Clinical trials: Exosomes
Sjogren Syndrome, Xerostomia
Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome
This study will evaluate the effects of exosome and mesenchymal stem cell injections into the submandibular glands of adults with primary Sjögren syndrome and salivary gland dysfunction or dry mouth.
- Conditions
- Sjogren Syndrome, Xerostomia, Exosome
- Trial name
- NCT07838454
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Banu Erkal
Androgenetic Alopecia, Exosomes
Exosome Injection Versus Topical Minoxidil for Androgenetic Alopecia
Androgenetic alopecia (AGA) is a common form of hair loss characterized by progressive hair follicle miniaturization. This prospective randomized comparative study evaluates the efficacy and safety of intradermal exosome…
- Trial name
- EXO-MINO (NCT07776015)
- Testing
- exosomes injection, Topical Minoxidil 5%
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Lung Cancer, Exosomes
Molecular Profiling of Exosomes in Tumor-draining Vein of Early-staged Lung Cancer
This is an observational prospective single-center study of 30 patients operated for early-staged non-small cell lung cancer. The main aim is the analysis of molecular profiling of exosome with a sample in tumor-draining vein in…
- Conditions
- Lung Cancer, Exosomes, Non Small Cell Lung Cancer
- Trial name
- ExOnSite-Pro (NCT04939324)
- Testing
- Blood samples at 2 sites: peripheral vein and tumor-draining vein
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Limoges
Pneumonitis, Interstitial, Immune Checkpoint Inhibitors (ICIs)
Exploratory Study on the Efficacy and Safety of Nebulized hUC-MSC-Derived Exosomes for Non-Acute CIP
Study Objectives The primary objective of Phase II is to evaluate the percentage of lesion resolution on high-resolution computed tomography (HRCT) as assessed by independent blinded reviewers.
- Conditions
- Pneumonitis, Interstitial, Immune Checkpoint Inhibitors (ICIs), Mesenchymal Stem Cells, Exosomes
- Trial name
- NCT07599111
- Testing
- Nebulized hUCMSC-Exos, Nebulized normal saline
- Volunteers
- 40 people
- Sponsor
- Zhou Chengzhi
Sensori-Neural Deafness, Exosomes
A Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.
Primary Objective To compare the efficacy of a single course of IT Exo-Dex versus conventional IT dexamethasone and exosome vehicle alone, as measured by the mean change in pure-tone average (PTA; 0.5, 1, 2, 4 kHz) from baseline…
- Trial name
- EXO-DEX-SNHL (NCT07568184)
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Vitiligo, Mesenchymal Stem Cells
Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Vitiligo
This study evaluates whether exosomes derived from human umbilical cord mesenchymal stem cells (hUMSCs-Exo) are safe and effective for treating vitiligo in adults.
- Conditions
- Vitiligo, Mesenchymal Stem Cells, Exosomes
- Trial name
- hUMSCs-Exo-VIT (NCT07519031)
- Testing
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Intravenous Infusion, Oral Prednisone, Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Local Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Xijing Hospital
Sudden Cardiac Death, Exosome Multiomics
Early Evaluation of Exosome Multiomics and Clinical Prognosis in Patients With Sudden Death
Acute coronary syndrome (ACS) is one of the main causes of death. Worldwide, tens of millions of patients are hospitalized for coronary heart disease and ACS every year.
- Conditions
- Sudden Cardiac Death, Exosome Multiomics, Clinical Prognosis
- Trial name
- NCT06856993
- Testing
- standardized medical care of cardiac arrest
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Intrauterine Adhesions, Exosomes
Clinical Study on the Effect of Umbilical Cord Mesenchymal Stem Cell Exosomes on Endometrial Repair of Intrauterine Adhesions
Intrauterine adhesions (IUA) is a group of diseases caused by endometrial injury leading to occlusion of the uterine cavity and serious abnormality of the uterine cavity morphology, which causes primary or secondary infertility…
- Trial name
- NCT07416578
- Testing
- Exosmoes, HRT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer, Liver Metastases From Colorectal Cancer
Prospective Cohort Study on the Relationship Between Exosomal Peroxiredoxin 1 (PRDX1) and Postoperative Liver Metastasis
The occurrence of liver metastasis after curative surgery for resectable colorectal cancer is an important cause of death for patients.
- Conditions
- Colorectal Cancer, Liver Metastases From Colorectal Cancer, Pathology, Exosome
- Trial name
- NCT07177742
- Testing
- Observation
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Mu-qing Yang
Healthy Subjects, Exosome
A Study to Investigate HLA-G Targeted Exosome (SOB100) in Healthy Subjects
The investigational drug, SOB100, is an HLA-G targeted exosome equipped with a nanobody namely anti-HLA-G VHH on the exosome membrane.
