Clinical trials: Exposure
Atopic Diseases
Markers of Atopy in Children With Presumed Early Exposure to Allergens, Unhygienic Conditions, and Infections
There are many studies regarding possible causes of increasing trend in frequency of allergic diseases in the last three decades.
- Trial name
- NCT00503048
- Where
- Poland
- Volunteers
- 915 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Chikungunya Virus Infection
Chikungunya Vaccine (V184) Study in Previously Exposed Adults (V184-006)
Safety and immunogenicity of the investigational V184 chikungunya vaccine will be tested in participants with history of chikungunya infection.
- Trial name
- NCT03807843
- Testing
- V184
- Where
- Puerto Rico
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Themis Bioscience GmbH
Verbal Abuse
Is There a Desensitization During Sleep After Exposure to a Violent Verbal Input ?
There is a need for quantify the emotional and neurophysiological perception of verbal violence, in order to understand the impact it might have on a subject.
- Trial name
- COREV (NCT03074578)
- Testing
- Watching Video-clip 1, Watching Video-clip 2
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
Noise Exposure, Surgery
Noise in the OR at Induction: Patient and Anesthesiologists Perceptions
Noise in the operating room is common and often unavoidable, but there is mixed evidence of its impact. Previous research has suggested that excessive noise at the time when a patient is being 'put to sleep' may lead to care…
- Conditions
- Noise Exposure, Surgery, Patient Satisfaction, Anesthesia
- Trial name
- NCT04204785
- Testing
- Noise Reduction Education
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
PrEP Adherence Monitoring
IN-US-276-1340: Pre-Exposure Prophylaxis to Prevent HIV Acquisition in US Women: A Demonstration Project
The overall aim of this study is to assess attitudes toward PrEP, feasibility of Truvada PrEP procurement through the established access procedures, and adherence to Truvada PrEP among US women at risk for HIV acquisition.
- Trial name
- NCT03058835
- Testing
- tenofovir disoproxil and emtricitabine
- Where
- 4 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
HIV
Implementation and Deliver of Lenacapavir for PrEP in a Community Pharmacy Setting
This is an open-label, single center study to evaluate implementation of a pharmacist-managed delivery of L4P in a community pharmacy setting and the impact of twice-yearly vs. quarterly PrEP visits on STI rates.
- Trial name
- L4PinPharm (NCT07210125)
- Testing
- Lenacapavir long-acting, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kelley-Ross & Associates, Inc.
Healthy Volunteers, Aging, Healthy
Intervention Program for Psychological Well-Being in Institutionalized Older Adults Through Virtual Reality
This randomized controlled trial (N = 60) evaluates the acceptability and efficacy of an immersive virtual reality (IVR) intervention designed to enhance psychological well-being in older adults without cognitive impairment…
- Trial name
- RRCE (NCT07884435)
- Testing
- Active IVR Group, Passive IVR Goup
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Francisco Antonio Nieto Escámez
Work-related Illness
Effect of Phosphate Exposure on Workers Health
To minimize negative health effects on health of workers in phosphate mining, it is important to assess, and diagnose health related effect of phosphate exposure \& health hazards related to miners.
- Trial name
- NCT05094076
- Testing
- chest x ray
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anxiety Disorders
Test of an Inhibitory Learning Model of Extinction in Treatment of Anxious Youth
Recently, basic research conducted in adults has revealed that fear extinction, or the weakening of a learned fear response, may be best explained by principles of "inhibitory learning." New guidelines for the clinical practice…
- Trial name
- NCT03372915
- Testing
- Standard Exposure, Exposure + Inhibitory Learning
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Patient Adherence, HIV Seronegativity
CCTG 595: Text Messaging Intervention to Improve Adherence to PrEP in High-risk MSM
CCTG 595 is a controlled, open-label, two-arm, randomized (1:1) clinical demonstration project to determine if the use of a text-message based adherence intervention (iTAB) improves retention and adherence to PrEP compared to…
- Trial name
- NCT01761643
- Testing
- SoC + iTab
- Where
- 4 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
"Exposure to Heat"
The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress.
- Trial name
- NCT00808925
- Testing
- exposure to heat
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Prof. Yoram Epstein
Tobacco Use
Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes
This study is designed to evaluate the abuse liability of mentholated very low nicotine cigarettes compared to nicotine gum and usual brand cigarettes.
- Trial name
- NCT03559725
- Testing
- VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Nicotine Exposure, Nicotine Withdrawal Suppression
The Effect of Electronic Cigarette (ECIG) Liquid Vehicles on ECIG Acute Effects
This study examines the acute effects in ECIG users of the two primary vehicles in ECIG liquids, propylene glycol and vegetable glycerin.
- Trial name
- NCT02500615
- Testing
- ECIG liquid vehicles
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Spinal Cord Injury
Body Temperature in Persons With Tetraplegia When Exposed to Heat
The deleterious effects of hyperthermia are well appreciated in able-bodied persons. However, the consequences of impaired regulation of normal body temperature on cognitive performance of persons with tetraplegia is not known.
- Trial name
- NCT01890915
- Testing
- Heat Exposure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Malaria
Impact of TMP-SMX Prophylaxis on Malaria Infection and Immunity in Children in Uganda
Background: Malaria is a disease that affects many children and adults in Uganda and Africa. If it is not treated, it can make some people severely ill.
- Trial name
- NCT02094508
- Where
- Uganda
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anxiety Disorders
Medication Enhanced Rapid Therapy
The purpose of this research study is to determine whether taking a one-time dose of a combination of putatively learning-enhancing medications can improve treatment response to a brief learning-based psychotherapy for public…
- Trial name
- MERiT (NCT02099825)
- Testing
- d-cycloserine and mifepristone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Influenza
Prospective Study of AI H5N1 in China
The purpose of this study is to see if people in China who have contact with someone infected with bird flu (H5N1) become infected themselves without necessarily getting sick.
- Trial name
- NCT00428493
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Occupational Exposure
Sevoflurane Human Biomonitoring in Operating Room Personnel
Sevoflurane is a widely used volatile agent for induction and maintenance of anaesthesia. The administration of sevoflurane involves the risk of occupational exposure.
- Trial name
- NCT03891316
- Testing
- HFIP and Sevoflurane are measured after 3 consecutive days of work.
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Colitis, Ulcerative, Crohn's Disease
OTIS Vedolizumab Pregnancy Exposure Registry
The purpose of this study is to assess the prevalence of major structural birth defects in infants of female participants with ulcerative colitis (UC) or Crohn's disease (CD) exposed to vedolizumab during pregnancy, compared to…
- Trial name
- NCT02678052
- Testing
- Vedolizumab, Other Biological Agent
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy
Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites
This is an open label, single sequence, crossover study. In Part 1, eligible subjects will participate in 3 treatment periods, in which they will receive the following treatments in turn: 1) In Period 1, a single 350-mg dose of…
- Trial name
- NCT03512548
- Testing
- Relacorilant 350mg, Itraconazole, Relacorilant 300mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
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