Clinical trials: Exposure
Healthy
Interaction Between Paracetamol and Lamotrigine: A Clinical Interaction Study
The investigators will study the effect of paracetamol on the steady state metabolism of lamotrigine in 12 healthy male volunteers. Subjects will receive lamotrigine, slowly titrated from 25 mg daily to 100 mg daily over 28 days.
- Trial name
- NCT02303106
- Testing
- Lamotrigine
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Per Damkier
Coronavirus Infections
Comparative Study of Hydroxychloroquine and Ivermectin in COVID-19 Prophylaxis
We have to be aware of the challenge and concerns brought by 2019-nCoV to our healthcare workers. Front-line healthcare workers can become infected in the management of patients with COVID-19; the high viral load in the…
- Trial name
- NCT04384458
- Testing
- Hydroxychloroquine, Ivermectin
- Where
- Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Sleep Disorders in Children, Environmental Exposure
Environmental Assessment of Sleep in Youth
In this research study, investigators want to learn more about the factors that influence children's breathing during sleep and their sleep quality.
- Trial name
- EASY (NCT03224455)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Anthrax
VELOCITY: An Anthrax Vaccine Clinical Study
This study is designed to evaluate the lot consistency (using three consecutively manufactured lots), safety, and ability of the AV7909 anthrax vaccine to generate an immune response in healthy adults and compare the response to…
- Trial name
- NCT03877926
- Testing
- AV7909, BioThrax
- Where
- 35 sites in United States
- Volunteers
- 3,689 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Persian Gulf Syndrome, Occupational Exposure
Investigate Olfactory Functioning as a Possible Proxy for Neurotoxic Exposure in Cohorts of Deployed and Non-Deployed Gulf War-Era Veterans.
Significant subsets of military veterans have reported such health problems as headache, joint pain, fatigue, and memory/concentration difficulties subsequent to their participation in the Gulf War.
- Trial name
- NCT00007514
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Pregnancy Related, Anxiety in Pregnancy
The Effect of Exposure to an Informative Video About Amniocentesis Before the Procedure on Maternal Anxiety
The effect of exposure to an informative video about amniocentesis before the procedure on maternal anxiety
- Conditions
- Pregnancy Related, Anxiety in Pregnancy, Amniocentesis Affecting Fetus or Newborn
- Trial name
- NCT05463549
- Testing
- Informative video
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Cancer, Mental Health
Healthspan Connect Programme of Research
Healthspan Connect is a new research programme designed to understand what helps people stay healthy as they age. The programme will explore how lifestyle, environment, genetics, and social factors influence healthy ageing and…
- Conditions
- Cancer, Mental Health, Ageing Well, Resilience
- Trial name
- NCT07209774
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Infections, Streptococcal
Primary and Booster Vaccination Study With a Pneumococcal Vaccine in HIV Infected, HIV Exposed Uninfected and HIV Uninfected Children 6 to 10 Weeks of Age.
The purposes of this study: To evaluate the immunogenicity, safety and reactogenicity of pneumococcal vaccine GSK1024850A in HIV infected infants, HIV exposed uninfected infants and HIV unexposed uninfected infants following a…
- Trial name
- NCT00829010
- Testing
- Pneumococcal vaccine GSK1024850A, Tritanrix-HepB/Hib, measles
- Where
- South Africa
- Volunteers
- 489 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV, Insulin Sensitivity
Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, Botswana
The purpose of this study is to assess the early longitudinal metabolic effects including insulin sensitivity in HIV-exposed uninfected (HEU) children compared to HIV-unexposed uninfected (HUU) children; as well as to determine…
- Conditions
- HIV, Insulin Sensitivity, Diabetes Mellitus
- Trial name
- NCT03088410
- Testing
- Zidovudine, Nevirapine
- Where
- Botswana
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Chronic Obstructive Pulmonary Disease
Pharmacokinetic Study to Compare Itepekimab Exposure When Administered With an Autoinjector Versus Prefilled Syringe
This Phase 1, single-center study will be conducted in an open-label, randomized, parallel design. Healthy male and female participants aged 18 to 65 years will receive a single dose of itepekimab subcutaneous (SC) administered…
- Trial name
- NCT06114238
- Testing
- Itepekimab AI, Itepekimab PFS
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sanofi
Tularemia
Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine
This study is designed to determine the safety and immunogenicity of a Live Francisella tularensis Vaccine
- Trial name
- NCT00787826
- Testing
- Live Francisella Tularensis Vaccine
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Infant, Low Birth Weight, Infant, Premature, Diseases
Farm Work & Preterm Low Birthweight Among Hispanic Women
The most persistent and intractable cause of infant and child mortality and morbidity in the US remains preterm and low birthweight deliveries.
- Trial name
- NCT00015613
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Healthy
Efficacy of Respiratory Protection Against the Effects of Wood Smoke Exposure in Young Healthy Adults
Purpose: This study is designed to test whether the gaseous fraction of woodsmoke, volatile organic compounds, produce acute cardiac, respiratory, and systemic inflammatory health effects after controlled exposure to woodsmoke in…
- Trial name
- MASKON (NCT06066749)
- Testing
- Filtration of all PM and VOC's, Filtration of VOC's
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Subjects
Methemoglobin Concentration in High Dose Inhaled Nitric Oxide
The goal of this clinical trial is to learn about the kinetic of methemoglobin in healthy subjects breathing high dose inhaled nitric oxide.
- Trial name
- NCT05612074
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognition
The Study on Effects of Acute Exposure to High Altitude Hypoxia on Cognitive Function in Lowlanders
The purpose of this study is to investigate the impact of rapid elevation to 3,800 meters on the cognitive function of low-altitude residents through a plateau field and plain control study, and explore the objective indicators…
- Trial name
- NCT05411185
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Post SARS-CoV2 (COVID-19)
Home-Based Exercise Tele-Rehabilitation After COVID-19
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in catastrophic infections and fatalities across the nation. Many older Veterans with comorbidities are especially vulnerable to complications and poor recovery.
- Trial name
- BOOST (NCT05425264)
- Testing
- Tele-exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Rabies
Randomized Phase II Trial on Safety and Neutralizing Activity of CL184 and Rabies Vaccine Versus Human Rabies Immune Globulin (HRIG) and Rabies Vaccine in Children and Adolescents
The aim of this study is to evaluate the safety of the monoclonal antibody cocktail CL184 in combination with rabies vaccine compared with human rabies immune globulin (HRIG) in combination with rabies vaccine in healthy children…
- Trial name
- NCT00708084
- Testing
- CL184, HRIG
- Where
- Philippines
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Seasonal Allergic Rhinitis (SAR)
A Study to Determine the Optimal Dose and Frequency of ALDP001 Nasal Spray in Adults With Seasonal Allergic Rhinitis Under Allergen Exposure
This study aims to evaluate the effectiveness and safety of ALDP001 Nasal Spray in treating seasonal allergic rhinitis, and to identify the optimal dosage and administration frequency for this formulation.
- Trial name
- ALDP001 (NCT07219849)
- Testing
- ALDP001 Nasal Spray
- Where
- Canada
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Alixer Nexgen Therapeutics Limited
Chronic Obstructive Pulmonary Disease, Healthy
Biosensor and Environmental Sensor Development Within the REMEDIA Project
The aim of this proof-of-concept study is to obtain data that will contribute to the development of sensor devices (biosensor and environmental sensor) for patients with lung diseases (e.g. COPD).
- Trial name
- NCT06035276
- Testing
- Exposure to clean air, Exposure to urban air
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
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