Sponsor
- Xinqiao Hospital of Chongqing
Erectile Dysfunction Due to Arterial Insufficiency
PRP Exosomes Therapy for Erectile Dysfunction
It will be a Single-arm, single-center, feasibility clinical trial with Primary Objective to investigate the treatment efficacy of PRP-derived exosomes injection in men with mild-moderate vasculogenic ED, as measured by the…
- Trial name
- NCT07124871
- Testing
- PRP-derived exosomes injection
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Institute for the Study of Urological Diseases, Greece
Covid19, Novel Coronavirus Pneumonia
The Use of Exosomes for the Treatment of Acute Respiratory Distress Syndrome or Novel Coronavirus Pneumonia Caused by COVID-19
Novel coronavirus pneumonia (NCP) and acute respiratory distress syndrome (ARDS) are both associated with the prevailing upper respiratory tract infections caused by the RNA-containing SARS-CoV2 virus of the genius…
- Conditions
- Covid19, Novel Coronavirus Pneumonia, Acute Respiratory Distress Syndrome
- Trial name
- ARDOXSO (NCT04798716)
- Testing
- MSC-exosomes delivered intravenously every other day on an escalating dose: (2:4:8), MSC-exosomes delivered intravenously every other day on an escalating dose (8:4:8), MSC-exosomes delivered intravenously every other day (8:8:8)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- AVEM HealthCare
Intrahepatic Cholangiocarcinoma (Icc)
Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.
Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking.
- Trial name
- EXOMIC (NCT07224737)
- Testing
- EXOMIC small RNA sequencing, EXOMIC assay (qRT-PCR validation)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Diabetic Retinopathy
Proteomic Study of Plasma Exosomes in Patients With Diabetic Retinopathy
Objective: Explore the biomarkers related to proliferative diabetic retinopathy by analyzing the protein expression profile changes of plasma exosomes in patients with difference phases of diabetic retinopathy, and investigate…
- Trial name
- NCT06188013
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Heart Failure
A First-in-Human Study to Evaluate the Safety and Efficacy of Left Ventricular Assist Device Combined With Exosome Therapy for Patients With Heart Failure（RESTORATION）
A single-center, randomized, double-blind, placebo-controlled, dose-escalation clinical study to evaluate the safety and tolerability of intravenous infusion of different doses of the investigational exosome preparation in heart…
- Trial name
- NCT07883317
- Testing
- Exosome Preparation
- Volunteers
- 24 people
- Sponsor
- Yining Yang