Clinical trials: Exposure
Lung Diseases
American Lung Association (ALA) Lung Health Cohort
The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease.
- Trial name
- NCT04543461
- Where
- 37 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Vascular Endothelium
Health Effects of Biodiesel Exhaust Exposure
Urban air pollution is a major contributor to greenhouse gases and has been shown to increase cardiovascular mortality and morbidity.
- Trial name
- BD100 (NCT01883466)
- Testing
- Forearm venous occlusion plethysmography study
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Umeå University
Secondhand Tobacco Smoke Exposure Reduction
Reducing Breast Cancer Risk in Korean American Women
The goals of the study are to develop a culturally and linguistically appropriate intervention to reduce SHS exposure for LEP Korean women using a family-focused intervention approach targeting Korean Americans ages 18 and above…
- Trial name
- NCT04079556
- Testing
- Tobacco LHW
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Arsenic Exposure
Nutrition, Arsenic and Cognitive Function in Children
The main goals of this study are to evaluate whether supplementation with folate and vitamin B12 to 8 to 10 year old children, in conjunction with reduction in arsenic exposure, can increase arsenic methylation and lower blood…
- Trial name
- NCT03384862
- Testing
- Vitamin B12, Folic Acid
- Where
- Bangladesh
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cigarette Smoking
Characterization of Biomarkers of Tobacco Exposure, Urge-to-Smoke Following Exclusive and Dual Ad Lib Use of Electronic Cigarettes
This is a randomized, open-label, forced-switch, parallel, proof-of-concept study to assess exposure to biomarkers of tobacco exposure following short-term ad lib use of three blu e-cigarette products.
- Trial name
- NCT02385227
- Testing
- Exclusive blu™ e-cigarette A1, Exclusive blu™ e-cigarette A2, Exclusive blu™ e-cigarette A3
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Lorillard Tobacco Company
Social Phobia
Pilot Study: VR Mind and VR Mind+ Intervention
The aim of the pilot study is feasibility, usability and safety assessment of VR Mind intervention. In particular the subject of assessment will be: the length of the laboratory session utilizing virtual reality exposure…
- Trial name
- NCT03647605
- Testing
- VR Mind
- Where
- Poland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tomorrow Sp. z o.o.
HIV Preexposure Prophylaxis
The SwissPrEPared Study
Nested within the SwissPrEPared Program, the "SwissPrEPared Study" - a large, multicentric, nation-wide cohort study - aims to longitudinally follow individuals asking for PrEP prescription over a period of 3 years.
- Trial name
- NCT03893188
- Where
- 41 sites in Switzerland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Zurich
HIV Infections, Sexually Transmitted Diseases
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directed by the clinic.
- Trial name
- PCORI PrEP (NCT04855773)
- Testing
- PrEPmate, Dot Diary
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Posttraumatic Stress Disorder, PTSD
TDCS-Augmented Prolonged Exposure Therapy
The purpose of this study is to determine the effects of a brain stimulation technique known as transcranial direct current stimulation, or tDCS, on the benefits of Prolonged Exposure therapy, or PE, which is an effective…
- Conditions
- Posttraumatic Stress Disorder, PTSD, Anxiety, Depression
- Trial name
- NCT04327362
- Testing
- Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
HIV-1-infection
The Role of Home Packs of HIV PEPSE in High Risk Individuals
The study is looking at a new way to reduce the risk of catching HIV. Post-exposure Prophylaxis for sexual exposure (PEPSE) is where a month of HIV drugs can be given to reduce the chance of getting HIV, after a risk.
- Trial name
- Home PEPSE (NCT04965662)
- Testing
- Maraviroc, Truvada
- Where
- United Kingdom
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Endocrine Disruptors in Newborns and Infants
Impact of Parental Training in Endocrine Disruptors on the Excretion of Urinary Biomarkers in Newborns
The impact of the environment on health, responsible for a quarter of all deaths worldwide and costing more than €160 billion a year, is difficult to assess because of the complexity of exposure and interactions.
- Trial name
- FLOCON (NCT07349927)
- Testing
- Training, Questionnaires, Urinary dosage
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
PTSD, Substance Use Disorders
COPEWeb Training for Providers
Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans.
- Trial name
- COPEWeb (NCT05812131)
- Testing
- COPEWeb online training, COPE In Person
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Bone Regeneration
Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked
This study is being done to compare how quickly three different types of collagen membranes break down when they are exposed to the mouth.
- Trial name
- NCT06944639
- Testing
- Membrane Jason MB GmbH Non-cross-linked (NCL), Membrane BioMend Extend Glutaraldehyde cross-linked, Membrane OSSIX Agile Ribose cross-linked (RCL)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Andrea Ravida
Smoking Cessation
Nicotine Replacement Therapy and Cardiovascular Disease
The aim of this study is to compare the cardiovascular disease event rate in smokers undertaking pharmacologically unaided smoking cessation attempts (the non-exposed group) with the event rate in smokers attempting smoking…
- Trial name
- NCT02195739
- Where
- United Kingdom
- Volunteers
- 61,050 people, healthy volunteers welcome
- Sponsor
- Research in Real-Life Ltd
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection better than a…
- Trial name
- NCT07071623
- Testing
- MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF)
- Where
- 30 sites in Kenya, South Africa and 1 more
- Volunteers
- 4,580 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Reflux, Renal Excretion
Renal Impairment Study
The purpose of this study is to see how quickly AZD3355 is taken up in to the blood and leaves the blood in people with normal kidney function or with different degrees of reduced kidney function.
- Trial name
- NCT00863161
- Testing
- AZD3355
- Where
- 3 sites in Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Human Immunodeficiency Virus (HIV)
Phase II Safety and Acceptability of an Investigational Injectable Product, TMC278LA, for Pre-Exposure Prophylaxis
This is a multi-site, double-blinded, two-arm, two:one, randomized, trial comparing the safety of an intramuscular (IM) injection of TMC278 LA to a placebo given once every eight weeks over a 40 week period among sexually active…
- Trial name
- TMC278LA (NCT02165202)
- Testing
- Rilpivirine
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- PATH
Depression
Positive Affect Treatment for Adolescents With Early Life Adversity
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today.
- Trial name
- PAT4ELA (NCT06273137)
- Testing
- Positive affect treatment, Supportive psychotherapy (SUP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Body Temperature Changes, Heat Stress
Progressive Heat Exposure and Physiological Strain
Occupational heat-stress guidelines are commonly based on the level of environmental heat exposure and are largely derived from studies conducted under constant environmental conditions.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07847437
- Testing
- Constant Heat Exposure, Progressively Increasing Heat Exposure
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Hypertension
L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia
Cardiovascular disease (CVD) continues to be the major cause of morbidity and mortality in western countries. It has been shown that CVD events are known to be higher in the winter than in the summer.
- Trial name
- NCT02104375
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
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