Clinical trials: Exosome
Macular Holes
MSC-Exos Promote Healing of MHs
Purpose: To assess the safety and efficacy of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exos) for promoting healing of large and refractory macular holes (MHs).
- Trial name
- MSCs (NCT03437759)
- Testing
- exosomes derived from mesenchymal stem cells (MSC-Exo)
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Radiation Cystitis
Clinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Combined With Sodium Hyaluronate Intravesical Instillation in the Treatment of Radiation Cystitis
The goal of this clinical trial is to learn whether intravesical instillation of human umbilical cord mesenchymal stem cell-derived exosomes combined with sodium hyaluronate is safe and effective for treating radiation cystitis.
- Trial name
- NCT07665619
- Testing
- Exosomes (hUC-MSC-Exo), Sodium Hyaluronate (Hyalein), Normal Saline (0.9% NaCl)
- Volunteers
- 48 people
- Sponsor
- Fujian Medical University Union Hospital
Acne Scars - Atrophic
Comparative Study of The Efficacy and Safety of Subcision Combined With Injection of Exosomes Versus Subcision Alone in Treatment of Atrophic Post- Acne Scars.
This split-face comparative prospective study was carried out on 20 patients presenting with atrophic post-acne scars. All participants were subjected to full history taking, general and dermatological examination, photographing…
- Trial name
- NCT07906509
- Testing
- Subcision plus exosome injection, Subcision
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Tanta University
Rectal Cancer
Effects of Exosome Adminstration in Preventing Early Leakage in Rectal Cancer Patients Undergoing Low Anterior Resection
The goal of this clinical trial is to assess the safety and efficacy of Human Placenta Mesenchymal Stem Cells Derived Exosomes in preventing early anastomosis leak in patients undergoing low anterior resection for rectal cancer.
- Trial name
- NCT06536712
- Testing
- Mesenchymal Stem Cells Derived Exosomes
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Androgenetic Alopecia (AGA)
Exosome Therapy for Male Androgenetic Alopecia
The goal of this clinical trial is to learn if local scalp injection of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) can treat androgenetic alopecia (AGA) in male patients with AGA.
- Trial name
- NCT07693244
- Testing
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhang Han
Diabetic Retinopathy
Role of the Serum Exosomal miRNA in Diabetic Retinopathy (DR)
Diabetic retinopathy (DR) is one of the most common causes of blindness worldwide. It is a progressive disease and its detection in early phases is very crucial for visional outcomes.
- Trial name
- NCT03264976
- Testing
- hematological examination, ophthalmic examination
- Volunteers
- 200 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cerebrovascular Disorders
Allogenic Mesenchymal Stem Cell Derived Exosome in Patients With Acute Ischemic Stroke
Administration of cell-free exosomes derived from mesenchymal stem cell (MSCs) can be sufficient to exert therapeutic effects of intact MSCs after brain injury.
- Trial name
- NCT03384433
- Testing
- exosome
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Isfahan University of Medical Sciences
Retinitis Pigmentosa
The Effect of Stem Cells and Stem Cell Exosomes on Visual Functions in Patients With Retinitis Pigmentosa
This clinical trial aims to study the efficacy of umbilical cord-derived mesenchymal stem cells and their exosomes in the treatment of retinitis pigmentosa. The participants will be randomized into 3 groups.
- Trial name
- NCT05413148
- Testing
- Subtenon injection of Wharton jelly derived mesenchymal stem cells, Subtenon injection of Wharton jelly derived mesenchymal stem cell exosomes
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- TC Erciyes University
Clear Cell Renal Cell Carcinoma
Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential.
- Trial name
- PEP-C (NCT04053855)
- Testing
- Urinary sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy Volunteers (HV), Skin Irritation
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers for Future Surgical Wound Use
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-MELSAFE (NCT07707986)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Prostate Cancer
Clinical Validation of a Urinary Exosome Gene Signature in Men Presenting for Suspicion of Prostate Cancer
Validate a non-DRE exosome gene expression test, with an NPV >/= 90% certainty, will exclude the presence of high gleason grade/ score (>/=7) prostate cancer in a prostate needle biopsy.
- Trial name
- NCT02702856
- Testing
- ExoIntelliScore Prostate
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Exosome Diagnostics, Inc.