- Conditions
- Healthy Subjects, Exosome, Targeted Therapy
- Trial name
- αHLA-G Exo-01 (NCT07219940)
- Testing
- SOB100
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shine-On Biomedical Co., Ltd.
Breast Cancer, Digestive Cancer
Interest of Circulating Tumor DNA in Digestive and Gynecologic/Breast Cancer
Circulating tumor DNA (ctDNA) offers the possibility of accessing the tumor genome from circulating blood through a simple blood test.
- Conditions
- Breast Cancer, Digestive Cancer, Gynecologic Cancer, Circulating Tumor DNA
- Trial name
- NCT04530890
- Testing
- Blood samples
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Laser Therapy, Exosomes
Enhancing Skin Rejuvenation Using Laser and Exosomes
Enhancing Skin Rejuvenation A Single-Blind, Randomized Control Study on the Combined Efficacy of Aerolase 1064 nm YAG Laser and Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells
- Trial name
- NCT07281690
- Testing
- 1064-nm Nd:YAG Laser Treatment, Topical Umbilical Cord-Derived Exosomes (UC-MSC Exosomes)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laser Beamer Skincare
Preeclampsia, Postpartum
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
--- Why Is This Study Being Done? Women who have preeclampsia during pregnancy face a much higher risk of heart disease later in life.
- Conditions
- Preeclampsia, Postpartum, Endothelial Injury, Exosome Multiomics
- Trial name
- EXITPE (NCT07183384)
- Testing
- Mesenchymal Stem Cell-Derived Exosomes
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Padjadjaran
Pancreas Cancer, Exosomes
ExoLuminate Study for Early Detection of Pancreatic Cancer
ExoLuminate is a nationally-enrolling registry study designed for earlier detection of cancer in patients at elevated risk or clinically-suspicious for pancreatic ductal adenocarcinoma (PDAC).
- Conditions
- Pancreas Cancer, Exosomes, Extracellular Vesicles, Pancreatic Neoplasms
- Trial name
- NCT05625529
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Biological Dynamics
Androgenetic Alopecia, Exosomes
Exosome Treatment in Androgenetic Alopecia
This study aims to elucidate the effect of "foreskin-derived mesenchymal stromal cells derived exosome" injection into the scalp on hair density in patients with androgenetic alopecia and the contribution of this treatment on…
- Trial name
- NCT06539273
- Testing
- Exosome Complex, RNA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Yeditepe University Hospital
Diabetic Foot Ulcer (DFU), Exosomes
Efficacy and Safety of Wharton's Jelly-Derived Mesenchymal Stem Cell Exosomes in the Treatment of Diabetic Foot Ulcers: A Double-blinded Randomized Controlled Clinical Trial
Study effeciency and safety of WJ-MSC derived exosomes in DFU healing
- Trial name
- WJ-MSC (NCT06812637)
- Testing
- WJ-MSC- Exosomes, SOC (Standard of care)
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Kafrelsheikh University
Prostatic Neoplasms, Exosomes
Prognostic Study of Via Dynamic Change of PCA3 mRNA in Drainage Fluid After Radical Prostatectomy
This study investigates the prognostic value of dynamic changes in PCA3 mRNA levels found in the abdominal cavity drainage fluid after radical prostatectomy.
- Trial name
- NCT06707961
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Exosomes, Newborn
Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity
Metabolic bone disease of prematurity (MBDP) is caused by insufficient content of calcium, phosphorus, and organic protein matrix in preterm infants or bone metabolism disorder, which is one of the complications affecting the…
- Conditions
- Exosomes, Newborn, Bone Diseases, Metabolic
- Trial name
- NCT06368154
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hunan Children's Hospital
Exosome, Skin Regeneration
Clinical Observation of Exosomes in Patients After Q-switched Laser Surgery
the goal of this half-face controlled study is to evaluate the effect of exosome-containing liquid dressings on the recovery of patients after Nd:YAG laser 532 treatment.
- Conditions
- Exosome, Skin Regeneration, Laser
- Trial name
- NCT06279039
- Testing
- Exosome liquid dressing
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Exosomes, Connective Tissue
Exercise-induced Changes in Exosomes
The proposed study aims to shed light on the function/importance/relevance of exercise-induced changes in exosomes to connective tissues. Exosomes are known to increase robustly in response to exercise.
- Conditions
- Exosomes, Connective Tissue, Exercise
- Trial name
- NCT05616234
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis