Clinical trials: Experimental
Cannabis, Abuse Liability
Repeated CBD Administration and Cannabis Outcomes
This outpatient study examines how cannabidiol (CBD) affects the behavioral and pain-relieving effects of cannabis.
- Conditions
- Cannabis, Abuse Liability, Experimental Pain in Healthy Human Participants
- Trial name
- NCT07434895
- Testing
- Cannabidiol, Medium Dose, Cannabidiol, Higher Dose, Active Inhaled Cannabis
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hannah Harris
Experimental Pain, Hyperalgesia
Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers
The aim of this study is to assess the anti-hyperalgesic effect of dextromethorphan in healthy volunteers compared to placebo.
- Trial name
- Hydex (NCT02596360)
- Testing
- Pulmodexane® 30mg, lactose
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Experimental Pain, Low Back Pain
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
This study aims to identify spatiotemporal alterations in thalamocortical circuitry functioning in both healthy subjects and patients with chronic pain, combining multimodal neuroimaging.
- Trial name
- NCT05763758
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Kinesiophobia (Fear of Movement), Experimental Pain
Pain Beliefs and Intracortical Excitability During Experimental Pain
Pain can influence the way the motor system functions. However, responses to pain vary widely between individuals, and this variability may be partly related to pain-related beliefs such as kinesiophobia.
- Trial name
- NCT07688525
- Testing
- Topical Capsaicin Cream (1%)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Experimental, Control Condition
Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Drinking
Aim 1. Couples (N=50 dyads) with a Concerned Partner (CP) and a Drinking Partner (DP) will independently complete baseline and follow-up surveys and a 21-day EMA with three daily reports on their communication and DP's drinking.
- Trial name
- NCT06670794
- Testing
- Web-based intervention for concerned partners, Psychoeducation control
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Florida
Experimental Video Games, Behavioral Assessment
Gamified Digital Intervention to Enhance the Efficacy of Exposure Therapy for OCD
Aim 1 - Clinically analyze the game Militant of the Maze (MoM) as a vehicle for Exposure Theory, including, play, observation, and feedback from five clinicians.
- Trial name
- NCT05850312
- Testing
- Gamified Digital Intervention - Feasibility Analysis on MoM, Gamified Digital Intervention
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Idaho State University
Waitlist Control, Experimental
Effects of Youth Mental Health First Aid (YMHFA) on South Asian American Adults Working With South Asian American Youth
This study aims to adapt the Youth Mental Health First Aid training to better meet the needs of South Asian American adults who support South Asian American youth. Focus groups will help identify what changes are needed.
- Trial name
- NCT07135479
- Testing
- Youth Mental Health First Aid
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Acute Pain, Experimental Pain in Healthy Human Participants
Healthy Children and Virtual Reality Mediation of Simulated Pain
The objective of this study is to develop central nervous system (CNS) biomarkers of pain experienced during medical procedures and pain relief induced by Virtual Reality Pain Alleviation Therapy (VR-PAT).
- Conditions
- Acute Pain, Experimental Pain in Healthy Human Participants, Children, Adolescents
- Trial name
- NCT06854991
- Testing
- Active VR-PAT, Passive VR-PAT, iPad
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Placebo - Control, Experimental
What is the Role of Type III/IV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?
Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature.
- Trial name
- NCT07452094
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Control, Experimental
Statewide System and Organizational Strategy for EBP Implementation
This project will test an implementation strategy that seeks to align system, organization, and clinic leadership strategies to implement and sustain the Lyssn artificial intelligence (AI) quality assurance platform to support…
- Trial name
- LOCI-SL (NCT05344534)
- Testing
- Leadership and Organizational Change for Implementation
- Where
- United States
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Lung Inflammation, Experimental Lung Inflammation
Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air at Rest
The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm) or clean…
- Trial name
- LOCONOZ3 (NCT06943989)
- Testing
- Ozone Exposure, Clean air (0.0 ppm ozone)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
CONTROL, EXPERİMENTAL
The Effect of Gamified Instructional Material on Nursing Students' Aggressive Patient Management
Purpose: This study aims to determine the effect of game-based learning on aggressive patient management of nursing students. Material Method: The data of the study will be collected from senior nursing students in the 2024-2025…
- Trial name
- NCT06649149
- Testing
- Genially, Education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Experimental Pain in Healthy Human Subjects
How do Alpha Oscillations Shape the Perception of Pain? - An EEG-based Neurofeedback Study
Pain is closely linked to alpha oscillations (8 -13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing.
- Trial name
- NCT05570695
- Testing
- attention right training, ARTNF, attention left training, ALTNF
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Cancer Prevention, Health Behavior
Program of Health Behaviour Against to Cancer (PHeBAC)
The European Code Against Cancer contains 12 recommendations to reduce the risk of cancer. It is estimated that about half of all cancers could be prevented if all recommendations are followed.
- Conditions
- Cancer Prevention, Health Behavior, Disability, Intellectual, Parents
- Trial name
- PHeBAC (NCT06371469)
- Testing
- PHeBAC, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Control, Experimental
FLOAT Through Anxiety: Virtual Reality Application's Efficacy as a Tool to Distract From Negative Emotions and Thoughts
The goal of this clinical trial is to examine the effectiveness and safety of the VR FLOAT application as a tool to reduce negative thoughts and feelings and anxiety symptoms in students with high levels of stress and anxiety.
- Trial name
- NCT06197464
- Testing
- psychoeducation on emotional regulation and distraction strategy, Using the FLOAT app on a virtual reality device, psychoeducation on emotional regulation and distraction strategy + Application
- Where
- Israel
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Functionality of Experimental Contact Lens
Ocular Adaptation and Visual Performance for Accommodative Contact Lens
Presbyopes (people who might have a significant loss of their ability to accommodate their crystalline lens in the eye) will be recruited to wear a test lens and perform typical clinical tests of visual acuity with different…
- Trial name
- ACL (NCT02923232)
- Testing
- Accommodative contact lens
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Pacific University
Autoimmune Encephalomyelitis
Neuroinflammatory PET Imaging in Autoimmune Encephalomyelitis
Autoimmune encephalomyelitis is a heterogeneous group of central nervous system (CNS) autoimmune diseases characterized by the production of anti-neuron-associated autoantibodies which target neuronal surface proteins, synaptic…
- Trial name
- NCT05293405
- Testing
- 18F-DPA-714 PET
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Experimental Pain in Healthy Human Subjects
Intra- and Inter-individual Differences of Pain
Pain is a highly subjective and variable phenomenon. Different persons perceive objectively identical nociceptive stimuli differently.
- Trial name
- NCT05616091
- Testing
- painful stimulation by using a laser device (DEKA Stimul 1340, Calenzano, Italy)
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Pain, Experimental
Could Self-distancing Alter the Perception of Experimental Pain?
Physical pain leads to a narrow, egocentric focus on the self, in the here and now, particularly when experienced at high intensity levels.
- Trial name
- NCT05511857
- Testing
- Self-distancing, third-person self-talk., Self-immersed, first-person self-talk., Distraction
- Where
- Sweden
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Linnaeus University