Premature Birth, Extreme Prematurity
The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants
To study the safety and efficacy of intranasal administration of exosomes derived from mesenchymal stromal cells on long-term neurodevelopmental outcome in extremely low birth weight infants born at gestational age 25/0-27/6…
- Conditions
- Premature Birth, Extreme Prematurity, Preterm Intraventricular Hemorrhage, Hypoxia-Ischemia, Cerebral
- Trial name
- NCT05490173
- Testing
- Exosomes derived from mesenchymal stromal cells (MSCs)
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Rectal Neoplasm Malignant Carcinoma, Chemoradiotherapy
Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer
Backgrounds: A multicenter randomized phase III trial (NCT02605265) proved that adding irinotecan guided by UGT1A1 to capecitabine-based neoadjuvant chemoradiotherapy significantly increases complete tumor response.
- Conditions
- Rectal Neoplasm Malignant Carcinoma, Chemoradiotherapy, Neoadjuvant Therapy, Predictive Biomarkers
- Trial name
- NCT04227886
- Testing
- Radiation, Capecitabine-Irinotecan Combination
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Perianal Fistula in Patients With Crohn's Disease
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's Patients
Study aim: Safety of Human Placenta Mesenchymal Stem Cells Derived Exosomes for treatment of perianal fistula in patients with Crohn's disease 2.
- Trial name
- NCT05499156
- Testing
- placenal MSC derived exosomes
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Type 2 Diabetes Mellitus
Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) Therapy for Type 2 Diabetes Mellitus Patients
This is an open-label randomized controlled trial with a pre-and-post-test control group design to evaluate the effect of Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) as an adjunctive therapy on glycemic control and…
- Trial name
- NCT07144241
- Testing
- Mesenchymal Stromal/Stem Cells-Derived Exosomes (Exo-HWS + 1 vial Exo-HUVEC) Therapy, Mesenchymal Stromal/Stem Cells-Derived Exosomes (Exo-HWS ) Therapy
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Age Related Macular Degeneration, Mild Cognitive Impairment (MCI)
Association Between Age-related Macular Degeneration and Cognitive Impairment Based on Exosome Proteomics
Aim: Preliminary serum exosomal proteomics of patients with dry age-related macular degeneration (AMD) and mild cognitive impairment (MCI) were analyzed using proteomics technology.
- Conditions
- Age Related Macular Degeneration, Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
- Trial name
- NCT06883461
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Radiation-induced Esophagitis
Spirulina Derivative for Radiation Esophagitis
To evaluate the efficacy and safety of a Spirulina-derived product in preventing and treating radiation-induced esophagitis in esophageal cancer patients undergoing intensity-modulated radiotherapy (IMRT).
- Trial name
- NCT07324018
- Testing
- Hydrogel of spirulina-derived exosomes., Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Androgenetic Alopecia
Efficacy and Safety Of AGE ZERO™ EXOSOMES To Treat Men and Women With Androgenetic Alopecia
The purpose of this study is to determine whether Wharton's Jelly mesenchymal stem cell-derived exosome microneedling on the scalp is an effective treatment for Androgenetic Alopecia (pattern hair loss).
- Trial name
- NCT06482541
- Testing
- 5 billion exosomes and saline solution microneedling, 50 billion exosomes and saline solution microneedling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Levit Dermatology
Mild to Moderate Alzheimer's Disease
The Effect of CB-Exo-A600 in Mild to Moderate Alzheimer's Disease
This study is divided into two phases: a dose-escalation phase and an expansion cohort phase. The dose-escalation phase is a single-center study, while the expansion cohort phase is a multicenter, prospective, randomized…
- Trial name
- CB-EXOAD (NCT07457125)
- Testing
- Exosomes derived from umbilical cord mesenchymal stem cell for intranasal drop
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xuanwu Hospital, Beijing
Frontotemporal Dementia
MSC-Exosome Therapy for Frontotemporal Dementia
This study is testing a new treatment for Frontotemporal Dementia (FTD) - a progressive brain disease that affects personality, behavior, and language.
- Trial name
- NCT07638813
- Testing
- Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes （Low-Dose）, Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes （High-Dose）
- Volunteers
- 33 people
- Sponsor
- Ruijin Hospital